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Eric Musasizi

Infectious Diseases Research Collaboration

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Melissa D. Conrad

University of California, San Francisco

Sara Lynn Blanken

Radboud University Medical Center

Jordache Ramjith

Radboud University Medical Center

Joseph Okoth

Infectious Diseases Research Collaboration

Ismail Onyige

Infectious Diseases Research Collaboration

John Rek

Infectious Diseases Research Collaboration

Sarah G. Staedke

Liverpool School of Tropical Medicine

Daniel Ayo

Infectious Diseases Research Collaboration

Emmanuel Arinaitwe

Infectious Diseases Research Collaboration

Chris Drakeley

London School of Hygiene & Tropical Medicine

Cooperative Institutions

Makerere University

Radboud University Nijmegen

Infectious Diseases Research Collaboration

University of California, San Francisco

Radboud University Medical Center

London School of Hygiene & Tropical Medicine

San Francisco General Hospital

Radboud Institute for Molecular Life Sciences

Liverpool School of Tropical Medicine

University Medical Center

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Susceptibility of Anopheles gambiae to Natural Plasmodium falciparum Infection: A Comparison between the Well-Established Anopheles gambiae s.s Line and a Newly Established Ugandan Anopheles gambiae s.s. Line

American Journal of Tropical Medicine and Hygiene (2023)

Daniel Ayo Ismail Onyige Joseph Okoth Eric Musasizi Ambrose Oruni

Much of our understanding of malaria transmission comes from mosquito feeding assays using Anopheles mosquitoes from colonies that are well adapted to membrane feeding. This raises the question whether results from colony mosquitoes lead to overestimates of outcomes in wild Anopheles mosquitoes. We successfully established an Anopheles colony using progeny of wild Anopheles gambiae s.s. mosquitoes (Busia mosquitoes) and directly compared their susceptibility to infection with Plasmodium falciparum with the widely used An. gambiae s.s. mosquitoes (Kisumu mosquitoes) using gametocyte-infected Ugandan donor blood. The proportion of infectious feeds did not differ between Busia (71.8%, 23/32) and Kisumu (68.8%, 22/32, P = 1.00) mosquitoes. When correcting for random effects of donor blood, we observed a 23% higher proportion of infected Busia mosquitoes than infected Kisumu mosquitoes (RR, 1.23; 95% CI, 1.10-1.38, P < 0.001). This study suggests that feeding assays with Kisumu mosquitoes do not overestimate outcomes in wild An. gambiae s.s. mosquitoes, the mosquito species most relevant to malaria transmission in Uganda.

Anopheles gambiae

10.4269/ajtmh.23-0203

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Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda

The Journal of Infectious Diseases (2022)

John Rek Sara Lynn Blanken Joseph Okoth Daniel Ayo Ismail Onyige

Abstract Achieving malaria elimination requires a better understanding of the transmissibility of human infections in different transmission settings. This study aimed to characterize the human infectious reservoir in a high endemicity setting in eastern Uganda, using gametocyte quantification and mosquito feeding assays. In asymptomatic infections, gametocyte densities were positively associated with the proportion of infected mosquitoes (β = 1.60; 95% CI, 1.32–1.92; P < .0001). Combining transmissibility and abundance in the population, symptomatic and asymptomatic infections were estimated to contribute to 5.3% and 94.7% of the infectious reservoir, respectively. School-aged children (5–15 years old) contributed to 50.4% of transmission events and were important drivers of malaria transmission.

Transmissibility (structural dynamics)

10.1093/infdis/jiac169

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Citations (26)