Early screening of children with Autism Spectrum Disorder (ASD) needs to be improved to propose early interventions. Parental questionnaires are useful to help primary care professionals and nurseries to detect children’s autism signs. Our primary objective is to estimate the positive predictive value of an early detection kit composed of 2 parental questionnaires M-CHAT-R/F™ (Modified-CHecklist for Autism in Toddlers-Revised/Follow-up) and CSBS DP™-ITC (Communication and Symbolic Behavior Scales Developmental Profile-Infant Toddler Checklist) followed by a psychologist’s confirmation. Methods and Analysis: Boys and girls aged 16 to 30 months, seen at their general or paediatric practice or attending nurseries or early childcare centers, never diagnosed ASD, are eligible. We plan to have a cohort of 1700 children filling the screening kit and expect to detect about 81 children confirmed positive . We also expect to detect other neurodevelopmental disorders than ASD. Discussion: The use of 2 questionnaires and the intervention of trained psychologists should optimize the access to early detection of ASD near home and links between childhood professionals. Our study is coherent with the French organization and existing tools.
