Ovella C. Ayers

National Cancer Institute

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Richard L. Cysyk

National Institutes of Health

Dale Shoemaker

National Institutes of Health

Richard H. Adamson

Atrex Energy (United States)

Anthony Kales

Pennsylvania State University

Tom S. Miya

Purdue University West Lafayette

Joseph Sivadjian

Sewa S. Legha

The University of Texas MD Anderson Cancer Center

Panos N. Kourounakis

Aristotle University of Thessaloniki

Jeanne Kostas

Costas R. Soldatos

Eginition Hospital

Cooperative Institutions

National Institutes of Health

National Cancer Institute

Pennsylvania State University

Penn State Milton S. Hershey Medical Center

Purdue University West Lafayette

University of Kentucky

Hershey (United States)

Université de Montréal

University of California, Los Angeles

The University of Texas MD Anderson Cancer Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Selective toxic effect of 4'-(9-acridinylamino)-methanesulfon-m- -ansidide (amsa, nsc 141549) on liver metastases in mice. Abstr.

DeWayne Shoemaker Ovella C. Ayers Melania D'Anna Richard L. Cysyk

Source

Cite

Citations (0)

Studies on the disposition of 2,3-dihydro-1H-imidazo [1,2-b] pyrazole in rodents

European Journal of Cancer (1965) (1981)

Dale Shoemaker Ovella C. Ayers Mary Ellen D'Anna Richard L. Cysyk

Pyrazole

10.1016/0014-2964(81)90247-4

Cite

Citations (3)

Salvage of circulating pyrimidine nucleosides by tissues of the mouse.

Journal of Biological Chemistry (1985)

James D. Moyer Nancy Malinowski Ovella C. Ayers

The metabolism of pyrimidine nucleosides present in the plasma of the mouse has been examined.Uridine and cytidine are rapidly cleared from the circulation with tn of <5 min.Uracil, deoxycytidine, deoxyuridine, and thymidine are cleared more slowly with tu of 9 to 13 min.Various tissues differed markedly in the extent of nucleotide formation from circulating nucleosides.Cytidine and uridine are predominantly converted to nucleotides (>50%) rather than catabolized, whereas uracil is almost entirely degraded.Thymidine, deoxyuridine, and deoxycytidine are intermediate in the extent of their conversion to nucleotides: 8.9 to 21% of these nucleosides are salvaged in the mouse.Both anabolic and catabolic routes are important in the metabolism of pyrimidine nucleosides in vivo.

10.1016/s0021-9258(18)89436-4

Cite

Citations (39)

Absorption of m-AMSA and its biliary metabolites from the rat small intestine

European Journal of Cancer and Clinical Oncology (1981)

Paul E. Gormley Dale Shoemaker Marcel Rozencweig Ovella C. Ayers Richard L. Cysyk

Enterohepatic circulation

Jejunum

10.1016/0014-2964(81)90299-1

Cite

Citations (2)

Oral Absorption and Selective Tissue Localization of 4’-(9-Acridinylamino)-methanesulfon-m-anisidide

Pharmacology (1978)

Richard L. Cysyk Dale Shoemaker Ovella C. Ayers Richard H. Adamson

The disposition of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (AMSA), a new antitumor agent presently undergoing clinical evaluation, was studied in mice and rats following oral administration and compared to that observed following intravenous administration. The metabolic fate of AMSA was the same with either intravenous or oral administration; however, the tissue distribution of AMSA differed significantly between the two routes of administration. Following absorption from the GI tract, AMSA was rapidly cleared from plasma by the liver and excreted in the bile as metabolites. Concentrations of AMSA in the liver were relatively high after oral administration and were sufficient to exert a cytotoxic effect on LI210 cells implanted at the site. The results indicate the use of AMSA orally to attain selective localization in the liver with decreased systemic exposure, which may prove useful against tumor metastases to the liver or primary hepatocellular carcinoma.

Clearance

10.1159/000136768

Cite

Citations (6)

Varia

Pharmacology (1978)

William F. Bousquet Costas R. Soldatos Anthony Kales Edward O. Bixler Martin B. Scharf

Book Reviews ponents of neural tissues; (IV) Biologically active amines.Together they cover a specific range of experi mental procedures for preparation, separation, isola tion, and analysis of nerve tissues, subunits, structural components, and of functionally important molecular components.Micromethods and cell or tissue culture technique are included as well.Each volume has its own subject index and is an independent unit, but there is of course a close interrelationship between the three editions, not only in respect to new develop ments and current trends in neurochemical methodol ogy.In total they serve as an up-to-date, valuable laboratory handbook for all scientists and technicians engaged in neurochemical research.

10.1159/000136774

Cite

Citations (0)

Book Reviews

Pharmacology (1978)

William F. Bousquet Costas R. Soldatos Anthony Kales Edward O. Bixler Martin B. Scharf

10.1159/000136773

Cite

Citations (0)

Effect of 5-benzylacyclouridine, a potent inhibitor of uridine phosphorylase, on the metabolism of circulating uridine by the isolated rat liver

Biochemical Pharmacology (1983)

Anne Monks Ovella C. Ayers Richard L. Cysyk