Hong Zhu

The People's Hospital Tongling

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Xiaoqin Zeng

Shanghai Jiao Tong University

Xiaodong Sun

Shanghai First People's Hospital

Jianbo Wu

Southwest Medical University

Zhenming Xu

Nanjing University of Aeronautics and Astronautics

Tao Deng

Shanghai Jiao Tong University

Rampi Ramprasad

Georgia Institute of Technology

Chengyi Song

Shanghai Jiao Tong University

Shihong Wu

Yantai Nanshan University

Peng Tao

Shanghai Jiao Tong University

Wen Shang

Shanghai Jiao Tong University

Cooperative Institutions

Shanghai Jiao Tong University

522

Chinese Academy of Sciences

277

Fudan University

172

Chinese Academy of Medical Sciences & Peking Union Medical College

167

Sun Yat-sen University

167

Zhejiang University

125

Central South University

124

Capital Medical University

118

University of Chinese Academy of Sciences

114

Sichuan University

109

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Novel gene mutation in von Hippel-Lindau disease – a report of two cases

BMC Medical Genetics (2019)

Ruizhong Wang Wenjie Cao Zhaoxia Wang Hong Zhu

Abstract Background Von Hippel-Lindau (VHL) syndrome is a familial autosomal dominant hereditary neoplastic disease caused by mutations in the VHL gene. Approximately 503 kinds of VHL gene mutations have been reported. Different types of mutations manifest various clinical phenotypes, from benign to malignant tumours or coexisting cysts. Thus, a gene mutation test is essential in the diagnosis of VHL syndrome. Case presentation We reported two cases in which a novel mutation site in the c530-536delGACTGGA region in exon 3 of the VHL gene resulted in the development of VHL syndrome. According to the ACMG guidelines, this variation is pathogenic and consistent with autosomal dominant inheritance. This variation has not been reported anywhere in the databases or literature. Conclusion This report will add a new mutation site to VHL gene databases. The newly added gene mutation and its associated clinical phenotypes will help improve the accuracy of VHL diagnosis and benefit the community of VHL gene mutation carriers.

Human genetics

Von Hippel–Lindau disease

10.1186/s12881-019-0930-8

Cite

Citations (7)

Additional file 1 of YWHAH, a member of 14-3-3 family proteins, and PSME2, the proteasome activator subunit 2, are key host factors of Japanese encephalitis virus infection

Figshare (2023)

Chaoyue Liu Yanhong Yang Qianqian Li Weimin Hu Jinxia Chang

Additional file 1.

10.6084/m9.figshare.23658357

Cite

Citations (0)

Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs

Biochemical and Biophysical Research Communications (2018)

Yiji Feng Jian Liang Yuanqi Zhai Junran Sun Jing Wang

Proinflammatory cytokine

Sirtuin 1

SIRT2

10.1016/j.bbrc.2018.01.159

Cite

Citations (16)

CD73-Adenosine A1R Axis Regulates the Activation and Apoptosis of Hepatic Stellate Cells Through the PLC-IP3-Ca2+/DAG-PKC Signaling Pathway

Frontiers in Pharmacology (2022)

Zhenni Liu Xue Wu Qi Wang Zixuan Li Xueqi Liu

Alcohol-related liver fibrosis (ALF) is a form of alcohol-related liver disease (ALD) that generally occurs in response to heavy long-term drinking. Ecto-5′-nucleotidase (NT5E), also known as CD73, is a cytomembrane protein linked to the cell membrane via a GPI anchor that regulates the conversion of extracellular ATP to adenosine. Adenosine and its receptors are important regulators of the cellular response. Previous studies showed that CD73 and adenosine A1 receptor (A 1 R) were important in alcohol-related liver disease, however the exact mechanism is unclear. The aim of this study was to elucidate the role and mechanism of the CD73-A 1 R axis in both a murine model of alcohol and carbon tetrachloride (CCl 4 ) induced ALF and in an in vitro model of fibrosis induced by acetaldehyde. The degree of liver injury was determined by measuring serum AST and ALT levels, H & E staining, and Masson’s trichrome staining. The expression levels of fibrosis indicators and PLC-IP 3 -Ca 2+ /DAG-PKC signaling pathway were detected by quantitative real-time PCR, western blotting, ELISA, and calcium assay. Hepatic stellate cell (HSC) apoptosis was detected using the Annexin V-FITC/PI cell apoptosis detection kit. Knockdown of CD73 significantly attenuated the accumulation of α-SMA and COL1a1 damaged the histological architecture of the mouse liver induced by alcohol and CCl 4 . In vitro , CD73 inhibition attenuated acetaldehyde-induced fibrosis and downregulated A 1 R expression in HSC-T6 cells. Inhibition of CD73/A 1 R downregulated the expression of the PLC-IP 3 -Ca 2+ /DAG-PKC signaling pathway. In addition, silencing of CD73/A 1 R promoted apoptosis in HSC-T6 cells. In conclusion, the CD73-A 1 R axis can regulate the activation and apoptosis of HSCs through the PLC-IP 3 -Ca 2+ /DAG-PKC signaling pathway.

Hepatic stellate cell

10.3389/fphar.2022.922885

Cite

Citations (7)

SNHG16/miR-216-5p/ZEB1 signal pathway contributes to the tumorigenesis of cervical cancer cells

Archives of Biochemistry and Biophysics (2017)

Hong Zhu Yan Zeng Chenchen Zhou Weiping Ye

Competing Endogenous RNA

Small nucleolar RNA

10.1016/j.abb.2017.11.003

Cite

Citations (98)

18F-Alfatide II for the evaluation of axillary lymph nodes in breast cancer patients: comparison with 18F-FDG

European Journal of Nuclear Medicine and Molecular Imaging (2022)

Jiang Wu Jihong Tian Yiyan Zhang Hengshan Ji Jingjing Sun

Axillary lymph nodes

Standardized uptake value

10.1007/s00259-021-05333-z

Cite

Citations (10)

A Rational Design of Garnet-Type Li7la3zr2o12 with Ultrahigh Moisture Stability

SSRN Electronic Journal (2022)

Hongpeng Zheng Guoyao Li Jiqiong Liu Shaoping Wu Xingmin Zhang

Lithium-stuffed garnets, one of the most promising solid electrolytes for all-solid-state lithium batteries (ASSLBs), are typically vulnerable to water or moisture. In this work, Li 6.5 La 3 Zr 1.5 Ta 0.5 O 12 (LLZT) with ionic conductivity of 7.36 ×10 −4 S cm -1 at room temperature and ultrahigh moisture stability is designed and synthesized by a solvent-free route with no excess lithium source. After storing in ambient atmosphere for four months, the LLZT maintains an ionic conductivity of 6.41 ×10 −4 S cm −1 . With optimized lithium contents, the LLZT is stored in an atmosphere rich in H 2 O and CO 2 at 65 °C for 24 hours and the ionic conductivity only decreases by 6.9% to 6.6 ×10 −4 S cm −1 . Even undergone water-immersion, the LLZT pellet shows good electrochemical stability, which allows an interfacial resistance of 14.6 Ω cm 2 with Li and stable cycling performance of Li|LLZT|LFP cell, exhibiting a high capacity retention of 93% after 100 cycles. Several important features including high relative density, few grain boundaries, water-stable secondary phase of La 2 Zr 2 O 7 , and the Li + -deficient garnet lattice are combined to contribute to the moisture stability as suggested by morphology and surface chemistry analysis and first-principles calculations. This study provides valuable insights into synthesizing fast and moisture-stable lithium garnets in a time-efficient way, which is vital for developing garnet-based ASSLBs.

Rational design

10.2139/ssrn.4037335

Cite

Citations (0)

Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.

PubMed (1996)

Hong Zhu Robert J. Melder Laurence T. Baxter Rohit Jain

The goal of the present investigation was to develop a physiologically based kinetic model to describe the biodistribution of immunologically active effector cells in normal and neoplastic tissues of mammals based on the current understanding of lymphocyte trafficking pathways and signals. The model was used to extrapolate biodistribution among different animal species and to identify differences among different effector populations and between intra-arterial and systemic injections. Most importantly, the model was used to discern critical parameters for improving the delivery of effector cells. In the model, the mammalian body was divided into 12 organ compartments, interconnected in anatomic fashion. Each compartment was characterized by blood flow rate, organ volume and lymphatic flow rate, and other physiological and immunological parameters. The resulting set of 45 differential equations was solved numerically. The model was used to simulate the following biodistribution data: (a) nonactivated T lymphocytes in rats; (b) interleukin 2-activated tumor-infiltrating lymphocytes in humans; (c) nonactivated natural killer (NK) cells in rats; and (d) interleukin 2-activated adherent NK cells in mice. Comparisons between simulations and data demonstrated the feasibility of the model and the scaling scheme. The similarities as well as differences in biodistribution of different lymphocyte populations were revealed as results of their trafficking properties. The importance of lymphocyte infiltration from surrounding normal tissues into tumor tissue was found to depend on lymphocyte migration rate, tumor size, and host organ. The study confirmed that treatment with effector cells has not been as impressive as originally promised, due, in part, to the biodistribution problems. The model simulations demonstrated that low effector concentrations in the systemic circulation greatly limited their delivery to tumor. This was due to high retention in normal tissues, especially in the lung. Reducing normal tissue retention through decreasing attachment rate or adhesion site density in the lung by 50% could increase the tumor uptake by approximately 40% for tumor-infiltrating lymphocytes and by approximately 60% for adherent NK cells. Our analysis suggested the following strategies to improve effector cell delivery to tumor: (a) bypassing the initial lung entrapment with administration to the arterial supply of tumor; (b) reducing normal tissue retention using effector cells with high deformability or blocking lymphocyte adhesion to normal vessels; and (c) enhancing tumor-specific capture and arrest by modifying the tumor microenvironment.

Biodistribution

Adoptive Cell Transfer

Source

Cite

Citations (86)

Intrinsic Lithiophilicity of Li–Garnet Electrolytes Enabling High‐Rate Lithium Cycling

Advanced Functional Materials (2019)

Hongpeng Zheng Shaoping Wu Ran Tian Zhenming Xu Hong Zhu

Abstract Solid‐state lithium batteries are widely considered as next‐generation lithium‐ion battery technology due to the potential advantages in safety and performance. Among the various solid electrolyte materials, Li–garnet electrolytes are promising due to their high ionic conductivity and good chemical and electrochemical stabilities. However, the high electrode/electrolyte interfacial impedance is one of the major challenges. Moreover, short circuiting caused by lithium dendrite formation is reported when using Li–garnet electrolytes. Here, it is demonstrated that Li–garnet electrolytes wet well with lithium metal by removing the intrinsic impurity layer on the surface of the lithium metal. The Li/garnet interfacial impedance is determined to be 6.95 Ω cm 2 at room temperature. Lithium symmetric cells based on the Li–garnet electrolytes are cycled at room temperature for 950 h and current density as high as 13.3 mA cm −2 without showing signs of short circuiting. Experimental and computational results reveal that it is the surface oxide layer on the lithium metal together with the garnet surface that majorly determines the Li/garnet interfacial property. These findings suggest that removing the superficial impurity layer on the lithium metal can enhance the wettability, which may impact the manufacturing process of future high energy density garnet‐based solid‐state lithium batteries.

Lithium metal

Fast ion conductor

10.1002/adfm.201906189

Cite

Citations (138)

ANALYSIS AND COMPARISON OF FLEXURE STRUCTURES USED IN 3-D ELECTROSTATIC MICROACTUATORS FOR HARD DISK DRIVES

International Journal of Computational Engineering Science (2003)

Bangtao Chen Jianmin Miao Hong Zhu

Microactuator

Precision engineering

10.1142/s1465876303000958

Cite

Citations (0)