Shogo Kimura

Hokkaido University

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A global multicenter study on reference values: 2. Exploration of sources of variation across the countries

Clinica Chimica Acta (2016)

Kiyoshi Ichihara Yeşim Özarda Julian H. Barth George G. Klee Yoshihisa Shimizu

The intent of this study, based on a global multicenter study of reference values (RVs) for serum analytes was to explore biological sources of variation (SVs) of the RVs among 12 countries around the world. As described in the first part of this paper, RVs of 50 major serum analytes from 13,396 healthy individuals living in 12 countries were obtained. Analyzed in this study were 23 clinical chemistry analytes and 8 analytes measured by immunoturbidimetry. Multiple regression analysis was performed for each gender, country by country, analyte by analyte, by setting four major SVs (age, BMI, and levels of drinking and smoking) as a fixed set of explanatory variables. For analytes with skewed distributions, log-transformation was applied. The association of each source of variation with RVs was expressed as the partial correlation coefficient (rp). Obvious gender and age-related changes in the RVs were observed in many analytes, almost consistently between countries. Compilation of age-related variations of RVs after adjusting for between-country differences revealed peculiar patterns specific to each analyte. Judged from the rp, BMI related changes were observed for many nutritional and inflammatory markers in almost all countries. However, the slope of linear regression of BMI vs. RV differed greatly among countries for some analytes. Alcohol and smoking-related changes were observed less conspicuously in a limited number of analytes. The features of sex, age, alcohol, and smoking-related changes in RVs of the analytes were largely comparable worldwide. The finding of differences in BMI-related changes among countries in some analytes is quite relevant to understanding ethnic differences in susceptibility to nutritionally related diseases.

Variation (astronomy)

10.1016/j.cca.2016.09.015

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Citations (48)

Recognizing uterine torsion as a differential diagnosis in pregnant cats with severe anemia to provide appropriate and timely care in the absence of a definitive presurgical diagnosis.

PubMed (2024)

Shogo Kimura WeiChun Huang Elroy V Williams Kevin C Cosford

A pregnant female domestic longhair cat ~8 mo of age was referred to the Western College of Veterinary Medicine (Saskatoon, Saskatchewan) for a diagnostic evaluation of severe anemia (PCV: 10.8%) after a 2-day period of lethargy. A CBC, serum biochemistry profile, FeLV/FIV testing, and abdominal radiographs were completed and did not determine a cause for the anemia. Abdominal ultrasonography identified 1 viable and 6 nonviable and fetuses, anechoic fluid in the uterus, and a mild volume of peritoneal effusion. A whole-blood transfusion and C-section with ovariohysterectomy were performed even though a definitive presurgical diagnosis for the anemia had not yet been established. Exploratory surgery revealed a left uterine horn torsion with a necrotic base, severe congestion, and 7 nonviable fetuses. Following surgery, the queen made a full clinical recovery. Key clinical message: Uterine torsion can be easily overlooked as a cause of severe anemia due to the relative infrequency of this condition in cats and the low sensitivity of ultrasonography to provide a definitive presurgical diagnosis. Client communication must emphasize the need for a prompt surgical intervention to establish the diagnosis and to save the cat, despite poor rates of neonatal survival. Once the animal is stabilized after surgery, further diagnostic tests and procedures are indicated if the cause of anemia has not yet been identified.

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Prediction of Instability in Rotating Shaft System with Casing by Operational Modal Analysis

Mechanisms and machine science (2023)

Daiki Goto Tsuyoshi INOUE Shogo Kimura Akira Heya Shinsaku Nakamura

Rotordynamics

Operational Modal Analysis

10.1007/978-3-031-45705-0_84

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Influence of the magnitude of the taper angle of divergent and convergent tapered annular seals on the stability of a vertical rotor-seal system

Journal of vibration and acoustics (2024)

Shogo Kimura Tsuyoshi INOUE Hiroo TAURA Akira Heya

Abstract The rotordynamic (RD) fluid force generated in seals affects the stability of turbomachinery. RD coefficients have been determined using bulk-flow or computational fluid dynamics analyses, and the effect of seals on the stability has been evaluated. Plain annular seals and convergent tapered annular seals have been used to improve stability, and their dynamic characteristics have been studied. On the other hand, research has also been conducted on divergent tapered annular seals, because the seals can become divergent tapered due to operating conditions, pressure deformation, and manufacturing error. These studies do not provide a comprehensive picture of the effect of divergent tapered annular seals on stability, because some show that divergent tapered annular seals reduce stability, whereas others show that they may increase stability. This study analyses a plain liquid annular seal, divergent tapered annular seals, and convergent tapered annular seals to clarify the effect of the taper angle on the stability of a vertical rotor-seal system. The analysis was carried out by continuously changing the taper angle for both the divergent tapered and convergent tapered annular seals, the RD coefficients were calculated in each case, and the onset speed of instability (OSI) was calculated by eigenvalue analysis. The change in OSI, or stability, with a change in taper angle is then investigated. The change in OSI with a change in taper angle was investigated experimentally and compared with the analytical results to demonstrate the validity of the analytical results. The analytical and experimental results were in qualitative and quantitative agreement.

10.1115/1.4066873

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A Case of Vaginal Endometriosis with Excessive Bleeding

Sanfujinka no shimpo (1957)

S Matsuura Shogo Kimura

Vaginal bleeding

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Modeling of Journal Bearings for Wear Diagnosis and Its Verification Using SVM

PHM Society Asia-Pacific Conference (2023)

Masaki Goto Tsuyoshi INOUE Akira Heya Keiichi Katayama Shogo Kimura

Recently, deterioration of infrastructure facilities has become problem. To reduce inspection costs, wear diagnosis of journal bearings in operating conditions using machine learning has been studied. However, constructing a highly accurate machine learning model requires training data, and it may be difficult to conduct numerous tests depending on the application. In this study, a mathematical model of a rotor system for wear diagnosis of journal bearings was developed, and the vibration data was obtained when the clearance changed due to wear. Then, changes in the features used for condition monitoring were examined. Furthermore, the important features for wear diagnosis were selected and SVM models were constructed to verify the mathematical model.

10.36001/phmap.2023.v4i1.3640

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Objective evaluation of caudal deviation of the nasal septum and selection of the appropriate septoplasty technique

Auris Nasus Larynx (2021)

Shogo Kimura Masanobu Suzuki Aya Honma Akira Nakazono Masayuki Osawa

Deviated nasal septum

10.1016/j.anl.2021.04.012

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Citations (2)

Prognostic factor of nivolumab for advanced gastric cancer patients with poor performance status patients.

Journal of Clinical Oncology (2020)

Toshihiko Matsumoto Ukyo Okazaki Yusuke Kurioka Shogo Kimura Takao Tsuzuki

391 Background: Nivolumab has changed the treatment of advanced gastric cancer (AGC). Nivolumab shows better outcome compared to best supportive care in AGC patients who received at least two prior regimen. Although there is not reliable date of poor performance status(PS) AGC patients who received nivolumab. We investigated efficacy and safety of nivolumab for AGC patients with poor PS. Methods: We retrospectively collected clinicopathologic data from patients with AGC who received nivolumab monotherapy in Himeji Red Cross Hospital from October 2017 to June 2019. Results: 49 AGC patients who received nivolumab were analyzed. 27 patients were PS 0 or 1(Good Group), and 22 patients were PS 2 or 3(Poor Group). Median progression free survival and overall survival was 61 days and 180 days in Good Group and 36 days and 85 days in Poor Group. Overall survival (OS) was significantly shorter in Poor group(180 days vs 85 days, p = 0.0255). Disease control rate was 23% in Good group and 9% in Poor group. 33% patients were experienced immune related adverse event (iRAE) in Good Group, and 18% in Poor Group. We investigated prognostic factor of OS in Poor Group such as Royal Marsden Hospital Score(RMH score), modified Glasgow prognostic score(mGPS), and Japan Clinical Oncology Group (JCOG) prognostic index. RMH score and JCOG prognostic index good or moderate group was significantly longer overall survival than poor group (93 days vs 35 days (p = 0.0214)). JCOG prognostic index was most correlated with OS among these tools. Conclusions: This study suggested that nivolumab has a modest effect and is feasible as third line or later line for AGC patients. JCOG prognostic index was suggested to be effective in predicting prognosis in AGC patients who received nivolumab.

Performance status

Regimen

10.1200/jco.2020.38.4_suppl.391

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Effects of the once- versus twice-monthly administration of epoetin beta pegol on ferrokinetics, including hepcidin-25 levels, in patients undergoing hemodialysis

Nihon Toseki Igakkai Zasshi (2016)

Shogo Kimura Yuka Soga Yuki Kato Makoto Mizutani Naohisa Tomosugi

Continuous erythropoietin receptor activator (CERA) 月1回投与から月2回投与に変更することで鉄動態の変動を検討した. CERA月1回投与中の24例を, 月1回投与継続群 (A群12例) と月2回投与変更群 (B群12例) に分けて, ヘプシジン25, Fe, TSAT, フェチリン, Hb, 目標Hb値維持率, ERI (erythropoiesis-stimulating agent resistance index), CERA投与量の推移を12か月間比較検討した. 開始時, 両群間で性別, 年齢, 原疾患, Hb, フェリチン, CERA投与量に差はなかった. ヘプシジン25は1週時では両群ともに有意な減少 (p<0.05) を示し, 1・3・12か月時においてはB群で有意に低値 (p<0.05) であった. Fe, TSAT, フェリチンも同様であった. ERIはA群で0.4％上昇したのに対して, B群で10.4％低下した. CERA投与量もB群で改善傾向にあった. 鉄動態の変動を考慮し, 投与法で鉄代謝に与える影響の違いを認めた. CERA月2回投与は鉄の利用効率を高めneocytolysisを防止し, 骨髄造血を促進する投与法の可能性が示唆された.

10.4009/jsdt.49.827

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Effects of CV-11974 on renal haemodynamics and renal function in dogs.

PubMed (1994)

Hongbin He Toshiaki Tamaki Atsufumi Tomohiro Toshihiro Kita Yasuharu Aki

The effects of CV-11974, a nonpeptide angiotensin II (Ang II) receptor antagonist, on renal haemodynamics and function were examined in pentobarbital-anaesthetised dogs to evaluate the physiological role of endogenous Ang II in regulating renal haemodynamics and urine formation. Intrarenal infusion of CV-11974 (1 microgram/kg/min) increased renal blood flow (RBF), glomerular filtration rate (GFR), urine flow, and urinary electrolyte excretion (Na and K), with no change in mean arterial pressure (MAP). In another group of dogs, intrarenal infusion of CV-11974 (1 microgram/kg/min) increased the fractional excretion of sodium, the fractional proximal excretion of sodium, and the fractional distal excretion of sodium. CV-11974 did not affect the linear relationship between the free water reabsorption rate (TCH2O) and osmolar clearance (Cosm). These results suggest that endogenous Ang II may play an important role in regulating renal haemodynamics and stimulating sodium reabsorption. Our data indicates that endogenous Ang II may stimulate sodium reabsorption at the proximal and the distal portions of the tubule, with the exception of the medullary portion of the ascending limb of Henle.

Renal sodium reabsorption

Free water clearance

Renal physiology

Filtration fraction

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Citations (1)