A study was made of the medical records of 102 patients hospitalized because of postmenopausal bleeding. Diagnostic procedures used included vaginal examination, Papanicolaou smears, curettage and cervical biopsy. The major associated pathological conditions (possibly etiological factors) in the series were chronic cervicitis, fibromyoma of the uterus, endometrial polyps, cervical polyps and adenomyosis of the uterus. Sclerosis of the uterine vessels was suggested as another possible cause of this type of bleeding. Neither the amount and type of bleeding nor the pattern of associated symptoms were of diagnostic value.A history of hormonal therapy prior to the onset of bleeding is not sufficient evidence to establish that as the cause of the bleeding and the patient should be as completely investigated as if this history were not present. In over 61 per cent of cases in this series, uterine curettage with or without cervical biopsy, cauterization, conization or trachelorrhaphy, was the only treatment required for both diagnosis and therapy.
HE iNciDENcE of the various types of testicu-T lar tumors, both spontaneous and experimentally produced, varies considerably from species to species.I n man teratoid tumors of germinal origin comprise 98 per cent of all testicular growths, and interstitial-cell tumors and androblastomas'G make up the remaining 2 per cent.In the dog, on the other hand, fully two thirds of the tumors are of the interstitialcell type or tubular adenomas.9T h e remaining third are germinomas or einbryonal carcinomas that do not show teratoid differentiation.In rodents teratoid growths are encountered only rarely, while interstitial-cell tumors are common and can easily be produced experimentally.8Spontaneous teratoid growths appear both in horses17 and in roosters,12 and the rooster has proved a useful animal for the experimental production of teratomas.About twenty-five years ago h!lichalowsky reported that he had produced teratomas by injecting the testes of roosters with zinc chloride during January, February, and March, while injections of tar, petroleum, acetic acid, sodium chloride, and distilled water failed to result in such growths.Three of sixty-two birds that had bilateral injections showed five teratomas.His work was confirmed by Baggl and by Falin.Bagg reported that he had induced tumors in seasons other than spring by using gonadotropic hormones in addition to zinc.Although Michalowsky stated that crushing and cutting of testicular tissue failed to produce the growths he had evoked with zinc, Champy and Lavedan reported the production of "embryoinas" in partially castrated birds.Since work on the teratoid tumors of man has
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