Gemma Aragonès

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

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L. Masana

Institut d'Investigació Sanitària Pere Virgili

Mercedes Heras

Hospital Universitari Sant Joan de Reus

Josefa Girona

Institut d'Investigació Sanitària Pere Virgili

Teresa Auguet

Institut d'Investigació Sanitària Pere Virgili

Raimón Ferré

Mayo Clinic

Núria Plana

Universidad Rovira i Virgili

Carmen Aguilar

Institut d'Investigació Sanitària Pere Virgili

Cristóbal Richart

Universidad Rovira i Virgili

Jordi Merino

Novo Nordisk Foundation

Alba Berlanga

John Wiley & Sons (United States)

Cooperative Institutions

Instituto de Salud Carlos III

Centro de Investigación Biomédica en Red

Universidad Rovira i Virgili

Institut d'Investigació Sanitària Pere Virgili

Biomedical Research Networking Center on Neurodegenerative Diseases

Universitat de Barcelona

Hospital Universitari Sant Joan de Reus

Fundació ACE

Universitat Autònoma de Barcelona

Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas

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Journal of Vascular Research (2012)

Yanna Dantas Rattmann Eric Anselm Jong‐Hun Kim S. Dal-Ros Cyril Auger

10.1159/000341325

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Conference Calendar

Journal of Vascular Research (2012)

Yanna Dantas Rattmann Eric Anselm Jong-Hun Kim S. Dal-Ros Cyril Auger

10.1159/000339548

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Low-carbohydrate, high-protein, high-fat diet alters small peripheral artery reactivity in metabolic syndrome patients

Clínica e Investigación en Arteriosclerosis (2013)

Jordi Merino Richard Kones Raimón Ferré Núria Plana Josefa Girona

Quartile

10.1016/j.arteri.2013.11.004

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Citations (9)

Increased Circulating Levels of Alpha-Ketoglutarate in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease

PLoS ONE (2016)

Gemma Aragonès Teresa Auguet Alba Berlanga Esther Guiu‐Jurado S. Martínez

Background Non-alcoholic fatty liver disease (NAFLD) causes a wide spectrum of liver damage, ranging from simple steatosis to cirrhosis. However, simple steatosis (SS) and steatohepatitis (NASH) cannot yet be distinguished by clinical or laboratory features. The aim of this study was to assess the relationship between alpha-ketoglutarate and the degrees of NAFLD in morbidly obese patients. Materials and Methods We used a gas chromatography-quadruple time-of-flight-mass spectrometry analysis to quantify alpha-ketoglutarate in serum from normal-weight subjects (n = 30) and morbidly obese women (n = 97) with or without NAFLD. Results We found that serum levels of alpha-ketoglutarate were significantly higher in morbidly obese women than in normal-weight women. We showed that circulating levels of alpha-ketoglutarate were lower in lean controls and morbidly obese patients without NAFLD. We also found that alpha-ketoglutarate serum levels were higher in both SS and NASH than in normal liver of morbidly obese patients. However, there was no difference between SS and NASH. Moreover, we observed that circulating levels of alpha-ketoglutarate were associated with glucose metabolism parameters, lipid profile, hepatic enzymes and steatosis degree. In addition, diagnostic performance of alpha-ketoglutarate has been analyzed in NAFLD patients. The AUROC curves from patients with liver steatosis exhibited an acceptable clinical utility. Finally, we showed that the combination of biomarkers (AST, ALT and alpha-ketoglutarate) had the highest accuracy in diagnosing liver steatosis. Conclusion These findings suggest that alpha-ketoglutarate can determine the presence of non-alcoholic fatty liver in morbidly obese patients but it is not valid a biomarker for NASH.

Alpha ketoglutarate

Morbidly obese

Alpha (finance)

10.1371/journal.pone.0154601

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Hepcidin in morbidly obese women with non-alcoholic fatty liver disease

PLoS ONE (2017)

Teresa Auguet Gemma Aragonès Alba Berlanga S. Martínez Fàtima Sabench

Background Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries. Both iron and lipid metabolism seem to be involved in its pathogenesis. We aimed to assess the relationship between levels of hepcidin, the master iron-regulatory protein, in plasma and the presence of NAFLD in morbidly obese (MO) patients, and to investigate the association between the hepatic expression of the main iron and lipid metabolism -related genes. Materials and methods Enzyme-linked immunosorbent assay was used to measure plasma hepcidin levels in 49 normal-weight control women, 23 MO women with normal liver (NL) histology and 46 MO women with NAFLD. The mRNA expression of hepcidin, the main iron metabolism-related genes, and the main lipid-metabolism genes was quantified by qRT-PCR in liver biopsies from members of the MO group undergoing bariatric surgery. Results Circulating hepcidin levels were significantly greater in MO than in normal-weight control women. However, there were no significant differences between MO women with NL and those with NAFLD. PCR analysis showed increased expression of hepcidin, FPN1, TfR1 and TfR2 in the liver of MO NAFLD women compared to those with NL. Moreover, a positive association of hepatic hepcidin mRNA expression and the iron metabolism-related genes was found with some key genes involved in the lipid metabolism. Conclusion These findings suggest that circulating hepcidin levels are associated with obesity but not with the presence of NAFLD. However, the hepatic expression of hepcidin and the iron metabolism-related genes seem to play a role in regulating lipid metabolism pathways in liver, which has implications for NAFLD pathogenesis.

10.1371/journal.pone.0187065

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Citations (27)

The sequence of prenatal growth restraint and post‐natal catch‐up growth leads to a thicker intima‐media and more pre‐peritoneal and hepatic fat by age 3–6 years

Pediatric Obesity (2015)

Giorgia Sebastiani Marta Díaz Judit Bassols Gemma Aragonès Abel López‐Bermejo

Summary Background Infants born small‐for‐gestational‐age ( SGA ) who develop post‐natal weight catch‐up are at risk for insulin resistance, central adiposity and cardiovascular disease in later life, even in the absence of overweight. Objective In young (age 3–6 years) non‐obese SGA children, we assessed arterial health (as judged by intima‐media thickness [ IMT ]) and abdominal fat distribution (subcutaneous, visceral, preperitoneal and hepatic components by magnetic resonance imaging [ MRI ] and/or ultrasound [ US ]) besides a selection of endocrine markers. Methods Comparisons of measures in SGA ( n = 27) vs. appropriate‐for‐ GA ( AGA ) children ( n = 19) of similar height, weight and body mass index. Longitudinal outcomes (age 3–6 years) were carotid IMT ( cIMT ); fasting glucose, circulating insulin, IGF ‐ I and high‐molecular‐weight ( HMW ) adiponectin; abdominal fat partitioning by US . Cross‐sectional outcomes (age 6 years) were aortic IMT ( aIMT ) and abdominal fat partitioning by MRI . Results At 3 and 6 years, cIMT and IGF ‐ I results were higher and HMW adiponectin lower in SGA than AGA children; at 6 years, SGA subjects had also a thicker aIMT and more pre‐peritoneal and hepatic fat, and were less insulin sensitive (all P values between <0.05 and <0.0001). cIMT correlated positively with pre‐peritoneal fat, particularly at 6 years. Post‐ SGA status and weight gain in early childhood (between 3 and 6 years) were independent predictors of cIMT at 6 years, explaining 48 % of its variance. Conclusion SGA children aged 3–6 years were found to have a thicker intima‐ media and more pre‐peritoneal and hepatic fat than AGA children of comparable size.

Intima-media thickness

Intrauterine growth restriction

10.1111/ijpo.12053

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Citations (47)

RELATIONSHIP BETWEEN PARAOXONASE-1 (PON1), MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) AND SUB-CLINICAL ATHEROSCLEROSIS IN HIV-1 INFECTED PATIENTS

Atherosclerosis Supplements (2008)

Sandra Parra Blai Coll Judit Marsillach Gemma Aragonès Anna Rull

Paraoxonase

Monocyte

10.1016/s1567-5688(08)71050-x

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