Lidia Chitimia‐Dobler

Institut für Mikrobiologie der Bundeswehr

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Gerhard Dobler

Institut für Mikrobiologie der Bundeswehr

Deon K. Bakkes

Onderstepoort Veterinary Institute

Malena Bestehorn

Institut für Mikrobiologie der Bundeswehr

Sabine Schaper

Universität der Bundeswehr München

Ben J. Mans

Onderstepoort Veterinary Institute

Christina Strübe

University of Veterinary Medicine Hannover, Foundation

Ute Mackenstedt

University of Hohenheim

Martin Pfeffer

Leipzig University

Olaf Kahl

Freie Universität Berlin

Andrea Springer

University of Veterinary Medicine Hannover, Foundation

Cooperative Institutions

Institut für Mikrobiologie der Bundeswehr

Universidad de Murcia

Ludwig-Maximilians-Universität München

Friedrich-Loeffler-Institut

German Center for Infection Research

Universität der Bundeswehr München

Czech Academy of Sciences, Institute of Microbiology

Leipzig University

University of Veterinary Medicine Hannover, Foundation

Centre National de la Recherche Scientifique

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Crimean-Congo haemorrhagic fever virus in Hyalomma impeltatum ticks from North Kordofan, the Sudan

International Journal of Infectious Diseases (2019)

Lidia Chitimia‐Dobler Makarim Habeeb Issa Malaz Esamalden Ezalden Idris Ahmed Yagoub Mohamed A. Abdalla

An evidence for Crimean-Congo hemorrhagic fever virus (CCHFV) was found in Hyalomma impeltatum ticks collected from sheep in North Kordofan in the Sudan. Based on sequencing of the partial segment S, the detected virus belongs to lineage I with closest similarity to CCHFV strains from Senegal. So far, this lineage is unknown in the Sudan.

Hyalomma

Crimean–Congo hemorrhagic fever

Lineage (genetic)

10.1016/j.ijid.2019.09.012

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Citations (11)

Tick‐Borne Encephalitis Virus Surveillance—Vaccination‐ and Infection‐Induced Seroprevalences in Western Austria 2024

Journal of Medical Virology (2024)

Anita Siller Lidia Chitimia‐Dobler Wolfgang Hitzl Manfred Astl Harald Schennach

Reported tick-borne-encephalitis (TBE) cases have been increasing in Western Austria, but no data are available on vaccination- and infection-specific seroprevalence. This study aimed to estimate current TBEV-seroprevalence in the region and inform prevention programs by comparing anti-NS1-based-incidence rates with reported case numbers and vaccination coverage. Between December 2023 and February 2024, serum samples from 4619 blood donors in Western Austria were collected and analyzed using TBEV- and WNV-IgG-ELISA assays. Seropositive samples were tested with a TBEV-anti-NS1-IgG-ELISA to distinguish infections from vaccinations. Borderline samples were retested with serum neutralization and triple-NS1-assays. The overall anti-TBEV-IgG-seroprevalence was 80.1% (95%CI 78.9-81.3); 2.7% (95%CI 2.3-3.2) of donors tested positive for anti-TBEV-NS1 IgG antibodies, indicating previous infection. The notified incidence rate in Western Austria was 2.7/100 000/year, compared to 136.2/100 000/year based on anti-TBEV-NS1-seropositive donors, denoting a substantial number of unreported cases (mean manifestation index 1.9%). The number of donors with TBEV-infections varied considerably by district, highlighting potential hotspots for TBEV-infections. The high anti-NS1-based, estimated annual TBE incidence rates show significant differences between districts, highlighting the need for targeted prevention programs. The high rate of undiagnosed TBE cases further suggests that estimated anti-NS1-based incidence rates should be considered when defining high-risk areas.

Seroprevalence

Tick-borne encephalitis

Tick-borne encephalitis virus

10.1002/jmv.70109

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Molecular detection of tick-borne pathogens in Rhipicephalus sanguineus sensu stricto collected from dogs in the steppe and high plateau regions of Algeria

Acta Tropica (2022)

AbdElkarim Laatamna Christina Strübe Deon K. Bakkes Sabine Schaper Fatima Zohra Aziza

Rhipicephalus sanguineus

Ehrlichia canis

Anaplasma phagocytophilum

Rickettsia conorii

10.1016/j.actatropica.2022.106582

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Ticks and Rickettsiae Associated with Wild Animals Sold in Bush Meat Markets in Cameroon

Pathogens (2023)

Archile Paguem Manchang Tanyi Kingsley Pierre Kamtsap Alfons Renz Sabine Schaper

Ticks are obligate blood-sucking parasites of wild animals and transmit many zoonotic microorganisms that can spread to domesticated animals and then to humans. In Cameroon, little is known about tick diversity among wildlife, especially for animals which are hunted for human consumption. Therefore, this survey was undertaken to investigate tick and Rickettsia species diversity parasitizing the wild animals sold in bush meat markets in Cameroon. In total, 686 ticks were collected and identified to the species level based on morphology, and some were genetically analyzed using the 16S rRNA gene. Eighteen tick species belonging to five genera were identified: Amblyomma spp. (Amblyomma compressum, Amblyomma flavomaculatum, and Amblyomma variegatum), Haemaphysalis spp. (Haemaphysalis camicasi, Haemaphysalis houyi, Haemaphysalis leachi, and Haemaphysalis parmata), Hyalomma spp. (Hyalomma nitidum, Hyalomma rufipes, and Hyalomma truncatum), Ixodes spp. (Ixodes rasus and Ixodes moreli), and Rhipicephalus spp. (Rhipicephalus guilhoni, Rhipicephalus moucheti, Rhipicephalus muhsamae, Rhipicephalus microplus, Rhipicephalus camicasi, and Rhipicephalus linnaei). In terms of Rickettsia important for public health, two Rickettsia spp., namely Rickettsia aeschlimannii and Rickettsia africae, were detected in Hyalomma spp. and Amblyomma spp., respectively. Distinct tick–pathogen patterns were present for divergent sequences of R. africae associated with exclusively A. variegatum vectors (type strain) versus vectors comprising A. compressum, A. flavomaculatum, and A. variegatum. This suggests possible effects of vector species population dynamics on pathogen population circulation dynamics. Furthermore, Candidatus Rickettsia africaustralis was detected for the first time in Cameroon in I. rasus. This study highlights the high diversity of ticks among wildlife sold in bush meat markets in Cameroon.

Haemaphysalis

Amblyomma variegatum

Amblyomma

Rhipicephalus

Hyalomma

Rhipicephalus sanguineus

10.3390/pathogens12020348

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Citations (9)

Amblyomma birmituma new species of hard tick in Burmese amber

Parasitology (2017)

Lidia Chitimia‐Dobler Bruno Cancian de Araújo Bernhard Ruthensteiner Timo Pfeffer Jason A. Dunlop

SUMMARY Amblyomma birmitum sp. nov. is formally described as a new record from 99 Ma old Burmese amber from Myanmar. This confirms the presence of the extant hard tick genus Amblyomma C.L. Koch, 1844 (Ixodida: Ixodidae) in the Late Cretaceous. This discovery is placed in its wider context and some reports of fossil hard ticks, such as a Hyalomma C.L. Koch, 1844 in Eocene Baltic amber, are misidentifications. The genus Amblyomma belongs to the clade Metastriata, a group which probably also accommodates two extinct genera, Cornupalpatum Poinar and Brown, 2003 and Compluriscutata Poinar and Buckley, 2008, also found in Burmese amber. All three fossils are thus only a little younger than published molecular divergence time estimates (ca. 124 ± 17 Ma) for the Metastriata lineage. Amblyomma has a largely Gondwanan distribution today. However, in some biogeographical scenarios, e.g. the Samafrica model, its predicted radiation time postdates the dissolution of the original Gondwana supercontinent raising questions about how its current distribution pattern was achieved.

Baltic amber

Amblyomma

Hyalomma

10.1017/s0031182017000853

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Citations (36)

Chapter 3: Transmission/Natural cycle

Deleted Journal (2022)

Lidia Chitimia‐Dobler Ute Mackenstedt Olaf Kahl

The natural cycle of the TBE virus is dependent on vector ticks and reservoir hosts. There are differing transmission cycles in varying environments, from cold northern coniferous forests to temperate central European forests. Within a natural transmission cycle, there are different ways of transmission: tick-to-tick (transovarial, sexual), host-to-tick (viremic), and also tick-to-tick and host-to-host. The complexity of natural transmission cycles is inadequately explored and poorly understood.

Transovarial transmission

Natural cycle

10.33442/26613980_3-5

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Metaflumizone – a new ectoparasiticide for dogs and cats

DOAJ (DOAJ: Directory of Open Access Journals) (2007)

Lidia Chitimia‐Dobler I. Cosoroabă

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First detection of Rickettsia conorii ssp. caspia in Rhipicephalus sanguineus in Zambia

Parasitology Research (2017)

Lidia Chitimia‐Dobler Gerhard Dobler Sabine Schaper Thomas Küpper Simone Kattner

Rickettsia conorii

Rhipicephalus sanguineus

Boutonneuse fever

10.1007/s00436-017-5639-z

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Citations (13)

Genetic analysis of Rhipicephalus sanguineus sensu lato ticks, parasites of dogs in the Canary Islands, Cyprus, and Croatia, based on mitochondrial 16S rRNA gene sequences

Parasitology Research (2019)

Lidia Chitimia‐Dobler Lina Kurzrock Tomáš Molčányi Ramona Rieß Ute Mackenstedt

Rhipicephalus sanguineus

Sensu

Rhipicephalus

Lineage (genetic)

10.1007/s00436-019-06214-z

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Citations (12)

The complex interplay of climate, TBEV vector dynamics and TBEV infection rates in ticks—Monitoring a natural TBEV focus in Germany, 2009–2018

PLoS ONE (2021)

J Borde Klaus Kaier Philip Hehn Andreas Matzarakis Stefan Frey

Background Tick-borne encephalitis (TBE) is the most important tick-borne viral disease in Eurasia and causes disease in humans and in a number of animals, among them dogs and horses. There is still no good correlation between tick numbers, weather conditions and human cases. There is the hypothesis that co-feeding due to simultaneous occurrence of larvae and nymphs may be a factor for the increased transmission of the virus in nature and for human disease. Based on long-term data from a natural TBEV focus, phylogenetic results and meteorological data we sought to challenge this hypothesis. Methods Ticks from an identified TBE natural focus were sampled monthly from 04/2009 to 12/2018. Ticks were identified and pooled. Pools were tested by RT-qPCR. Positive pools were confirmed by virus isolation and/or sequencing of additional genes (E gene, NS2 gene). Temperature data such as the decadal (10-day) mean daily maximum air temperature (DMDMAT) were obtained from a nearby weather station and statistical correlations between tick occurrence and minimal infection rates (MIR) were calculated. Results In the study period from 04/2009 to 12/2018 a total of 15,530 ticks (2,226 females, 2,268 males, 11,036 nymphs) were collected. The overall MIR in nymphs over the whole period was 77/15,530 (0.49%), ranging from 0.09% (2009) to 1.36% (2015). The overall MIR of female ticks was 0.76% (17/2,226 ticks), range 0.14% (2013) to 3.59% (2016). The overall MIR of males was 0.57% (13/2,268 ticks), range from 0.26% (2009) to 0.97% (2015). The number of nymphs was statistically associated with a later start of spring/vegetation period, indicated by the onset of forsythia flowering. Conclusion There was no particular correlation between DMDMAT dynamics in spring and/or autumn and the MIR of nymphs or adult ticks detected. However, there was a positive correlation between the number of nymphs and the number of reported human TBE cases in the following months, but not in the following year. The hypothesis of the importance of co-feeding of larvae and nymphs for the maintenance of transmission cycle of TBEV in nature is not supported by our findings.

Tick-borne encephalitis virus

10.1371/journal.pone.0244668

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Citations (24)