Haruo Miyagawa

Takenaka (Japan)

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Citation

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Research Field

Role of lipid peroxidation and free radical scavengers on endotoxin shock

Bioelectrochemistry and Bioenergetics (1987)

Toshikazu Yoshikawa Toshiki Takemura Tohoru Tanigawa Haruo Miyagawa Norimasa Yoshida

10.1016/0302-4598(87)85031-6

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Citations (4)

DAMAGE TO BUILDING FOUNDATION DURING THE 1995 HYOGOKEN-NANBU EARTHQUAKE

AIJ Journal of Technology and Design (1997)

Masao MARUOKA Masamichi AOKI Eiji Sato Yoshio Hirai Haruo Miyagawa

On the basis of the investigation results of building foundations and restoration of the damaged buildings during the 1995 Hyogoken-Nanbu earthquake, the classification of damage level is proposed, and the relationship between the damage level and inclination, settlement, restration of damaged buildings are shown.

Foundation (evidence)

Settlement (finance)

Types of earthquake

10.3130/aijt.3.85_2

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Citations (2)

Increase in Lipid Peroxidation in Rat Gastric Mucosal Lesions Induced by Water-Immersion Restraint Stress

Journal of Clinical Biochemistry and Nutrition (1986)

Toshikazu Yoshikawa Haruo Miyagawa Norimasa Yoshida Shigeru Sugino Motoharu Kondo

The role of lipid peroxidation in the pathogenesis of gastric ulcer was investigated in a rat model produced by water-immersion restraint stress. After the immersion of rats in 23°C water with restraint, blood flow of the gastric wall was significantly decreased and hemorrhagic erosions were seen in the body of the stomach. Thiobarbituric acid-reactive substances, an index of lipid peroxidation, in the gastric mucosa were significantly increased after the stress. These results suggest that lipid peroxidation may play a role in the pathogenesis of gastric mucosal lesions induced by stress.

Thiobarbituric acid

Pathogenesis

Ulcer index

Stress ulcer

10.3164/jcbn.1.271

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Citations (63)

A CASE OF INTESTINAL METAPLASIA OF THE STOMACH SHOWING MARKED EXTENT FOR 8 YEARS

Acta gastro-enterologica belgica (1984)

Junichi Okuda Haruo Miyagawa Masayuki Ozaki Keishi Takechi Shuji Kato

Intestinal metaplasia

10.11280/gee1973b.26.1538

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Citations (1)

[Protective effects of a protease inhibitor, urinastatin, on endotoxin shock and its scavenging effect on oxygen-derived free radicals].

PubMed (1988)

Takaki Yoshikawa Morio Murakami O Seto N Yoshida T Takemura

Scavenging

Source

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Citations (4)

E6010 subacute toxicity study in rats on repeated intravenous administration for 4 weeks followed by a 2-week recovery period

Yakuri to chiryō (1994)

S. Sumigama Akihiro Shirakabe Haruo Miyagawa T. Aoki Naruo Katsutani

Source

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Citations (1)

[Role of free radicals in the formation of stress ulcer in rats].

PubMed (1987)

Haruo Miyagawa

Stress ulcer

Source

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Citations (0)

Role of Free Radical Lipid Peroxidation in Burn and Endotoxin Shock

Springer eBooks (1987)

Takeo Yoshikawa N. Yoshida Haruo Miyagawa T Takemura Tohru Tanigawa

Allopurinol

10.1007/978-1-4613-0919-2_9

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Citations (2)

Determination of superoxide generated by human polymorphonuclear leukocytes by ESR and its clinical application.

Ensho (1988)

Toru Tanigawa Toshikazu Yoshikawa Haruo Miyagawa Shigenobu Ueda Toshiki Takemura

Electron spin resonance (ESR) is regarded as the least ambiguous method for the detection of free radicals. Using spin trapping technique with 5, 5-dimethyl-pyrroline-N-oxide (DMPO) we measured superoxide generated by stimulated polymorphonulcear leukocytes (PMN) . The results were compared to those by chemiluminescence study with Cypridina luciferin analog (CLA) which is highly sensetive to superoxide. ESR spectrum was obtained by JEOL-JES-FE2XG ESR spectrometer. The intensity of the signal of DMPO-OOH adduct was measured as ratio to the intensity of Mn2+ signal. Phorbol myristate acetate or opsonized zymosan were used as stimulants of PMN. The ESR signal of DMPO-OOH was completely inhibited by superoxide dismutase, but not affected by catalase or sodium azide. The relative intensity of DMPO-OOH signal and the maximal increase of CLA-dependent chemiluminescence were increased in proportion to the xanthine oxidase unit in hypoxanthine +xanthine oxidase system, and to the cell concentration in PMN system. There were positive correlation between the relative intensity of the ESR signal of DMPO-OOH and CLA-dependent chemiluminescence by stimulatd PMN from patients. By ESR assay, increased generation of superoxide by PMN in patients with fairly controlled diabetes was shown.

Sodium azide

Zymosan

10.2492/jsir1981.8.443

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Citations (2)

Role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced by water-immersion restraint stress and burn stress in rats.

Journal of Clinical Biochemistry and Nutrition (1990)

Toshikazu Yoshikawa Norimasa Yoshida Yuji Naito Toshiki Takemura Haruo Miyagawa

The formation of gastric mucosal lesions and the increase in thiobarbituric acid (TBA)-reactive substances induced by water-immersion restraint stress or burn stress in rats were significantly inhibited by the treatment with superoxide dismutase (SOD) and/or catalase. Allopurinol inhibited the formation of gastric mucosal injury induced by burn stress, but not the increase in TBA reactants. A drop in the polymorphonuclear leukocyte (PMN) count induced by an injection of anti-rat PMN antibody did not inhibit the aggravation of gastric mucosal lesions or the increase in TBA reactants in either of the stress models. These results suggest that active oxygen species and lipid peroxidation may play a role in the formation of gastric mucosal damage induced by stress. Reduced microcirculation of the gastric mucosa induced by water-immersion restraint or burn stress did not change following treatment with SOD and/or catalase, suggesting that the effectiveness of SOD and catalase on the gastric mucosal lesions induced by stress may occur via the scavenging of oxygen radicals, and not through an effect on gastric mucosal microcirculation.

Thiobarbituric acid

Stress ulcer

Pathogenesis

Mucosal lesions

10.3164/jcbn.8.227

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Citations (22)