Asoke Banerji

Amrita Vishwa Vidyapeetham

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Govind P. Kalena

Bhabha Atomic Research Centre

Chinchu Bose

Amrita Vishwa Vidyapeetham

Sanjay Talukdar

Bhabha Atomic Research Centre

Sandip K. Nayak

Bhabha Atomic Research Centre

Pandurangan Nanjan

Amrita Vishwa Vidyapeetham

JΝ

J. Ν. Mathur

Bhabha Atomic Research Centre

Devanand L. Luthria

Beltsville Human Nutrition Research Center

Gajanan J. Chintalwar

Bhabha Atomic Research Centre

M. S. Murali

Newcastle University

Bipin G. Nair

Amrita Vishwa Vidyapeetham

Cooperative Institutions

Bhabha Atomic Research Centre

Amrita Vishwa Vidyapeetham

University of Calcutta

Amrita Institute of Medical Sciences and Research Centre

Rajiv Gandhi Centre for Biotechnology

Indian Institute of Technology Kharagpur

Lawrence Berkeley National Laboratory

Bhabha Atomic Research Center Hospital

Scripps Research Institute

Homi Bhabha National Institute

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Bioprospection of Kerala flora for Phytoecdysoids : Value addition to biodiversity

C M Sreejit Chinchu Bose Pandurangan Nanjan P Thomas Mathew Asoke Banerji

Flora

Value (mathematics)

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Value addition to unutilized Indian plants & plant products

Pandurangan Nanjan Chinchu Bose Walter Schrenk Asoke Banerji

Value (mathematics)

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Seabuckthron (Hippophae rhamnoides L.) leaf extract ameliorates the gamma radiation mediated DNA damage and hepatic alterations.

PubMed (2014)

Amitava Khan Krishnendu Manna Chinchubose Dipesh Das Mahuya Sinha

In vitro assessment showed that H. rhamnoides (HrLE) extract possessed free radical scavenging activities and can protect gamma (gamma) radiation induced supercoiled DNA damage. For in vivo study, Swiss albino mice were administered with HrLE (30 mg/kg body weight) for 15 consecutive days before exposing them to a single dose of 5 Gy of beta radiation. HrLE significantly prevented the radiation induced genomic DNA damage indicated as a significant reduction in the comet parameters. The lipid peroxidation, liver function enzymes, expression of phosphorylated NFkappaB (p65) and IkappaBalpha increased whereas the endogenous antioxidants diminished upon radiation exposure compared to control. Pretreatment of HrLE extract ameliorated these changes. Based on the present results it can be concluded that H. rhamnoides possess a potential preventive element in planned and accidental nuclear exposures.

Hippophae rhamnoides

Comet Assay

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Citations (16)

Occurrence of 7,4’-dimethyltectorigenin in the flowers of the Dalbergia sissoo

Current Science (1965)

Asoke Banerji V. V. Sreerama Murti TR Seshadri

Dalbergia sissoo

Dalbergia

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Indian medicinal plant, Coscinium fenestratum-a new bio source for the multifunctional bio active molecule-ecdysterone.

International Journal of Herbal Medicine (2015)

Sreejit Chittiyath Madhavan Chinchu Bose Thomas Mathew Perakathusseril Asoke Banerji

Phytochemical investigation on Coscinium fenestratum (Gaertn.) Collebr, an important Ayurvedic plant, revealed the presence of significant amounts of ecdysterone in the stem (0.22%) and leaves (0.12%), in addition to berberine. Ecdysterone was characterized using High Performance Liquid Chromatography (HPLC), Infrared Spectroscopy (FT-IR) and Liquid Chromatography-Mass Spectroscopy (LC-MS). Isolation of this multifunctional bioactive compound will throw light on the chemical basis for the various pharmacological effects of Coscinium plant extract.

Phytochemical

Ecdysterone

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Citations (6)

Insect growth regulatory activity of naturally occurring quinones and their derivatives in Dysdercus koenigii Fabr. (Hem., Pyrrhocoridae)

Journal of Applied Entomology (2001)

Smita Banerjee S. Magdum G. P. Kalena Asoke Banerji

10.1046/j.1439-0418.2001.00489.x

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Citations (9)

Bioassay-Guided Isolation and Evaluation of Antiproliferative Effects of (Z)-Ethylidene-4, 6-Dimethoxycoumaran-3-One from Pogostemon Quadrifolius (Benth.)

PubMed (2017)

Sanith Cheriyamundath Rahul Raghavan Asoke Banerji Karel D. Klika Cornelia M. Ulrich

The aim of the study was to isolate and identify the major cytotoxic principle from plant leaves of Pogostemon quadrifolius (Benth.) and evaluate its antiproliferative potential against human cancer cells. Plant leaves were extracted sequentially with a soxhlet apparatus, using petroleum ether, chloroform and methanol solvents. Petroleum ether and chloroform extracts exhibited antiproliferative properties against Caco-2, HeLa, THP-1, MCF-7 and Jurkat E6-1cancer cell lines tested, but methanol extracts failed to exhibit such activity. The major antiproliferative principle from petroleum ether and chloroform extracts was isolated with the help of bioassay guided column chromatography. This cytotoxic compound was further analysed by UV, TLC, HPLC, LC-MS, GC-MS and NMR analyses and was identified to be novel: (Z)-ethylidene-4,6-dimethoxycoumaran-3-one (Compound 1). The half-maximal inhibitory concentrations for proliferation (IC50) exhibited by compound 1 were 19.4, 23.1, 22.1, 35.9 and 8.32 μM against Caco-2, HeLa, THP-1, MCF-7 and Jurkat E6-1 cancer cell lines, respectively. Further experiments revealed that compound 1 triggered the apoptosis mode of cell death in cancer cell lines. Thus, the present study allowed isolation and identification of a novel cytotoxic natural compound, (Z)-ethylidene-4,6-dimethoxycoumaran-3-one, from plant leaves of P. quadrifolius (Benth.). Our pre-clinical study also indicated that compound 1 is particularly active in the acute T cell leukemia cell line (Jurkat E6-1) with potential for application as a chemotherapeutic agent in the future.

HeLa

Jurkat cells

Petroleum ether

10.22034/apjcp.2017.18.7.1783

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Citations (2)

Biotechnology Letters (1998)

Neeta A. Salvi Sanninje R. Udupa Asoke Banerji

Rhizopus arrhizus

Enantiomeric excess

Rhizopus

10.1023/a:1005301229609

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Citations (13)

Antimicrobial activity of plumbagin, a naturally occurring naphthoquinone from Plumbago rosea, against Staphylococcus aureus and Candida albicans

International Journal of Medical Microbiology (2016)

Sweatha V. Nair Gaurav Baranwal Maitrayee Chatterjee Arun Sachu Anil Vasudevan

Plumbagin

10.1016/j.ijmm.2016.05.004

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Citations (99)

ChemInform Abstract: Synthesis of Dimethyl Ethers of Atalantoflavone, Carpachromene and Their Analogues.

ChemInform (1990)

Asoke Banerji Devanand L. Luthria

Abstract Since atalantoflavone dimethyl ether (IIIb) possesses a significant insecticidal activity, it was of interest to synthesize analogues for the evaluation of their bioactivity.

10.1002/chin.199021308

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