콘택트렌즈 착용 후 발생한 Acinetobacter Baumannii 각막염 1예김성택․이영창․허 준․고재웅 조선대학교 의과대학 안과학교실 목적: 국내 최초로 콘택트렌즈를 착용한 환자에서 Acinetobacter baumannii 각막염을 경험하여 보고하고자 한다.증례요약: 17세 남자환자로, 4개월 전 연성 콘택트렌즈를 착용하기 시작한 후, 2일전부터 시작된
Abstract In this study, a bulk fin-type FET (FinFET)-based capacitorless one-transistor dynamic random-access memory (1T-DRAM) was proposed. The fabrication process of the proposed 1T-DRAM was similar to that of a typical junctionless bulk FinFETs, except that the p-type doped body fin region operated as a charge storage region. The effects of the geometrical variations, such as the fin angle ( θ fin ) variation and line edge roughness (LER), which are inevitable in fabrication, on the transfer characteristics and memory performance of the proposed 1T-DRAM were studied. θ fin was varied from 90° to 80°, and 200 samples with the LER were analyzed. Results revealed that the transfer characteristics and memory performance were affected by geometrical variations. However, the proposed 1T-DRAM exhibited an excellent retention time in all cases because the charge storage region was separated from the region of operation.
during a thromboembolic event.Thromboembolic events occurred in 5 (86%) of the 7 patients with thrombophilia, and 1 in a patient without thrombophilia.In addition, 4 ischaemic strokes, 1 central retinal artery thrombosis, 1 venous sinus thrombosis, 1 jugular venous thrombosis, and 1 transient ischaemic attack were recorded.In addition, 1 patient showed positive anti-β2 microglobulin antibody; 3 showed positive lupus anticoagulant with MTHFR C677T homozygosity; 1 MTHFR C677T homozygosity, 1 positive lupus anticoagulant with MTHFR C677T heterozygosity; and 1 with positive lupus anticoagulant and MTHFR A1298C and C677T heterozygosity.Amongst the patients with thromboembolic events, 5 had Crohn's disease and 1 ulcerative colitis.The average age was 45.6 years with an average disease-evolution time of 61.2 months.The average Harvey-Bradshaw score was 5.4, and Mayo score was 11.Average erythrocyte sedimentation rate was 23 mm, and C-reactive protein was 2.97 mg/dL.It was necessary to optimise therapeutic in 2 patients.Conclusions: In our study, most of the patients with IBD and thrombophilias presented a thromboembolic event.Thromboembolic events were more frequent in Crohn's disease, with highest clinical activity scores.
Pgrmc1 is a non-canonical progesterone receptor related to the lethality of various types of cancer. PGRMC1 has been reported to exist in co-precipitated protein complexes with epidermal growth factor receptor (EGFR), which is considered a useful therapeutic target in hepatocellular carcinoma (HCC). Here, we investigated whether Pgrmc1 is involved in HCC progression. In clinical datasets, PGRMC1 transcription level was positively correlated with EGFR levels; importantly, PGRMC1 level was inversely correlated with the survival duration of HCC patients. In a diethylnitrosamine (DEN)-induced murine model of HCC, the global ablation of Pgrmc1 suppressed the development of HCC and prolonged the survival of HCC-bearing mice. We further found that increases in hepatocyte death and suppression of compensatory proliferation in the livers of DEN-injured Pgrmc1-null mice were concomitant with decreases in nuclear factor κB (NF-κB)-dependent production of interleukin-6 (IL-6). Indeed, silencing of Pgrmc1 in murine macrophages led to reductions in NF-κB activity and IL-6 production. We found that the anti-proinflammatory effect of Pgrmc1 loss was mediated by reductions in EGFR level and its effect was not observed after exposure of the EGFR inhibitor erlotinib. This study reveals a novel cooperative role of Pgrmc1 in supporting the EGFR-mediated development of hepatocellular carcinoma, implying that pharmacological suppression of Pgrmc1 may be a useful strategy in HCC treatment.
Microbial fuel cells (MFCs) are gaining tremendous interests for achieving simultaneous power production and recalcitrant wastewaters treatment. In this study, simultaneous electricity generation and tetra-azo dye (Direct Red 80) decolorization was examined in a dual chamber MFC. In addition, glucose and various volatile fatty acids were separately examined as co-substrates for anaerobic dye degradation and bioelectricity generation. Maximum power of 477.8 and 455.7 mW/m2 were attained with glucose (1,000 mg/L) as a sole carbon source and glucose (1,000 mg/L) coupled with dye (200 mg/L), respectively. At this glucose and dye initial concentration, 85.8% color and 74.9% COD removal were resulted in 48 h batch studies. Color removal without any co-substrate's addition was 23%, indicating dye was degraded mainly in the presence of carbon sources. There was no substantial negative effect in electricity generation was observed with the dye degradation. Dye removal was decreased with the increase in dye initial concentration (25–800 mg/L) and increases notably with the increase in initial glucose concentration between 0 and 1,000 mg/L, while afterward insignificant effect up to 2,000 mg/L was observed. Glucose was determined as better co-substrate followed by acetic, propionic, and lactic acid in terms of dye removal and maximum power production. Gas chromatography-mass spectrometry showed sodium 4-aminoazobenzene-4′-sulfonate to be the subsequent metabolites formed during the decolorization of dye. This work demonstrated that MFC could be applied to achieve electricity generation and simultaneous azo dye degradation using glucose as the preferred co-substrate.
Two new phenolic compounds, 4-O-glucopyranosyl-5-O-caffeoylshikimic acid (1) and 2,3-digalloyl oregonin (2), were isolated along with eight known phenolic compounds (3-10) from an 80% acetone extract of Alnus sibirica leaves. The chemical structures of these compounds were elucidated using 1D/2D nuclear magnetic resonance and high resolution-MS. The anti-oxidative activities of these compounds were determined by assaying their 1,1-diphenyl-2-picrylhydrazyl radical and nitroblue tetrazolium superoxide anion scavenging activity. All of the isolated phenolic compounds (1-10) exhibited potent anti-oxidative activities. In particular, 2 and 4, which are diarylheptanoids, and 10 which is ellagitannin exhibited excellent anti-oxidative activities with almost the same potency as that of the positive controls L-ascorbic acid and allopurinol.
Although, the prevalence of Helicobacter pylori infection in Korea has declined owing to the eradication therapy, recent seropreva-lence of H. pylori infection is still reported to be as high as 54.4%. Until now, "standard regimen" for eradication of H. pylori has been conventional triple therapy consisting of proton pump inhibitor, amoxicillin, and clarithromycin. However, with the increase in antibiotic resistance, especially against clarithromycin, the eradication rate of conventional triple therapy has steadily declined during the past 13 years in Korea. Present eradication rate of standard triple therapy is reported to be less than 80%, which is the Maginot line of efficacy for the currently available regimen. Therefore, new first line eradication regimen is needed to enhance the eradication rate of H. pylori infection.
Yoon Suk Lee, Chang Min Cho, Kwang Bum Cho, Jun Heo, Min Kyu Jung, Sung Bum Kim, Kook Hyun Kim, Tae Nyeun Kim, Dong Wook Lee, Jimin Han, Ho Gak Kim, Daejin Kim, and Hyunsoo Kim. Gut and Liver 2021;15:459-65. https://doi.org/10.5009/gnl19304
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