Deepak Ganjewala

Amity University

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Gauri Srivastava

Amity University

Rajesh Luthra

Central Institute of Medicinal and Aromatic Plants

Ashish Kumar Gupta

Central Agricultural University

Ruchika Mittal

Amity University

Gurminder Kaur

Institute of Engineering

S. Asha Devi

Vellore Institute of Technology University

Shiv Kumar

Praveen C. Verma

National Botanical Research Institute

Hina Bansal

Amity University

Anjali Rai

National Institute of Diabetes and Digestive and Kidney Diseases

Cooperative Institutions

Amity University

Indian Agricultural Research Institute

Council of Scientific and Industrial Research

Aligarh Muslim University

Academy of Scientific and Innovative Research

Chicago State University

Indian Council of Agricultural Research

Banaras Hindu University

National Botanical Research Institute

Vellore Institute of Technology University

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Study on Phytochemical Composition, Antibacterial and Antioxidant Properties of Different Parts of Alstonia scholaris Linn.

DOAJ (DOAJ: Directory of Open Access Journals) (2013)

Deepak Ganjewala Ashish Kumar Gupta

To evaluate phytochemical composition, antibacterial and antioxidant properties of methanolic extracts of different parts viz., leaves, follicles and latex of Indian devil tree (Alstonia scholaris Linn.) R. Br.Antibacterial activities of the methanol extracts against Gram +ve (Bacillus subtilis and Staphylococcus aureus) and Gram -ve (Escherichia coli, Pseudomonas aeruginosa) bacteria were determined by well diffusion techniques. Aantioxidant profiles of methanol extracts were determined by 1,1-diphenyl-2-picryl-hydrazil (DPPH) free radical scavenging, superoxide anion radial scavenging and ferric thiocyanate reducing assays.Phytochemical composition revealed abundance of flavonoids (97.3 mg QE/g DW), proanthocynidins (99.3 mg CE/g DW) and phenolics (49.7 mgGAE/g DW) in the leaf extract. Extracts of follicles and latex had comparatively very content of phenolics, flavonoids and proanthocyanidins. However, in follicle extract level of proanthocyanidins was significantly higher (46.8 mg CE/gDW). Latex extract among others exhibited most potent antibacterial activity. All the extracts displayed strong DPPH free radical and superoxide anion scavenging activities, only leaf extract displayed powerful reducing and ferrous ion chelating activities.Study revealed significant antioxidant activities of A. scholaris leaf, follicles and latex extracts and potential antibacterial activity of latex extract.

Phytochemical

Agar diffusion test

10.5681/apb.2013.061

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Citations (17)

Unraveling of inhibitory potential of phytochemicals against SARS-CoV-2 using in-silico approach

Elsevier eBooks (2022)

Deepak Ganjewala Hina Bansal Ruchika Mittal Gauri Srivastava

Lopinavir

Cysteine protease

Ritonavir

Coronavirus

10.1016/b978-0-323-90572-5.00012-3

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Citations (0)

Phytochemical Composition and Antioxidant Properties of Methanol Extracts of Leaves and Fruits ofNeolamarckia cadamba(Roxb.)

Journal of Biologically Active Products from Nature (2013)

Deepak Ganjewala Niharika Tomar Ashish Kumar Gupta

(2013). Phytochemical Composition and Antioxidant Properties of Methanol Extracts of Leaves and Fruits of Neolamarckia cadamba (Roxb.) Journal of Biologically Active Products from Nature: Vol. 3, No. 4, pp. 232-240.

Phytochemical

10.1080/22311866.2013.817748

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Citations (16)

An Update on Transcriptome Sequencing of Hairy Root Cultures of Medicinally Important Plants

Springer eBooks (2018)

Deepak Ganjewala Gurminder Kaur Praveen C. Verma

Catharanthus roseus

Methyl jasmonate

Hairy Root Culture

Rehmannia glutinosa

Secondary metabolism

Artemisia annua

Vindoline

10.1007/978-981-13-2562-5_13

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A Study on Antimicrobial Activities of Essential Oils of Different Cultivars of Lemongrass (Cymbopogon flexuosus)

Pharmaceutical Sciences (2016)

Ashish Kumar Gupta Ritam Muhury Deepak Ganjewala

Background: Cymbopogon flexuosus popularly known as lemongrass provides a lemon scented essential oil which is widely used in flavour and fragrance, perfumery, food and pharmaceuticals. The aim of the present study was to assess antimicrobial activities of essential oils of three lemongrass cultivars viz., Pragati, Praman and Suvarna. Methods: Essential oils were isolated from one month old plants by hydro-distillation in mini Clevenger apparatus for 2 h. Antimicrobial activities were determined by agar well diffusion method Results: Lemongrass oils exhibited strong antimicrobial activity against all the microbes except E coli. Mean inhibition zone diameter (mm) against bacteria was ranged 27-38 mm. B. Subtilis was the most sensitive bacterium to all essential oils. Essential oils also showed strong antifungal effects against both A. niger and C. albicans with mean inhibition zone diameter (mm) values 20-26 and 27-29 mm, respectively. Statistical analyses revealed that antimicrobial activity shown by essential oils were significant (p < 0.05) against all microorganisms except B. subtilis and C. albicans (p >> 0.05). Conclusion: The study revealed strong antimicrobial potential of the essential oil against pathogenic microbial strains which may be of high clinical importance in future.

Agar diffusion test

10.15171/ps.2016.26

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Antibacterial Properties of Lemongrass (Cymbopogon flexuosusSteud) Wats Essential Oils in Single form and Combination of Honey Against Drug Resistant Pathogenic Bacteria

Journal of Biologically Active Products from Nature (2014)

Deepak Ganjewala Ruchika Mittal Ashish Kumar Gupta Martha Premlatha Reetika Dawar

AbstractAntibacterial potential of four lemongrass essential oils (EOs) and their major oil constituent, citral in single form and in combination of honey were evaluated against multi drug resistant (MDR) bacteria Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus. The antibacterial potentials determined using agar well diffusion method has revealed that Krishna EOs exhibited most potent bactericidal effects than other Eos against all MDR bacteria used. The diameter of zone of inhibition of Krishna EOs ranged from 44-50 mm/50 µL of EOs. However, EOs of Pragati and Suvarna were selectively effective against S. aureus while that of Nima against A. baumannii and P. aeruginosa. Citral expressed better antibacterial potential against all the MDR bacteria with zone of inhibition 38-45 mm/50 µl. The combination of all four different EOs with honey showed pronounced antibacterial activity exclusively against S. aureus. The combination of Suvarna EOs and honey showed 22 % increase in antibacterial activity against A. baumannii than the EOs alone. The combination of citral and honey showed significantly lower antibacterial activity as compared to citral alone against all MDR bacteria used. The minimum inhibitory concentrations of EOs determined were 4.5 µg/ml. Thus, the study revealed enhanced antibacterial potential of lemongrass EO when they are used with honey against drug resistant S. aureus.Key words: Antibacterialcitralessential oilhoneylemongrassmulti drug resistantzone of inhibition

Citral

Acinetobacter baumannii

Agar diffusion test

Pathogenic bacteria

Minimum bactericidal concentration

10.1080/22311866.2014.933083

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Cross-species virus transmission and its pandemic potential

Bulletin of the National Research Centre/Bulletin of the National Research Center (2022)

Priyanka Ray Choudhury Tapoja Saha Sachin Goel Janvi Manish Shah Deepak Ganjewala

The majority of pandemics are known to be a result of either bacteria or viruses out of which viruses seem to be an entity of growing concern due to the sheer number of yet unidentified and potentially threatening viruses, their ability to quickly evolve and transform, their ability to transfer and change from one host organism to another and the difficulty in creating safe vaccines on time.The present review attempts to bring forth the potential risks, prevention and its impact on the global society in terms of sociological and economic parameters. Taking hindsight from previously as well as ongoing current viral epidemics, this article aims to draw a concrete correlation between these viruses in terms of their origin, spread and attempts to compare how much they can affect the population. The study also assesses the worst-case scenarios and the amount of preparedness, required to fight against such pandemics and compares the required amount of preparedness to the current precautions and measures by different governments all across the world.Learning from the current pandemic, we can implement certain measures to prevent the adverse effects of pandemics in the future and through severe preparedness can combat the challenges brought about by the pandemic.

Pandemic

10.1186/s42269-022-00701-7

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An Update on Chemical Composition and Bioactivities of Acorus Species

Asian Journal of Plant Sciences (2011)

Deepak Ganjewala Ashwani Kumar Srivastava

10.3923/ajps.2011.182.189

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Citations (22)

Preliminary Characterization of Melanin Isolated from Fruits and Seeds of <i>Nyctanthes arbor-tristis</i>

Journal of Scientific Research (2009)

P. Kannan Deepak Ganjewala

Melanin from Nyctanthes arbor-tristis fruits and seeds was isolated and purified by alkaline extraction, acid hydrolysis and organic solvents. Each, fruit and seed yielded melanin 50 mg/100g tissue weight. The melanins of fruit and seeds were analyzed by UV-visible and infrared (IR) spectroscopy for characterization. The IR spectrum of fruit and seed melanins did not match with each other and the seed melanin could be distinguished by their sharp peat at 285 nm from the fruit melanin in IR spectrum. Two melanins have shown absorptions above and below 1600 cm-1 in their respective IR spectrum. The melanins thus characterized were tested for their stability after incubating at different temperatures and in presence of oxidants (KMnO4 and K2Cr2O7) and metal ions (Mg++ and Zn++) for a specified period. The stability of the melanin was assessed by measuring changes in the absorbance at 285 nm. The results revealed that the fruit melanin was more stable at 50 ºC while the seed melanin was quite stable at 25 ºC. However, their stability was markedly affected by oxidants and metal ions. Keywords: Melanin; Nyctanthes arbor-tristis; UV-visible spectroscopy; IR-spectroscopy; Oxidant. © 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v1i3.2005 J. Sci. Res. 1 (3), 655-661 (2009)

Absorbance

10.3329/jsr.v1i3.2005

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Citations (21)

Antimicrobial activity of Acorus calamus (L.) rhizome and leaf extract.

Acta Biologica Szegediensis (2009)

S. Asha Devi Deepak Ganjewala

Antimicrobial activity of Acorus calamus rhizome and leaf extracts obtained with different solvents viz., petroleum ether, chloroform, hexane and ethyl acetate was evaluated. Extracts obtained with ethyl acetate among others were found to be highly effective. Rhizomes and leaf ethyl acetate extracts exhibited pronounced antifungal activity with diameter zone of inhibition ranged from 20-28 and 18-25 mm as well as antiyeast activity with diameter zone of inhibition ranged from 22-25 and 20-23 mm, respectively. The minimum inhibitory concentration (MIC) of the rhizome and leaf extracts for antifungal activity measured was 2-4mg/ml, except Penicillium chrysogenum whereas against yeasts was relatively higher, 4-5 and 6-8 mg/ml. MIC value for antibacterial activity was comparatively very high ~16-42 mg/ml. In addition, authentic A- and B-asarones were also tested for their antimicrobial potential. Both A- and B-asarones exhibited very strong antimicrobial activities against the fungi and yeasts than those of rhizome and leaf extracts. The study clearly suggested that A. calamus rhizomes and leaves must possess active principle A- and B-asarones which is believed to be responsible for their antimicrobial ac- tivities. Both rhizomes and leaf extracts, however, had no antibacterial activity except E. coli.

Acorus calamus

Calamus

Petroleum ether

Penicillium chrysogenum

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