Neifi Hassan Saloum Deghaide

Universidade Federal do Rio Grande do Norte

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Eduardo Antônio Donadi

Universidade de São Paulo

Celso Teixeira Mendes‐Junior

Universidade de São Paulo

Erick C. Castelli

Universidade Estadual Paulista (Unesp)

Maria de Lourdes Veronese Rodrigues

Collaborative Research Group

Philippe Moreau

Centre National de la Recherche Scientifique

Adriano Martinelli

University of Pisa

Ana Cláudia Teixeira

Universidade de São Paulo

Roberto Oliveira Dantas

Universidade de São Paulo

Fernanda Fernandes Souza

Universidade Federal do Espírito Santo

Maria José Franco Brochado

King's College Hospital NHS Foundation Trust

Cooperative Institutions

Universidade de São Paulo

Universidade de Ribeirão Preto

Clinics Hospital of Ribeirão Preto

Universidade Brasil

Fundação Oswaldo Cruz

Fundação Faculdade de Medicina

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade Federal de Pernambuco

Universidade Federal do Rio Grande do Norte

Universidade Federal de São Paulo

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HLA class I and II alleles in brazilian ameridians from the upper amazon basin

Tissue Antigens (2002)

Eduardo Antônio Donadi Maria de Lourdes Veronese Rodrigues José Fernando de Castro Figueiredo Neifi Hassan Saloum Deghaide M. A. J. S. Vas

Amazon basin

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Citations (0)

Variabilidade do gene HLA-E na população brasileira

Luciana C. Veiga‐Castelli Erick C. Castelli Neifi Hassan Saloum Deghaide Wilson A. Silva Philippe Moreau

Source

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Citations (0)

Association of HLA-G 3′ untranslated region variants with type 1 diabetes mellitus

Human Immunology (2016)

Rafael Sales de Albuquerque Celso Teixeira Mendes‐Junior Norma Lucena‐Silva Camila Leal Lopes da Silva Diane Meire Rassi

Linkage Disequilibrium

HLA-DQB1

HLA-G

Genetic Association

10.1016/j.humimm.2016.02.001

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Citations (22)

HLA Class I Profile in Patients with AIDS and Toxoplasma gondii Chorioretinitis

M. Veronese Rodrigues Ana Lúcia G. Demarco Eduardo Antônio Donadi Luís A. Demarco Neifi Hassan Saloum Deghaide

Chorioretinitis

Toxoplasmosis

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Citations (4)

Esophageal motility of patients with different grades of esophageal involvement by Chagas' disease

Gastroenterology (1998)

Roberto Oliveira Dantas Neifi Hassan Saloum Deghaide Eduardo Antônio Donadi

Chagas Disease

Esophageal motility disorder

10.1016/s0016-5085(98)83032-1

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Citations (1)

Interleukin‐18 and interferon‐gamma polymorphisms are implicated on proviral load and susceptibility to human T‐lymphotropic virus type 1 infection

Tissue Antigens (2012)

Maurício Cristiano Rocha–Junior Rodrigo Haddad Daiani Cristina Cilião Alves Virgínia Mara de Deus Wagatsuma Celso Teixeira Mendes‐Junior

Interleukin‐18 (IL‐18) and interferon‐gamma (IFN‐γ) exert important functions in both innate and adaptive immune responses against intracellular pathogens and viruses. Previous studies suggested that host genetic factors, including cytokines gene polymorphisms, could be involved in the pathogenesis of human T‐cell leukemia virus type 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). Thus, we analyzed −137C/G and −607A/C of the IL‐18 promoter and +874T/A of the IFN‐γ in DNA samples from 98 HTLV‐1‐infected individuals exhibiting or not clinical symptoms and 150 healthy control individuals. The IL‐18 promoter −607CC genotype was significantly lower in HTLV‐1 asymptomatic carriers (HAC) and HTLV‐1‐infected individuals (HAC + HAM/TSP) than healthy control group. In contrast, the −607AC genotype was significantly higher in HAC and HTLV‐1‐infected individuals group compared to the healthy control group. The −137G/−607A IL‐18 haplotype was higher in infected group than healthy control group, and the −137C/−607C IL‐18 haplotype was increased in the healthy control group compared to the others. Finally, the IFN‐γ polymorphism analysis showed that the HTLV‐1‐infected individuals with +874AT genotype presented higher proviral load than +874AA genotype. These data indicate that the IL‐18 −607AC genotype and −137G/−607A haplotype could be a risk factor for HTLV‐1 infection, whereas the protective effect could be conferred by −607CC genotype and −137C/−607C haplotype. Also, the IFN‐γ could be implicated on the proviral load levels.

Tropical spastic paraparesis

Pathogenesis

10.1111/j.1399-0039.2012.01887.x

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Citations (19)

600 THE 14BP-DELETION POLYMORPHISM IN HLA-G GENE CONFERS SUSCEPTIBILITY TO THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA (HCC) IN BRAZILIAN POPULATION

Journal of Hepatology (2010)

Ana Cláudia Teixeira Erick C. Castelli Fernanda Fernandes Souza C. Cantñao Sarah Rebeca Dantas Ferreira

10.1016/s0168-8278(10)60602-2

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Citations (1)

Data on HLA class I/II profile in Brazilian pemphigus patients

Data in Brief (2016)

Maria José Franco Brochado Daniela Francisca Nascimento Neifi Hassan Saloum Deghaide Eduardo Antônio Donadi Ana Maria Ferreira Roselino

Pemphigus are blistering autoimmune diseases related with genetic and environmental factors. Here we describe HLA genotyping in pemphigus patients. First, we review the HLA class I/II data on pemphigus reported in Brazilian samples and then present the HLA class I (-A, -B, -C) and class II (-DRB1, -DQA1, -DQB1) alleles related to susceptibility/resistance to pemphigus by comparing 86 patients with pemphigus foliaceus, 83 patients with pemphigus vulgaris, and 1592 controls from the northeastern region of the state of São Paulo, Southeastern Brazil. The data presented here are related to the manuscript "Differential HLA class I and class II associations in Pemphigus Foliaceus and Pemphigus Vulgaris patients from a prevalent Southeastern Brazilian region" Brochado et al. (2016) [1].

Pemphigus foliaceus

Pemphigus vulgaris

10.1016/j.dib.2016.05.077

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Citations (12)

Association of interleukin-18 (IL-18), tumor necrosis factor-'alfa' (TNF-'alfa') and interferon-'gama' (IFN-'gama) genes polymorphisms with severity of liver fibrosis in brazilian patients with chronic hepatitis B

Journal of Hepatology (2010)

Suzete C. Ferreira Silvana Gama Florêncio Chachá Fernanda Fernandes Souza Ana Cláudia Teixeira Neifi Hassan Saloum Deghaide

Interferon alfa

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A majority of Brazilian patients with rheumatoid arthritis HLA-DRB1 alleles carry both the HLA-DRB1 shared epitope and anti-citrunillated peptide antibodies

Brazilian Journal of Medical and Biological Research (2008)

Paulo Louzada‐Júnior Marta Freitas Renê D. Oliveira Neifi Hassan Saloum Deghaide Roseneide Aparecida Conde

The objective of the present study was to evaluate the contribution of the shared epitope (SE), the rheumatoid arthritis (RA) protection model, and the occurrence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in RA patients from a genetically diverse population. One hundred and forty Brazilian RA patients and 161 matched controls were typed for HLA-DRB1 alleles using amplified DNA hybridized with sequence-specific oligonucleotide probes or primers. Patients were stratified according to the presence or absence of SE (DRB1*0401, *0404, *0405, *0101, *1001, and *1402), of the DERAA alleles (DRB1*0103, *0402, *1102, *1103, *1301, *1302, and *1304), and X (all other alleles). Anti-CCP antibodies were measured by ELISA. The combined frequency of SE-positive alleles was significantly greater (76.4 vs 23.6%, P < 0.0001) than the controls. The SE/SE and SE/X genotypes were over-represented (P < 0.0001, OR = 6.02) and DERAA/X was under-represented in RA patients (P < 0.001, OR = 0.49), whereas the frequencies of the SE/DERAA, X/X and X/DERAA genotypes were not significantly different from controls. The frequency of anti-CCP antibodies was higher in SE-positive patients than in SE-negative patients (64.6 vs 44.7%, P = 0.03; OR = 2.25). Although the Brazilian population is highly miscegenated, the results of this study support the findings observed in most genetically homogeneous populations with RA; however, they are not mutually exclusive but rather complementary. The participation of DRB1-DERAA alleles in protection against RA was also observed (OR = 0.4; 95%CI = 0.23-0.68).

HLA-DRB1

Immunogenetics

10.1590/s0100-879x2008005000021

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Citations (35)