Maha Saad Elmenshawi

General Organization For Teaching Hospitals and Institutes

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Gena M. Elmakromy

Badr University in Cairo

Mahitab M. Nageeb

Zagazig University

Sabah Mohamed Hanafy

Zagazig University

Marwa AbdEl-Moniem Amer

Zagazig University

Dena Abdel Moawed

Zagazig University

Dena Mohamed Naguib Abdel Moawed

Badr University in Cairo

Marwa Amer

Alfaisal University

Doaa Hendawy

Zagazig University

Doaa M. Hendawy

Zagazig University

Cooperative Institutions

Zagazig University

Badr University in Cairo

Alfaisal University

King Faisal Specialist Hospital & Research Centre

Weatherford College

University of Alabama at Birmingham

Society of Critical Care Medicine

St. John Fisher College

Al Baha University

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The alleviative efficacy of sildenafil and chrysin against zinc oxide nanoparticles-provoked hepatic and blood toxicity: role of MyD88/NF-κB1/TNF-α pathway

Beni-Suef University Journal of Basic and Applied Sciences (2023)

Mahitab M. Nageeb Marwa AbdEl-Moniem Amer Doaa M. Hendawy Sabah Mohamed Hanafy Maha Saad Elmenshawi

Abstract Background Zinc oxide nanoparticles are nanoparticles of metal oxide with semiconductor properties and proved many noxious effects on the mammalian cell. Sildenafil, a phosphodiesterase inhibitor, and chrysin, one of the flavonoids, proved to have anti-inflammatory and anti-oxidative stress effects. Methods 48 rats were grouped into 8 groups equally. 1. (Control group) received normal diet and NaOH was added to water, 2. (chrysin group): 250 mg/kg, orally for 10 days, 3. (sildenafil group): 40 mg/kg, orally for 14 days, 4. (ZnO-NPs group): 200 mg/kg, intraperitoneal for 10 days, 5. (ZnO-NPs + chrysin as a prophylactic agent): given in the same previous doses and durations consecutively, 6. (ZnO-NPs + chrysin as a curative agent): given in the same previous doses and durations with chrysin given after ZnO-NPs administration for 10 days, 7. (ZnO-NPs + sildenafil as a curative agent): given in the same previous doses and durations with sildenafil given after ZnO-NPs administration for 10 days, and 8. (Combined treatment group chrysin + sildenafil) as combined treatment were given in the same previous doses and durations after ZnO-NPs administration for 10 days. Blood and samples from tissues were withdrawn for histopathological, biochemical studies, and comet assay at the end of the experiment. Results Sildenafil and chrysin proved to protect from hepatotoxicity and hematotoxicity induced by zinc oxide nanoparticles as they lessened aspartate transaminase, alanine transferase, and alkaline phosphatase levels. They also reduced the oxidative stress enzyme levels. Gene expression of myeloid differentiation factor 88, nuclear factor kappa B1, tumor necrosis factor, and DNA damage decreased with treatment. Also, there was an improvement in the histopathological picture of the liver seen with treatment. Concurrent administration of sildenafil and chrysin revealed much better improvement than either drug used alone. Conclusion Chrysin and sildenafil have ameliorative effects against ZnO-NPs-induced hepatotoxicity and hematotoxicity, their protective effect is either preventive with chrysin or curative with chrysin and sildenafil.

Chrysin

10.1186/s43088-023-00440-2

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Regression of Paracetamol provoked hepatotoxicity and nephrotoxicity by Spirulina, Butylated hydroxytoluene and Cilostazol in adult male albino rats: Modulation of inflammatory, oxidative stress and apoptotic biomarkers

Egyptian Society of Clinical Toxicology Journal (2023)

Marwa Amer Mahitab M. Nageeb Sabah Mohamed Hanafy Doaa Hendawy Maha Saad Elmenshawi

Background: Paracetamol (acetaminophen) is one of the over-the-counter analgesic antipyretic drugs.It is associated with hepatotoxicity and nephrotoxicity in overdose.Spirulina, and Butylated hydroxytoluene are valuable antioxidants.Cilostazol is a phosphodiesterase type 3 inhibitor with protective effects in some hepatic and renal injury models.Aim of the work: This study aims to evaluate the ameliorative effect of spirulina, BHT, and cilostazol against paracetamol-induced hepatotoxicity and nephrotoxicity.Material and Methods: fifty-four adult male Wistar rats were classified into 9 equal groups: I (Control group), II (Paracetamol group), III (Spirulina group), IV (BHT group), V (Cilostazol group), VI (Paracetamol+Spirulina preventive group), VII (Paracetamol+BHT preventive group), VIII (Paracetamol+Spirulina+BHT preventive group) and IX (Paracetamol+Cilostazol treatment group).Blood samples were collected at the end of the study and rats were then sacrificed and livers and kidneys were handled for biochemical, histopathological, and immunohistochemical studies.Results: Paracetamol overdose persuaded a significant elevation in serum liver enzymes (AST, ALT and ALP), urea, and creatinine levels.Also, it induced a significant elevation in serum MDA with a substantial decrease of hepatic GST, SOD in the liver, and catalase in the kidney.It also increased the expression of MAPK, JNK, IL8, NF-κB1, BAX and immunohistochemical P53.The administration of spirulina, BHT, and cilostazol with paracetamol significantly improves these previous parameters, implying that hepatic and renal tissues were sheltered from paracetamol"s hazardous effects.Conclusion: Spirulina, BHT and Cilostazol administration ameliorated Paracetamol hepatotoxicity and nephrotoxicity through antioxidant, antiinflammatory, and anti-apoptotic impacts.

Butylated hydroxytoluene

Cilostazol

Nephrotoxicity

Spirulina (dietary supplement)

Acetaminophen

10.21608/esctj.2023.252160.1045

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