S Plaeger-Marshall

University of California, Los Angeles

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E. Richard Stiehm

Ronald Reagan UCLA Medical Center

E. Richard Stiehm

University of California, Los Angeles

Bonnie J. Ank

University of California, Los Angeles

Janis V. Giorgi

University of Padua

Albert Haas

University of Bonn

Terry Chin

Nanyang Technological University

Loran T. Clement

University of South Alabama

Jerry W. Smith

Indiana University Bloomington

L. A. Wilson

Nottingham University Hospitals NHS Trust

Valentin Isacescu

VA San Diego Healthcare System

Cooperative Institutions

University of California, Los Angeles

UCLA Medical Center

UCLA Health

UCLA Jonsson Comprehensive Cancer Center

Harbor–UCLA Medical Center

University of Southern California

University of Colorado Denver

University of California System

Long Beach Memorial Medical Center

Johns Hopkins University

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Replication of Herpes Simplex Virus in Blood Monocytes and Placental Macrophages from Human Neonates

Pediatric Research (1989)

S Plaeger-Marshall Bonnie J. Ank Karl M. Altenburger Lewis I. Pizer Richard B. Johnston

Permissiveness

Cord blood

Monocyte

10.1203/00006450-198908000-00014

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Citations (12)

T Cell Activation in Pediatric AIDS Pathogenesis: Three-Color Immunophenotyping

Clinical Immunology and Immunopathology (1994)

S Plaeger-Marshall Valentin Isacescu Sheryl O'Rourke Jeanne Bertolli Yvonne J. Bryson

Immunophenotyping

Pathogenesis

10.1006/clin.1994.1046

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Citations (72)

A statistical method for assessing change in immunologic parameters in a patient

Journal of Clinical Immunology (1986)

Jeremy M. G. Taylor S Plaeger-Marshall J. L. Fahey

10.1007/bf00918705

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Citations (5)

Lymphocyte function in major depression

Acta Psychiatrica Scandinavica (1989)

Lori L. Altshuler S Plaeger-Marshall Steven H. Richeimer Molly S. Daniels L.R. Baxter

Immunoiogic function as measured by lymphocyte response to phytohemagglutinin (PHA) mitogen was evaluated in 8 psychiatric inpatients. All were less than 45 years of age and had a DSM-1II diagnosis of major depression. When patient's immunoiogic responses were compared with healthy age- and sex-matched controls, a significant increase in PHA mitogen stimulation was observed in the depressed group. Further, a significantly greater variance in PHA response was observed in (he patients compared with controls. The literature on depression and immunity is reviewed and the clinical implications of our findings are discussed.

Depression

10.1111/j.1600-0447.1989.tb01314.x

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Citations (48)

Preparation of CD8bright and CD8dim lymphocyte populations using two positive selection methods in tandem

Journal of Immunological Methods (1993)

Harry E. Prince Saul Bermudez S Plaeger-Marshall

10.1016/0022-1759(93)90339-9

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Citations (11)

Permissiveness of rabbit monocytes and macrophages for herpes simplex virus type 1

Infection and Immunity (1982)

S Plaeger-Marshall L. A. Wilson Jerry W. Smith

The permissiveness of rabbit monocytes and macrophages for herpes simplex virus was examined. Peripheral blood monocytes, alveolar macrophages, and peritoneal exudate macrophages were studied for their ability to replicate herpes simplex virus strains RE and KOS. Results indicated different degrees of interaction with virus depending on the macrophage type. Only peritoneal exudate macrophages showed evidence of virus replication. Productive infection was limited, with only a small number of cells (0.02%) yielding infectious virus. Higher numbers of cells appeared to be abortively infected. Approximately 40% expressed antigens, whereas virtually all were killed by exposure to virus. Coreless particles were seen by electron microscopy in about one-third. Alveolar macrophages were also killed by virus and showed evidence of virus adsorption, but showed no indication of productive or abortive infection. Monocytes neither adsorbed nor replicated virus, and viability was unaffected. Results suggest that differences in degrees of cellular maturation or differentiation, or both, account for the spectrum of interactions seen between herpes simplex virus and rabbit macrophages.

Permissiveness

10.1128/iai.35.1.151-156.1982

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Citations (19)

Bare lymphocyte syndrome. Consequences of absent class II major histocompatibility antigen expression for B lymphocyte differentiation and function.

Journal of Clinical Investigation (1988)

Loran T. Clement S Plaeger-Marshall Albert Haas Andrew Saxon A. M. Martin

The bare lymphocyte syndrome is a rare combined immunodeficiency disorder associated with the absence of class I and/or class II major histocompatibility (MHC) antigens. Although it has been inferred that the immune deficiency is a consequence of disordered MHC-restricted interactions among otherwise normal cells, the biological capabilities and differentiation of B lymphocytes deficient in class II MHC antigens have not been rigorously analyzed. We have examined the phenotypic and functional attributes of B cells with absent class II MHC antigens. Our data demonstrate that these B cells are intrinsically defective in their responses to membrane-mediated activation stimuli. In addition, virtually all the B cells had phenotypic evidence of arrested differentiation at an immature stage. Finally, these B cells also failed to express the C3d-EBV receptor normally present on all B lymphocytes. These data indicate that class II MHC molecules are vital participants in early events of the B cell activation cascade, and that other non-MHC membrane molecules may also be absent as a consequence of either arrested differentiation or as a result of the basic defect affecting the expression of MHC membrane antigens.

MHC restriction

CD1

10.1172/jci113371

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Citations (22)

Experimental Infection of Subpopulations of Human Peripheral Blood Leukocytes by Herpes Simplex Virus

Experimental Biology and Medicine (1978)

S Plaeger-Marshall John W. Smith

Results from examination of peripheral blood leukocytes from five subjects, three with antibody to HSV and two without, showed that HSV type 1 may replicate in mitogen-stimulated T and B lymphocytes and in continuous lymphoblastoid cell lines derived from either B or T cells. Significant replication was also noted in monocytes from each subject but not in polymorphonuclear leukocyte subpopulations. Replication in monocytes was found to be dependent on certain conditions of culture and viral inoculation. Only adherent cells cultured for 72-hr prior to infection produced significant yields of virus.

Simplexvirus

Monocyte

10.3181/00379727-158-40185

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Citations (25)

Alterations in cytotoxic and phenotypic subsets of natural killer cells in acquired immune deficiency syndrome (AIDS)

Journal of Clinical Immunology (1987)

S Plaeger-Marshall Celsa A. Spina Janis V. Giorgi Ronald T. Mitsuyasu Peter Wolfe

CD16

10.1007/bf00915420

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Citations (101)