Teresa Zalewska

Polish Academy of Sciences

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Małgorzata Ziemka‐Nałęcz

Mossakowski Medical Research Institute, Polish Academy of Sciences

Krystyna Domańska‐Janik

Polish Academy of Sciences

Joanna Sypecka

Mossakowski Medical Research Institute, Polish Academy of Sciences

Luiza Stanaszek

Mossakowski Medical Research Institute, Polish Academy of Sciences

Victor J. Hruby

University of Arizona

Joanna Jaworska

Procter & Gamble (Belgium)

Henry I. Yamamura

University of Arizona

H Zajac

Polish Academy of Sciences

Peg Davis

University of Arizona

Barbara Zabłocka

Mossakowski Medical Research Institute, Polish Academy of Sciences

Cooperative Institutions

Polish Academy of Sciences

Mossakowski Medical Research Institute, Polish Academy of Sciences

University of Arizona

Medical University of Warsaw

Jagiellonian University

Centre National de la Recherche Scientifique

Laboratory of Molecular Genetics

Łukasiewicz Research Network - Industrial Chemistry Institute

Banner - University Medical Center Tucson

University of Warsaw

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Effect of matrix metalloproteinases inhibition on the proliferation and differentiation of HUCB-NSCs cultured in the presence of adhesive substrates

Acta Neurobiologiae Experimentalis (2010)

Szymczak Patrycja Luiza Stanaszek Joanna Sypecka Sokołowska Anna Teresa Zalewska

Cell adhesion to extracellular matrix (ECM) generates intracellular signals that modulate cell survival, proliferation, migration and differentiation. Because of its heterogeneous nature, ECM has the potential to induce unique responses that are composition-dependent. One approach to study the effect of ECM signals on cell development, independently on signals from other extracellular sources, has been to deprive cells of serum and to analyze the influence of specific ligands. In the current work we determine the potential of different ECM proteins (fibronectin, laminin, collagen) on the proliferation and differentiation of human umbilical cord blood-derived neural stem cells (HUCB-NSCs) cultured in serum-free conditions. The effect of tested ECM components on the above processes might be associated with the particular pattern of their proteolysis. In this context enzymes that are responsible for the modification of ECM proteins are of particular pertinence. Matrix metalloproteinases (MMPs) represent a family of enzymes known to play role in the modification of ECM and by this can change the cell-ECM substrate interaction, required for cell development. In an effort to elucidate the participation of MMPs in the proliferation and differentiation HUCB-NSCs were cultured in the presence or absence of MMPs inhibitors - GM6001 and doxycycline. Our results show that addition of the above inhibitors interfered with both the proliferation and differentiation of progenitor cells toward the neuronal lineage. This effect depends on the adhesive ECM substrate and is most pronounced in the presence of fibronectin and laminin. In conclusion, our results suggest that MMPs modulate interaction between HUCB-NSCs and their environment and therefore might be an important component in neurogenesis-associated processes.

10.55782/ane-2010-1805

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Citations (25)

Sex Differences in Brain Disorders

International Journal of Molecular Sciences (2023)

Małgorzata Ziemka‐Nałęcz Paulina Pawelec Karolina Ziąbska Teresa Zalewska

A remarkable feature of the brain is its sexual dimorphism. Sexual dimorphism in brain structure and function is associated with clinical implications documented previously in healthy individuals but also in those who suffer from various brain disorders. Sex-based differences concerning some features such as the risk, prevalence, age of onset, and symptomatology have been confirmed in a range of neurological and neuropsychiatric diseases. The mechanisms responsible for the establishment of sex-based differences between men and women are not fully understood. The present paper provides up-to-date data on sex-related dissimilarities observed in brain disorders and highlights the most relevant features that differ between males and females. The topic is very important as the recognition of disparities between the sexes might allow for the identification of therapeutic targets and pharmacological approaches for intractable neurological and neuropsychiatric disorders.

Sexual dimorphism

Sex characteristics

Brain Function

10.3390/ijms241914571

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Citations (14)

Para‐Substituted phenylalanine‐4 analogues of [l‐Ala³]. DPDPE: highly selective δ opioid receptor ligands

Journal of Peptide Research (1997)

Ronald C. Haaseth Teresa Zalewska Peg Davis Henry I. Yamamura Frank Porreca

Several para‐substituted Phe 4 analogues of the δ 1 ‐selective antagonist [ l ‐Ala 3 ]. DPDPE (DPADPE) were prepared and evaluated for their brain‐binding and in vitro pharmacological effects. Unlike the p ‐haloPhe 4 analogues of DPDPE and the deltorphins, similar analogues of DPADPE with electron‐withdrawing groups substituted at the para‐position of the Phe 4 aromatic ring did not all have increased potency and selectivity for δ opioid receptors, but all retained high potency and selectivity for δ opioid receptors greater than DPDPE. © Munksgaard 1997.

Structure–activity relationship

10.1111/j.1399-3011.1997.tb01182.x

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Citations (6)

Copper content in brains with blood-brain barrier damaged by freezing, hemorrhage and encephalomalacia (experimental work).

PubMed (1966)

H Wiśniewski M Śmiałek Teresa Zalewska H Szydłowska Rap Zm

Encephalomalacia

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Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia

Biomolecules (2022)

Teresa Zalewska Paulina Pawelec Karolina Ziąbska Małgorzata Ziemka‐Nałęcz

Epidemiological studies and clinical observations show evidence of sexual dimorphism in brain responses to several neurological conditions. It is suggested that sex-related differences between men and women may have profound effects on disease susceptibility, pathophysiology, and progression. Sexual differences of the brain are achieved through the complex interplay of several factors contributing to this phenomenon, such as sex hormones, as well as genetic and epigenetic differences. Despite recent advances, the precise link between these factors and brain disorders is incompletely understood. This review aims to briefly outline the most relevant aspects that differ between men and women in ischemia and neurodegenerative disorders (AD, PD, HD, ALS, and SM). Recognition of disparities between both sexes could aid the development of individual approaches to ameliorate or slow the progression of intractable disorders.

Sexual dimorphism

Sex characteristics

10.3390/biom13010026

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Citations (12)

Transient forebrain ischemia modulates focal adhesion kinase (FAK)‐mediated signal transduction in gerbil hippocampus

Journal of Neurochemistry (2003)

Małgorzata Ziemka‐Nałęcz Anna Sarnowska Teresa Zalewska

Focal adhesion kinase (FAK) is thought to play a major role in conveying survival signals from extracellular matrix (ECM). Phosphorylated FAK may interact with other nonreceptor kinases such as Src, and adaptor molecule Cas, perhaps providing a pathway by which ECM may regulate cell viability. In the present study the expression and tyrosine phosphorylation of FAK, Src and Cas after 5 min of global ischemia were investigated. The primary activation/phosphorylation of FAK, observed during first 6 h after ischemic injury, was followed by its profound down‐regulation. At 72 h of reperfusion the level of phosphorylated FAK decrease to about 50% of the control. The decrease of FAK phosphorylation coincides with its proteolytic degradation. Cleavage of FAK coincided temporally with the loss of Src and Cas. Ischemia‐induced proteolytic processing of the investigated proteins may lead to the interruption of ECM‐derived signals and compromise neuronal survival. Acknowledgements: Sponsored by SCSR 4P05A 08619 and Med. Res. Ctr.

Paxillin

PTK2

Gerbil

10.1046/j.1471-4159.85.s2.22_6.x

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Citations (0)

Quantitative topography of copper in Wilson's disease and in porto-systemic encephalopathy.

PubMed (1967)

H Wiśniewski M Śmiałek H Szydłowska Teresa Zalewska

Wilson's disease

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