Shan Zhou

Harbin Medical University

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Jingang Jiang

East China Normal University

Chunlai Tian

Pingxiang University

Yongde Zhang

Harbin University of Science and Technology

Weixing Duan

Guangxi Academy of Agricultural Science

Ursula A. Matulonis

Dana-Farber Cancer Institute

Jingchao Wang

Harbin Medical University

Yi-Lang Ding

First Affiliated Hospital of Fujian Medical University

Song-Xi Tang

Fujian Medical University

Hong Xiao

First Affiliated Hospital of Fujian Medical University

Hailin Huang

First Affiliated Hospital of Fujian Medical University

Cooperative Institutions

Dana-Farber Cancer Institute

Harvard University

Guangxi Academy of Agricultural Science

Ministry of Agriculture and Rural Affairs

Chinese Academy of Agricultural Sciences

Chinese Academy of Sciences

Sun Yat-sen University

Fujian Medical University

China Academy of Engineering Physics

First Affiliated Hospital of Fujian Medical University

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ICONE23-1254 FACILITY DESIGN OF THE EXPERIMENTAL TEST ON INNER STEAM CONDENSATION COUPLED OUTER EVAPORATION

The Proceedings of the International Conference on Nuclear Engineering (ICONE) (2015)

Lin Yang Cheng Li Wei Zhao Wang-Fang Du Shan Zhou

The passive containment cooling system (PCCS) is one of the important passive safety systems in the advanced pressurized water reactor (APWR), which belongs to the 3rd generation nuclear reactor. In the design basis accident, the steam condensing on the inner surface of the containment shell and the cooling water evaporating from the outer surface of the containment shell. In the process, the heat is transferred from the inside of the containment to the outside. To span the expected range of conditions and provide proper model for evaluating the inner steam condensation coupled outer evaporation heat transfer process, the inner steam condensation coupled outer evaporation experimental test (ISCOE) is developed by State Nuclear Power Technology Research & Development Centre (SNPTRD). Facility components, test section structure, supplying systems and measurement technology are described in this paper, also results of some pretests is introduced to show property of the facility.

Containment (computer programming)

Containment building

Vapor-compression evaporation

10.1299/jsmeicone.2015.23._icone23-1_128

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Allicin enhances the radiosensitivity of colorectal cancer cells via inhibition of NF‐κB signaling pathway

Journal of Food Science (2020)

Wen‐Liang Huang Shu-Fen Wu Songtao Xu Yongchao Ma Rui Wang

Abstract Radioresistance is an important factor affecting the radiotherapy effect of colorectal cancer (CRC). Allicin is a versatile sulfur‐containing organic compound extracted from garlic ( Allium sativum L.), which has many pharmacological effects. However, the effect of allicin on the sensitivity of CRC radiotherapy has not been confirmed. The present study is to observe the radiosensitivity effects of allicin and to explore its mechanism in CRC radiotherapy. The proliferation inhibition effects of allicin combined with X‐ray radiotherapy in HCT116 cells were measured by growth curve of cell and colony formation assays. The cell apoptosis was detected by Hoechst 33258 nucleus staining assay. The migration ability of cells was detected by Transwell chamber migration assay. The animal model of CRC was established in BALB/c mice via transplantation of CT26 cell, and the radiosensitization effect of allicin on CRC was detected in vivo . The mRNA expressions of NF‐κB, IKKβ, and IκBα were analyzed by reverse transcription‐polymerase chain reaction (RT‐PCR). The protein expressions of NF‐κB, p‐NF‐κB, IKKβ, p‐IKKβ, IκBα, and p‐IκBα were detected by western blotting. Our results showed that allicin improves the sensitivity of X‐ray radiotherapy in CRC, and its mechanism may be associated with inhibition of NF‐κB signaling pathway. These findings suggest that allicin may be used as a potential sensitizer for tumor radiotherapy in the clinic.

Radiosensitivity

Radioresistance

Viability assay

IκBα

MTT assay

IκB kinase

10.1111/1750-3841.15156

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Citations (26)

ICONE23-1327 A BRIEF OF THE ISCOE EXPERIMENT PLATFORM RESEARCH OBJECTIVES AND FACILITY CONSTRUCTION REQURIEMENTS

The Proceedings of the International Conference on Nuclear Engineering (ICONE) (2015)

Cheng Li Ruichang Zhao Huajian Chang Lin Yang Shan Zhou

The heat transfer from the containment inside to the atmosphere environment via the process of the wall steam condensation with non-condensable gases, the steel wall thermal conduction and the water film evaporation outside is the advanced technique for core residual heat removal during the long term depressurized stage of a nuclear power accident. Thus, the full pressure inner steam wall condensation coupled outer evaporation experimental platform has been carried out in China to take the thermal-hydraulic studies and to validate the passive safety system used in advanced PWR. The current work mainly discussed and analyzed the important wall heat transfer phenomena which were then used for the advanced PCCS design applications and safety evaluations. Necessities of the experimental studies on these evaporation and condensation phenomena were analyzed and proposed to carry out on a experimental platform. The experimental platform requirements were analyzed and then were specified for constructions. It also gave the advantages of the coupled heat and mass transfer study platform and further study objectives. Finally, the facility construction was summarized.

Thermal hydraulics

10.1299/jsmeicone.2015.23._icone23-1_151

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Positioning accuracy assessment for the 4GEO/5IGSO/2MEO constellation of COMPASS

中国科学:物理学力学天文学(英文版) (2012)

Shan Zhou

Determined to become a new member of the well-established GNSS family,COMPASS(or BeiDou-2) is developing its capabilities to provide high accuracy positioning services.Two positioning modes are investigated in this study to assess the positioning accuracy of COMPASS' 4GEO/5IGSO/2MEO constellation.Precise Point Positioning(PPP) for geodetic users and real-time positioning for common navigation users are utilized.To evaluate PPP accuracy,coordinate time series repeatability and discrepancies with GPS' precise positioning are computed.Experiments show that COMPASS PPP repeatability for the east,north and up components of a receiver within mainland China is better than 2 cm,2 cm and 5 cm,respectively.Apparent systematic offsets of several centimeters exist between COMPASS precise positioning and GPS precise positioning,indicating errors remaining in the treatments of COMPASS measurement and dynamic models and reference frame differences existing between two systems.For common positioning users,COMPASS provides both open and authorized services with rapid differential corrections and integrity information available to authorized users.Our assessment shows that in open service positioning accuracy of dual-frequency and single-frequency users is about 5 m and 6 m(RMS),respectively,which may be improved to about 3 m and 4 m(RMS) with the addition of differential corrections.Less accurate Signal In Space User Ranging Error(SIS URE) and Geometric Dilution of Precision(GDOP) contribute to the relatively inferior accuracy of COMPASS as compared to GPS.Since the deployment of the remaining 1 GEO and 2 MEO is not able to significantly improve GDOP,the performance gap could only be overcome either by the use of differential corrections or improvement of the SIS URE,or both.

Dilution of precision

Compass

Precise Point Positioning

Differential GPS

Source

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The influence of Kitchon-RCAA on biomechanics of maxillary tissues based on indirect action: A finite element analysis

Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine (2024)

Jingang Jiang Shao‐Lun Zhai Liang Yao Yongde Zhang Shan Zhou

This paper creates 3D models of Kitchon Root Controlled Auxiliary Archwire (Kitchon-RCAA) with different material properties and assembles them onto the main archwire equipped with brackets. By setting different loading methods and conducting Finite Element Analysis (FEA), the range of Orthodontic Torque/Support Force (OT/SF) values can be obtained. From the obtained values, it can be seen that changes in material properties have a significant impact on the mechanical properties of Kitchon-RCAA. When the properties of the Kitchon-RCAA material change two or more times, the mechanical values generated by Kitchon-RCAA cannot be directly added from two or more separate changes in the properties of the material. Therefore, it is necessary to simulate the model after each parameter change to obtain new results. And then the maxillary bio-model is reconstructed in reverse based on Cone Beam Computerized Tomography (CBCT) images. The biomechanical data equivalent to the mechanical mechanics generated by the root control assisted archwire is also added to the corresponding tooth positions, making indirect orthodontic behavior of Kitchon-RCAA on teeth possible. From the obtained results, it can be seen that the von Mises stress and total deformation magnitude for both normal teeth and corresponding Periodontal Ligament (PDL) position show a stable trend, while the Right Cuspid (R-C) and corresponding PDL with malformed root have a large stress concentration and may have a mold penetration problem. Overall, this paper not only analyses the mechanical behavior of the Kitchon-RCAA, this article not only analyzed the mechanical behavior of Kitchon-RCAA, but also its effect on the indirect biomechanical behavior of the teeth and PDL. And in combination with simulation result nephograms, it also enables predictability and visualization of orthodontic results. This helps dentists to provide safer and more reliable individualized orthodontic treatment plans for patients.

Periodontal fiber

Biomechanics

10.1177/09544119241305468

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Introduction of Energy Materials

Biao Kong Hongbin Xu Lei Xie Shan Zhou

With the development of science and technology, human beings are increasingly demanding energy. Various energy materials were developed for the application of energy harvest. In the following context, diverse materials that favor for the energy generation were introduced.

10.1007/978-981-99-7498-6_1

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Quality Control and Management of Research Experimental Project

Atlantis Press eBooks (2015)

Chunlai Tian Shan Zhou Liyong Han

The quality management procedure is proposed with a real case of experimental project management in this paper. The procedure includes the preparation phase, the execution phase and the conclusion phase. In each phase, the objectives which are focused on by the quality control are described. And the experimental project objectives and products are analyzed. The basic method is demonstrated with the principle of research goal oriented to improve the quality management in experimental project. It makes the quality management closely around the test objectives to found the quality control and assurance measures. The procedure applying with the method helps to contribute the smooth implementation of the experimental project. It has been applied to the recent experimental research and its efficiency has been confirmed.

10.2991/978-94-6239-148-2_85

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Targeted therapy of multiple myeloma

Exploration of Targeted Anti-tumor Therapy (2021)

Shan Zhou Renxi Wang

Multiple myeloma (MM) is a malignant proliferative disease of monoclonal plasma cells (PCs) and is characterized by uncontrolled proliferation of PCs and excessive production of specific types of immunoglobulins. Since PCs are terminally differentiated B cells, the World Health Organization (WHO) classifies MM as lymphoproliferative B-cell disease. The incidence of MM is 6-7 cases per 100,000 people in the world every year and the second most common cancer in the blood system. Due to the effects of drug resistance and malignant regeneration of MM cells in the microenvironment, all current treatment methods can prolong both overall and symptom-free survival rates of patients with MM but cannot cure MM. Both basic and clinical studies have proven that targeted therapy leads to a clear and significant prolongation of the survival of patients with MM, but when the disease recurs again, resistance to the previous treatment will occur. Therefore, the discovery of new targets and treatment methods plays a vital role in the treatment of MM. This article introduces and summarizes targeted MM therapy, potential new targets, and future precision medicine in MM.

Targeted Therapy

10.37349/etat.2021.00057

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Comparison of clinical characteristics and surgical outcomes in non‐vasectomized epididymal obstructive azoospermia patients with or without concurrent vas‐deferens obstruction

Andrology (2024)

Song-Xi Tang Qiang Chen Yi-Lang Ding Peng Yang Hailin Huang

Microsurgical vasoepididymostomy is an effective surgical method for treating epididymal obstructive azoospermia but the surgical outcomes can be affected in some non-vasectomized epididymal obstructive azoospermia patients with concurrent vas-deferens obstruction. This study aimed to explore the clinical characteristics and surgical outcomes in non-vasectomized epididymal obstructive azoospermia patients with versus without concurrent vas-deferens obstruction.

Vas deferens

Obstructive azoospermia

Vasectomy

Vasovasostomy

10.1111/andr.13734

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Analysis of the influence of a new type of buccal tube base mesh design on the adhesive layer stress distribution and bond strength

Journal of Adhesion Science and Technology (2020)

Yang Liu Shan Zhou Xiao Han Chengcheng Yan Zhenglong Lei

The three-dimensional finite element method was used to analyse the effect of changing the buccal tube baseplate shape on the stress magnitude and distribution at the interface between the buccal tube and the adhesive layer in a buccal tube-adhesive layer-tooth continuum under shear and tensile loads. A stress regression analysis was used to select the optimum mesh design and was verified by in vitro bond strength testing. This study involved buccal tubes with triangular mesh bases (100–400 µm mesh lengths, 100–200 µm mesh spacings, and 0, 45 and 90° angles) and a traditional quadrilateral mesh base. A finite element model of the buccal tube, adhesive layer and tooth were established. The stresses in the adhesive layer-buccal tube interface were recorded under mesial loads, distal loads, vertical loads and tensile loads. The average bond strength was measured by debonding the buccal tube with a universal testing machine and crosshead at a speed of 0.5 mm/min. Increasing the mesh length and mesh spacing decreased the von Mises stress and the first principal stress at the triangular mesh base-adhesive interface. Further analysis showed that the lowest stress and maximum mean bond strength were exhibited by the triangular mesh base (400 µm mesh length, 200 µm mesh spacing). Changes in the shape and size of the base grids affected the stress magnitude and distribution at the adhesive layer interface. The optimal triangular mesh base design in this study provides new ideas for clinical applications.

10.1080/01694243.2020.1742961

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Citations (4)