Kilambi Pundarikakshudu

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"Cytotoxic Activity of Some Water Soluble Curcumin Conjugates on Human Colorectal Adenocarcinoma and Human Hepatocellular Carcinoma Cells"

Biomedical Journal of Scientific & Technical Research (2023)

Kilambi Pundarikakshudu

Curcumin has been reported to be an effective and safe molecule for the treatment of a number of cancers. But its utility was restricted due to its poor water solubility and poor bio-availability due to degradation.

10.26717/bjstr.2023.50.007990

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Citations (0)

Comparative study between simple and optimized liposomal dispersion of quetiapine fumarate for diffusion through nasal route

Drug Delivery (2015)

Pratik Upadhyay Jatin Trivedi Kilambi Pundarikakshudu Navin Sheth

Nasal route of drug administration is preferred more and more for the targeted delivery to the brain in current drug development scenario due to its ease of use, reliability, quick action, and lesser side effects. Those CNS drugs which have limited oral bioavailability due to pharmacokinetic consequences and brain barrier repulsion are getting onto this direction.Quetiapine fumarate, an analogous to above and an antischizophrenic agent, is tested for its diffusion property with and without lipophilic carrier through sheep nasal membrane. Being a BCS class II' and high permeable candidate, it tends to crossover easily, so made up in a simple dispersion.To improve its diffusion rate, it was embedded into liposomal dispersion, which has proven that it has advanced efficiency for diffusion. For this, both the formulations were checked and compared for their diffusion profile, as it is an essential property for bioavailability through nasal route. Comparison was made on the basis of % drug diffusion within 6 h, rate, mechanism, profile, and coefficient.Liposomal dispersion has been proved superior with greater percentage diffusion of 32.61 ± 1.70 and very high permeability with a coefficient value of 4.1334 ± 0.7321 (× 10 (-) (5 )cm/s). Diffusion profile comparison bearing dissimilarity of 18 and similarity of 74 indicated that the diffusion profiles of liposomal dispersions and simple dispersion were similar but not identical.Liposomal diffusion supremacy was further sustained by in vivo, ciliotoxicity, and gamma scintigraphy studies.

Quetiapine Fumarate

10.3109/10717544.2015.1120364

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Citations (21)

Simultaneous quantitation of piperine and piperlongumine in the fruit ofPiper longumLinn. by validated high-performance thin-layer chromatography-densitometric method

JPC - Journal of Planar Chromatography - Modern TLC (2014)

Kilambi Pundarikakshudu Anilkumar Sharma Chaitanya Bhatt Niranjan Kanaki

Piperine

Densitometry

10.1556/jpc.27.2014.5.6

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Citations (4)

Antidiabetic and antihyperlipidemic activity of Euphorbia thymifolia L. extracts on streptozotocin-nicotinamide induced type 2 diabetic rats

Journal of Applied Pharmaceutical Science (2017)

Ghanshyam Parmar Kilambi Pundarikakshudu R Balaraman

Effect of Nigella sativa supplementation on human lipids: systematic reviewRedhwan Ahmed Al-Naggar, Muhamed T. Osman, Isa Naina Mohamed, Khairun Nain Bin Nor Aripin, Mahfoudh A. M. Abdulghani

Nigella sativa

10.7324/japs.2017.70811

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Citations (12)

Fenugreek: A Wonder Spice with Versatile Pharmacological Activities and Clinical Applications

Springer eBooks (2021)

Kilambi Pundarikakshudu Priya Shah

Spice

Wonder

10.1007/978-981-16-1197-1_18

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Citations (3)

Novel TLC Densitometric Method for Quantification Of Solasodine in Various Solanum Species, Market Samples and Formulations

Chromatographia (2006)

Piyush Trivedi Kilambi Pundarikakshudu

Solasodine

10.1365/s10337-006-0136-z

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Citations (28)

Direct and enhanced delivery of nanoliposomes of anti schizophrenic agent to the brain through nasal route

Saudi Pharmaceutical Journal (2016)

Pratik Upadhyay Jatin Trivedi Kilambi Pundarikakshudu Navin Sheth

The problem of inadequate oral bioavailability of Quetiapine Fumarate, a lipophilic drug used for schizophrenia, due to hepatic metabolism and repulsion by brain barrier was attempted in this study. Combination of two approaches, viz. Quetiapine inclusion into the liposomal carrier for better diffusion and administration through nasal route to avoid hepatic metabolism and barrier elimination was applied. Thin film hydration followed by sonication method was employed in liposome preparation and the formulation was optimized using 32 full factorial design. The number of sonication cycles (X1) of 2 min and 80% amplitude and molar ratio of constructional components such as cholesterol to egg phosphatidylcholine (X2) as independent variables and a % of entrapment efficiency (Y1) and cumulative in vitro drug release (Y2) at 6 h as dependent variables was selected. Batch F7 prepared by 2 cycles of sonication and 1:3 M ratio of cholesterol:egg phosphatidylcholine was optimized as a consequence of substantial entrapment efficiency of 75.63 ± 3.77%, and 99.92 ± 1.88% drug release and 32.33 ± 1.53% drug diffusion, which was optimum among all other batches at 6 h. Diffusion study was done for all the batches of liposomal formulation by using sheep nasal mucosa and good amount with better diffusion rate was measured which proved liposomal dispersion a virtuous delivery system for brain drug delivery through nasal route. Results of in vivo, ciliotoxicity and gamma scintigraphy studies on mice supported the above inference.

Sonication

10.1016/j.jsps.2016.07.003

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Citations (40)

High-performance thin-layer chromatographic method for the simultaneous quantification of piperine, piperlongumine, and 6-shogaol in Trikatu Churna — an Ayurvedic formulation

JPC - Journal of Planar Chromatography - Modern TLC (2017)

Anilkumar Sharma Chaitanya Bhatt Kilambi Pundarikakshudu

Piperine

10.1556/1006.2017.30.1.6

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Citations (3)

Effect of ethanol extract of an ayurvedic preparation (Pathyadya Churna) on arthritis in rats

Indian Journal of Pharmacology (2016)

Kilambi Pundarikakshudu MadhaviG Patel

Objectives: To study the anti-arthritic activity of Pathyadya Churna ethanol extract (PCE) in rats.
Materials and Methods: Formaldehyde (2% v/v) or complete Freund's adjuvant (CFA 0.l mL) was injected in the left hind paw of male Wistar rats to develop arthritis. These rats were treated with three doses (135, 270, and 540 mg/kg) of PCE and one dose (10 mg/kg) of indomethacin. Anti-arthritic activity of the extract was assessed by noting paw volumes, rheumatoid factor (RF), blood parameters, and histological changes.
Results: PCE treatment reduced paw swelling in arthritis caused by both formaldehyde and CFA. In CFA-treated rats, a significant decrease (P < 0.001) was seen in hemoglobin (13.92 g/dL to 9.97 g/dL), red blood cell count (7.32 million/mm³ to 6.58 million/mm³), and packed cell volume (44.04% to 30.56%). There were also significant (P < 0.001) elevations in white blood cell count (8220/–11,420/mm³), platelets (2.46–4.15 lakhs/mL), erythrocyte sedimentation rate (3.76–8.03/60 min), RF (7.17–26.77 IU/mL), triglycerides (71.69–96.60 mg/dL), total cholesterol (96.85–145.05 mg/dL), low-density lipoprotein (53.11–109.60 mg/dL), and very low-density lipoprotein (14.34–19.32 mg/dL). In CFA-induced arthritic rats, high-density lipoprotein decreased significantly (29.40 mg/dL to 16.13 mg/dL). Marked changes were noted in the histology of ankles. Treatment with PCE significantly reversed all these hematological and histological changes in a dose-dependent manner.
Conclusions: PCE has a significant anti-arthritic activity in rats and is free from toxic effects.

Erythrocyte sedimentation rate

Low-density lipoprotein

High-density lipoprotein

10.4103/0253-7613.178828

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Citations (3)

Beneficial effect of aspirin against interferon‐α‐2b—induced depressive behavior in Sprague Dawley rats

Clinical and Experimental Pharmacology and Physiology (2016)

Shailendra Bhatt Kilambi Pundarikakshudu Paresh K. Patel Nirav Patel Ashish R. Panchal

Accumulating data advocates that inflammatory mediators may contribute to depression in experimental models as well as in humans. Nonetheless, whether anti-inflammatory treatments can prevent depression still remains controversial. To substantiate our hypothesis, we used an interferon-α-2b model of depression using Sprague Dawley rats. Interferon-α-2b is a cytokine which activates immune response and also produces depression. The animals were treated for 21 days with aspirin (10 mg/kg, per oral (p.o.)) dexamethasone (1 mg/kg p.o.) and amitriptyline (10 mg/kg p.o.). Amitriptyline was used as reference standard, and given concurrently with aspirin and dexamethasone to examine any synergy. Interferon-α-2b (6000 IU/kg, intraperitoneal (i.p.)) was administered in all the above groups daily, except normal control. Tests performed included sucrose preference test, behavioural tests like forced swim test, elevated plus maze, light dark box and locomotor activity along with biochemical estimations like serum cortisol and brain neurotransmitters. The rats in the group treated with Interferon-α-2b produced depressive behaviour in rats. We found that animals treated with aspirin decreased immobility time in forced swim test, increased sucrose preference, decreased serum cortisol and increased brain serotonin levels signifying antidepressant action. In contrast, there was no effect in groups treated with dexamethasone. Our results suggest that aspirin can serve as a potential antidepressant both individually and as adjuvant agent in the treatment of depression. Inhibition of the cyclo-oxygenase-2 levels and prostaglandins concentration or any other potential physiological and biochemical mechanisms may be involved in antidepressant effect.

10.1111/1440-1681.12660

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Citations (9)