Giorgio Lo Russo

Centro Cardiologico Monzino

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i-10 index

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Author Order

Document Type

Co-Authors

Laura Tassi

Ospedale Maggiore

105

Stefano Francione

Istituto Giannina Gaslini

Massimo Cossu

Istituto Giannina Gaslini

Francesco Cardinale

Ospedale Maggiore

Lino Nobili

Istituti di Ricovero e Cura a Carattere Scientifico

Roberto Mai

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Ivana Sartori

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Laura Castana

Ospedale Maggiore

Veronica Pelliccia

Ospedale Maggiore

Francesca Gozzo

Ospedale Maggiore

Cooperative Institutions

Neurological Surgery

233

Istituti di Ricovero e Cura a Carattere Scientifico

157

University of Milan

125

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Fondazione IRCCS Istituto Neurologico Carlo Besta

Ospedale Maggiore

Johns Hopkins University

University of Bologna

Johns Hopkins Medicine

Harvard University

Author Statistics

Papers

Citation

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Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

New England Journal of Medicine (2017)

Ingmar Blümcke Roberto Spreafico Gerrit Haaker Roland Coras Katja Kobow

Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy.We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%).The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients.In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.).

Hippocampal sclerosis

Neuropathology

Histopathology

10.1056/nejmoa1703784

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Citations (740)

Declarative long-term memory and the mesial temporal lobe: Insights from a 5-year postsurgery follow-up study on refractory temporal lobe epilepsy

Epilepsy & Behavior (2016)

Gerardo Salvato Pina Scarpa Stefano Francione Roberto Mai Laura Tassi

Hippocampal sclerosis

10.1016/j.yebeh.2016.08.029

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Citations (17)

Individually tailored extratemporal epilepsy surgery in children: Anatomo-electro-clinical features and outcome predictors in a population of 53 cases

Epilepsy & Behavior (2012)

Alexandra Liava Stefano Francione Laura Tassi Giorgio Lo Russo Massimo Cossu

Stereoelectroencephalography

10.1016/j.yebeh.2012.05.008

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Citations (51)

[Multicenter study on bronchopneumonia treated in a hospital environment in Friuli-Venezia Giulia: 1) Epidemiology].

PubMed (1986)

Giana Zarbato Longo R Strinati D. Faraguna G Borgnolo S Cadorini

Results are presented of a vast analysis into Bronchopneumonia (B.P.) conducted in North East Italy as activity of the Regional Section of the Italian Paediatric Society. The survey of the 14 Paediatric Centres in the Friuli Venezia Giulia Region, produced a total of 536 cases of B.P. in the period January-December 1982. Some significant connections between the several epidemiologic parameters investigated, with special interest in length of hospitalization, are commented. Bed occupancy, short vs. long stays, efficient management are discussed having also in consideration specific possible necessities of some local communities.

Bronchopneumonia

Occupancy

Source

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Citations (0)

Epileptic motor behaviors during sleep: Anatomo-electro-clinical features

Sleep Medicine (2011)

Paola Proserpio Massimo Cossu Stefano Francione Francesca Gozzo Giorgio Lo Russo

Stereoelectroencephalography

Frontal lobe

Pathognomonic

Occipital lobe

10.1016/j.sleep.2011.10.018

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Citations (46)

Uncovering the fast, directional signal flow through the human temporal pole during semantic processing

Scientific Reports (2023)

Paul Tiesinga Artem Platonov Veronica Pelliccia Giorgio Lo Russo Ivana Sartori

Abstract The temporal pole (TP) plays a central role in semantic memory, yet its neural machinery is unknown. Intracerebral recordings in patients discriminating visually the gender or actions of an actor, yielded gender discrimination responses in the ventrolateral (VL) and tip (T) regions of right TP. Granger causality revealed task-specific signals travelling first forward from VL to T, under control of orbitofrontal cortex (OFC) and neighboring prefrontal cortex, and then, strongly, backwards from T to VL. Many other cortical regions provided inputs to or received outputs from both TP regions, often with longer delays, with ventral temporal afferents to VL signaling the actor’s physical appearance. The TP response timing reflected more that of the connections to VL, controlled by OFC, than that of the input leads themselves. Thus, visual evidence for gender categories, collected by VL, activates category labels in T, and consequently, category features in VL, indicating a two-stage representation of semantic categories in TP.

SIGNAL (programming language)

10.1038/s41598-023-33318-5

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Citations (2)

Insular-opercular seizures manifesting with sleep-related paroxysmal motor behaviors: A stereo-EEG study

Epilepsia (2011)

Paola Proserpio Massimo Cossu Stefano Francione Laura Tassi Roberto Mai

Sleep-related complex motor seizures are a common feature of nocturnal frontal lobe epilepsy. Nevertheless, recent studies also suggest that sleep-related hypermotor seizures can originate in the insula. The present study describes the electroclinical features of eight drug-resistant epileptic patients with insular-opercular seizures manifesting with nocturnal complex motor seizures.Patients underwent a comprehensive presurgical evaluation, which included history, interictal electroencephalography (EEG), scalp video-EEG monitoring, high-resolution magnetic resonance imaging (MRI), and intracerebral recording by stereo-EEG.Almost all patients reported an initial sensation consisting of viscerosensitive or somatosensory symptoms. Ictal clinical signs were represented by tonic-dystonic asymmetric posturing and/or hyperkinetic automatisms, including bimanual/bipedal activity and ballistic movements. Some patients exhibited dysarthric speech, hypersalivation, and apnea. Interictal and ictal EEG provided lateralizing information in the majority of patients. In three patients, MRI showed a focal anatomical abnormality in the insular-opercular region. Stereo-EEG ictal recordings demonstrated that the epileptic discharge involved simultaneously the insular cortex and the opercular region. Complex motor manifestations appeared when the ictal discharge showed an extrainsular spreading to frontomesial regions (cingulum, superior frontal gyrus, and supplementary motor area) and/or to internal and neocortical temporal lobe structures. Six patients received an insular-opercular cortical resection; three of them are seizure free (minimum follow-up 24 months) and in one a marked reduction in seizure frequency was obtained. Two patients have been operated on recently. Histology revealed a focal cortical dysplasia in three patients. One patient excluded from surgery died for sudden unexpected death in epilepsy during sleep.Our data strengthen the concept that sleep-related complex motor attacks can originate in the insula, and provide useful electroclinical information to differentiate this localization from those with similar clinical characteristics. Furthermore, this study indicates that in these drug-resistant patients, surgical treatment represents a highly effective treatment option.

Precentral gyrus

Insular cortex

10.1111/j.1528-1167.2011.03254.x

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Citations (119)

A method for the assessment of time-varying brain shift during navigated epilepsy surgery

International Journal of Computer Assisted Radiology and Surgery (2015)

Elena De Momi Giancarlo Ferrigno Giampiero Bosoni P. Bassanini P. Blasi

Position (finance)

Image-guided surgery

Midline shift

10.1007/s11548-015-1259-1

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Citations (13)

SEEG, Happy Anniversary!

World Neurosurgery (2015)

Francesco Cardinale Jorge González-Martínez Giorgio Lo Russo

Stereoelectroencephalography

Stereotaxy

10.1016/j.wneu.2015.11.029

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Citations (15)

Focal lesions induce large-scale percolation of sleep-like intracerebral activity in awake humans

NeuroImage (2021)

Simone Russo Andrea Pigorini Ezequiel Mikulan Simone Sarasso A Rubino

Focal cortical lesions are known to result in large-scale functional alterations involving distant areas; however, little is known about the electrophysiological mechanisms underlying these network effects. Here, we addressed this issue by analysing the short and long distance intracranial effects of controlled structural lesions in humans. The changes in Stereo-Electroencephalographic (SEEG) activity after Radiofrequency-Thermocoagulation (RFTC) recorded in 21 epileptic subjects were assessed with respect to baseline resting wakefulness and sleep activity. In addition, Cortico-Cortical Evoked Potentials (CCEPs) recorded before the lesion were employed to interpret these changes with respect to individual long-range connectivity patterns. We found that small structural ablations lead to the generation and large-scale propagation of sleep-like slow waves within the awake brain. These slow waves match those recorded in the same subjects during sleep, are prevalent in perilesional areas, but can percolate up to distances of 60 mm through specific long-range connections, as predicted by CCEPs. Given the known impact of slow waves on information processing and cortical plasticity, demonstrating their intrusion and percolation within the awake brain add key elements to our understanding of network dysfunction after cortical injuries.

Stereoelectroencephalography

Sleep

10.1016/j.neuroimage.2021.117964

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Citations (51)