Omar P. Sangüeza

Wake Forest University

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Luís Requena

Universidad Autónoma de Madrid

101

Nada Shaker

University of California, San Francisco

Luis Requena

Hospital Universitario Fundación Jiménez Díaz

Heinz Kutzner

Dermatopathologie Friedrichshafen

Dinesh Pradhan

University of Nebraska Medical Center

Nuha Shaker

University of Pittsburgh

Rita O. Pichardo

Wake Forest University

Christine Ahn

Wake Forest University

Robert Phelps

Icahn School of Medicine at Mount Sinai

George Niedt

Icahn School of Medicine at Mount Sinai

Cooperative Institutions

Wake Forest University

179

John Wiley & Sons (United States)

155

Oxfam

121

Hudson Institute

121

John Wiley & Sons (United Kingdom)

116

Atrium Health Wake Forest Baptist

The University of Texas MD Anderson Cancer Center

Massachusetts General Hospital

Harvard University

Memorial Sloan Kettering Cancer Center

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Progressive Hyperpigmentation on the Face in a Skin of Color Woman: Answer

American Journal of Dermatopathology (2024)

Marianne E. Gosch Amy McMichael Angela G. Niehaus Omar P. Sangüeza

Skin Color

10.1097/dad.0000000000002671

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Citations (0)

DNA Determination in Dysplastic Nevi A Comparative Study Between Flow Cytometry and Image Analysis

American Journal of Dermatopathology (1993)

Omar P. Sangüeza Dan M. Hyder Antony C. Bakke Clifton R. White

Dysplastic nevi (DN), described in 1978, have been associated with increased risk of melanoma, but the role of DN as precursors of melanoma is still controversial. Recent studies have shown that DN are very common in the general population, bringing into question this purported association. Numerous investigations have attempted to correlate the presence of DN in individuals with specific phenotypic and genotypic features, including the presence of abnormal DNA content. Because the occurrence of such abnormal DNA stemlines in neoplasms may be associated with malignant behavior, we studied 38 biopsies from 19 patients that histologically fulfilled criteria for DN in order to ascertain characteristics of DNA content. Nuclear suspensions made from paraffin-embedded tissue were evaluated by both flow cytometry and image analysis techniques. All cases demonstrated diploid populations by both DNA measurement methods. Our results contradict previous reports of aneuploid populations in these melanocytic lesions.

Cytometry

Nuclear DNA

10.1097/00000372-199304000-00001

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Citations (17)

Malignant Sweat Gland Tumors

Hematology/Oncology Clinics of North America (2018)

Christine Ahn Omar P. Sangüeza

Adenoid Cystic Carcinoma

Apocrine

Cylindroma

Dermatopathology

Cribriform

10.1016/j.hoc.2018.09.002

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Citations (43)

Neuromuscular ultrasound for taxane peripheral neuropathy in breast cancer

Muscle & Nerve (2020)

Thomas Lycan Fang‐Chi Hsu Christine Ahn Alexandra Thomas Francis O. Walker

Abstract Background Our study aim was to evaluate neuromuscular ultrasound (NMUS) for the assessment of taxane chemotherapy‐induced peripheral neuropathy (CIPN), the dose‐limiting toxicity of this agent. Methods This cross‐sectional study of breast cancer patients with taxane CIPN measured nerve cross‐sectional area (CSA) by NMUS and compared with healthy historical controls. Correlations were determined between CSA and symptom scale, nerve conduction studies, and intraepidermal nerve fiber density (IENFD). Results A total of 20 participants reported moderate CIPN symptoms at a median of 3.8 months following the last taxane dose. Sural nerve CSA was 1.2 mm 2 smaller than healthy controls ( P ≤ .01). Older age and time since taxane were associated with smaller sural nerve CSA. For each 1 mm 2 decrease in sural nerve CSA, distal IENFD decreased by 2.1 nerve/mm (R 2 0.30; P = .04). Conclusions These data support a sensory predominant taxane neuropathy or neuronopathy and warrant future research on longitudinal NMUS assessment of CIPN.

Taxane

Chemotherapy-Induced Peripheral Neuropathy

Sural nerve

Nerve conduction study

10.1002/mus.26833

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Citations (18)

PEComas: a review with emphasis on cutaneous lesions

Seminars in Diagnostic Pathology (2009)

Sarah N. Walsh Omar P. Sangüeza

Angiomyolipoma

Perivascular Epithelioid Cell

Desmin

10.1053/j.semdp.2009.09.002

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Citations (50)

Rhinophyma's fibrous variant. Histopathology and immunohistochemistry.

PubMed (1994)

Whitney D. Tope Omar P. Sangüeza

Rhinophyma may present with either of two distinct histopathologic appearances. The most common shows histopathologic features of rosacea. The second pattern shows telangiectasia, diffuse dermal fibrosis with abundant mucin, and a virtual absence of pilosebaceous structures. These histopathologic features of the lesser-known fibrous variant of rhinophyma mimic those of fibrous papule of the nose. We report an unusual case that histopathologically resembled the second variant. Immunohistochemically, the dermal fibroblasts in this case showed intense staining with Factor XIIIa in a pattern similar to that demonstrated in fibrous papules. S-100 protein failed to stain these dermal fibroblasts. The presence of Factor XIIIa+ dermal fibroblasts may portend the evolution of fibrosis in rosacea and other inflammatory dermatoses.

Rhinophyma

Factor XIIIa

Histopathology

Dermal papillae

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Citations (26)

Malignant Neoplasms

Humana Press eBooks (2003)

Omar P. Sangüeza Luis Requena

10.1385/1-59259-360-7:217

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Citations (2)

Pathology of Vascular Skin Lesions: Clinicopathologic Correlations

Luís Requena Omar P. Sangüeza

Companion CD-ROM Embryology, Anatomy, and Histology of the Vasculature of the Skin Embryologic Aspects Anatomic and Histologic Aspects of the Dermis and Blood Vessels Special Techniques for the Study of Vessels and Vascular Proliferations Immunohistochemical Stains Molecular Techniques Cytogenetic Studies Classification of Cutaneous Vascular Proliferations Cutaneous Vascular Hamartomas Phakomatosis Pigmentovascularis Eccrine Angiomatous Hamartoma Cutaneous Vascular Malformations Nevus Anemicus Cutis Marmorata Telangiectatica Congenita Nevus Flammeus Hyperkeratotic Vascular Stains Venous Malformations Superficial Cutaneous Lymphatic Malformations Cystic Lymphatic Malformations (Cystic Hygromas) Lymphangiomatosis Cutaneous Lesions Characterized by Dilation of Preexisting Vessels Spider Angioma (Nevus Araneus) Capillary Aneurysm-Venous Lake Telangiectases Angiokeratomas Lymphangiectases Cutaneous Vascular Hyperplasias Angiolymphoid Hyperplasia with Eosinophilia Pyogenic Granuloma Bacillary Angiomatosis Verruga Peruana Intravascular Papillary Endothelial Hyperplasia (Masson's Pseudo-Angiosarcoma) Pseudo-Kaposi's Sarcoma Reactive Angioendotheliomatosis Benign Neoplasms Angioma Serpiginosum Infantile Hemangiomas Cherry Angiomas (Senile Angiomas) Arteriovenous Hemangioma Hobnail Hemangioma (Targetoid Hemosiderotic Hemangioma) Microvenular Hemangioma Tufted Angioma Glomeruloid Hemangioma Acquired Elastotic Hemangioma Kaposiform Hemangioendothelioma Sinusoidal Hemangioma Giant Cell Angioblastoma Spindle Cell Hemangioma (Formerly Spindle Cell Hemangioendothelioma Benign Lymphangioendothelioma Benign Vascular Proliferations in Irradiated Skin Glomus Tumors Hemangiopericytoma Cutaneous Myofibroma Malignant Neoplasms Kaposi's Sarcoma Epithelioid Hemangioendothelioma Endovascular Papillary Angioendothelioma (Dabska's Tumor or Papillary Intralymphatic Angioendothelioma) Retiform Hemangioendothelioma Composite Hemangioendothelioma Cutaneous Angiosarcoma of the Face and Scalp of Elderly Patients (Wilson Jones' Angiosarcoma) Cutaneous Angiosarcoma Associated with Lymphedema Radiation-Induced Cutaneous Angiosarcoma Epithelioid Angiosarcoma Malignant Glomus Tumor (Glomangiosarcoma) Other Cutaneous Neoplasms With Significant Vascular Component Multinucleate Cell Angiohistiocytoma Angiofibroma Angioleiomyoma Angiolipoma Cutaneous Angiolipoleiomyoma Cutaneous Angiomyxoma Aggressive Angiomyxoma Disorders Erroneously Considered as Vascular Neoplasms Kimura's Disease 'Malignant' Angioendotheliomatosis (Intravascular Lymphomatosis) Acral Pseudolymphomatous Angiokeratoma in Children (APACHE) Index

Epithelioid Hemangioendothelioma

Hemangioendothelioma

Angioma

Glomus tumor

Angiomatosis

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Concurrent Metastatic Merkel Cell Carcinoma and Cutaneous Squamous Cell Carcinoma in the Same Lymph Node

American Journal of Dermatopathology (2018)

Lubna Suaiti Oluwakemi Onajin Omar P. Sangüeza

The coexistence of Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC) in the same cutaneous lesion is well known. The pathogenesis is believed to be distinct from conventional polyomavirus-related MCC, and it has a more aggressive course. Metastasis of MCC and SCC to the same lymph node is exceedingly rare with only one previously reported case in the English literature. To the best of our knowledge, this is the second case of MCC and SCC with metastasis to the same lymph node. Our case demonstrates the aggressive nature of the combined MCC and SCC in the setting of immunosuppression.

Merkel cell polyomavirus

Immunosuppression

Merkel cell

10.1097/dad.0000000000001318

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Citations (5)

Classification of Cutaneous Vascular Proliferations

Humana Press eBooks (2003)

Omar P. Sangüeza Luís Requena

10.1385/1-59259-360-7:15

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Citations (1)