Angela Mayoral

Unió Catalana de Centres de Desenvolupament Infantil i Atenció Precoç

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Deepak Saxena

Indian Institute of Public Health Gandhinagar

Patricia Corby

University of Pittsburgh

Lidia Glodzik

Cornell University

Sebastián Videla

Hospital Universitari Germans Trias i Pujol

Juan Fortea

Hospital de Sant Pau

Miriam R. Robbins

University of Pennsylvania

Bessy Benejam

Unió Catalana de Centres de Desenvolupament Infantil i Atenció Precoç

María Carmona‐Iragui

Universitat Autònoma de Barcelona

Mony J. de Leon

Weill Cornell Medicine

Ronald G. Craig

New York University

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New York University

University of Pennsylvania

Hospital de Sant Pau

Biomedical Research Networking Center on Neurodegenerative Diseases

Universitat Autònoma de Barcelona

Centro de Investigación Biomédica en Red

Unió Catalana de Centres de Desenvolupament Infantil i Atenció Precoç

Biomedical Research Institute

John Wiley & Sons (United States)

NYU Langone Health

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Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring (2016)

Angela R. Kamer Juan Fortea Sebastián Videla Angela Mayoral Malvin N. Janal

Abstract People with Down syndrome (DS) are at an increased risk for Alzheimer's disease (AD). After 60 years of age, >50% of DS subjects acquire dementia. Nevertheless, the age of onset is highly variable possibly because of both genetic and environmental factors. Genetics cannot be modified, but environmental risk factors present a potentially relevant intervention for DS persons at risk for AD. Among them, inflammation, important in AD of DS type, is potential target. Consistent with this hypothesis, chronic peripheral inflammation and infections may contribute to AD pathogenesis in DS. People with DS have an aggressive form of periodontitis characterized by rapid progression, significant bacterial and inflammatory burden, and an onset as early as 6 years of age. This review offers a hypothetical mechanistic link between periodontitis and AD in the DS population. Because periodontitis is a treatable condition, it may be a readily modifiable risk factor for AD.

Pathogenesis

10.1016/j.dadm.2016.01.001

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