Н. П. Евстигнеева

Research Field

Cite

Citations (0)

CERVICAL MUCUS NEUTROPHILS FUNCTIONAL STATUS INTERACTION WITH THE SPECIES COMPOSITION OF VAGINAL LACTOBACILLI IN PREGNANT WOMEN

Journal of microbiology epidemiology immunobiology (2018)

Yu. S. Shishkova В. Ф. Долгушина E. D. Grafova S. A. Zavyalova И.В. Курносенко

Aim. Of the study is to assess cervical mucus neutrophils functional status depend on dominant lactobacillus strain in I trimester of pregnancy women. Material and methods. We definded 40 lactobacillus strains obtained from the genital tract of the pregnant women. We used mass spectrometry analysis to identify vaginal lactobacilli and evaluated biofilm formation. Also, we studied cervical mucus neutrophils viability, lysosomal activity, spontaneous and induced NBT test (Nitroblue Tetrazolium test), ability to absorb the latex particles. Isolated strains were divided into 3 groups depending on presence or absence of vaginal or cervical channel infectious diseases. Results. We identified 5 lactobacilli types: L. jensenii, L. mspatus, L. аcidophilus, L. gasseri, L. delbrueckii among 40 definded strains. We determined different intensity of phagocytosis depending on dominant strain in normocenosis. With the L. crispatus prevalence demonstrated the least intensity of phagocytosis compared with L. acidophilus and L.jensenii. Lactobacilli able to intensively produce biomatrix in condition of genital infection. Thus blocking antigenic potential and result in absence of NBT-reducing power of neutrophilic granulocytes and reduction antimicrobial protection of pregnant women genital tract mucosa. Conclusion. The indicators of neutrophils functional status depend on dominant lactobacilli strain in I trimester of pregnancy women.

Lactobacillus crispatus

Genital tract

Lactobacillus gasseri

10.36233/0372-9311-2018-4-51-56

Cite

Citations (4)

CCDC 1901179: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Константин В. Щербаков Mariya A. Artemyeva Yanina V. Burgart Н. П. Евстигнеева Н. А. Герасимова

10.5517/ccdc.csd.cc21tbcl

Cite

Citations (0)

Synthesis and Antibacterial and Antifungal Activity of 3-(Azol-1-Yl)-6-R-1,2,4,5-Tetrazines

Pharmaceutical Chemistry Journal (2020)

Р.И. Ишметова Н. А. Герасимова Н. П. Евстигнеева I.A. Belyaninova N.K. Ignatenko

10.1007/s11094-020-02097-y

Cite

Citations (4)

Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs

Russian Chemical Bulletin (2022)

Svetlana O. Kushch Marina V. Goryaeva Ya.V. Burgart Галина А. Триандафилова K. O. Malysheva

10.1007/s11172-022-3579-y

Cite

Citations (8)

Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity

Beilstein Journal of Organic Chemistry (2022)

А.V. Korotina S.G. Tolshchina Р.И. Ишметова Н. П. Евстигнеева Н. А. Герасимова

A series of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines has been synthesized through oxidation reaction of the corresponding 3,6-disubstituted 1,2,4,5-tetrazines bearing amidine fragments. It is shown that the heterocyclic systems obtained can be modified easily at C(3) position in the reactions with aliphatic alcohols and amines. Also, the reactivity of [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines towards CH-active compounds has been studied. The obtained triazolo[1,5-b]annulated 1,2,4,5-tetrazines proved to be active in micromolar concentrations in vitro against filamentous anthropophilic and zooanthropophilic dermatophyte fungi (Trichophyton, Microsporum and Epidermofiton), which cause skin and its appendages (hair, nails) diseases.

Reactivity

Dermatophyte

Amidine

10.3762/bjoc.18.29

Cite

Citations (3)

CCDC 1940910: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Irina V. Shchur Evgeny V. Shchegolkov Ya.V. Burgart Alisa N. Kozitsina Anna V. Ivanova

10.5517/ccdc.csd.cc234p0z

Cite

Citations (0)

CCDC 1587557: Experimental Crystal Structure Determination

The Cambridge Structural Database (2018)

Egor V. Verbitskiy Svetlana A. Baskakova Н. А. Герасимова Н. П. Евстигнеева Н. В. Зильберберг

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1q8zjh

Cite

Citations (0)

CCDC 2175996: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

О. Г. Худина Natalia А. Elkina Yanina V. Burgart Марина А. Ежикова М. И. Кодесс

10.5517/ccdc.csd.cc2c19f5

Cite

Citations (0)

Synthesis of mycostatics based on 4-aryldiazenyl-3,5-dimethylpyrazoles

Russian Chemical Bulletin (2021)

О. Г. Худина А. Е. Иванова Ya.V. Burgart Н. А. Герасимова Н. П. Евстигнеева