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Raheleh Rafaiee

Mazandaran University of Medical Sciences

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Hamed Ghazvini

Mazandaran University of Medical Sciences

Seyedeh Masoumeh Seyedhosseini Tamijani

Mazandaran University of Medical Sciences

Fahimeh Mohseni

Shahroud University of Medical Sciences

Mohammad Niroumand Sarvandani

Shahroud University of Medical Sciences

Alireza Bakhshipour

Zahedan University of Medical Sciences

Hamid Kalalian Moghaddam

Shahroud University of Medical Sciences

Seyed Hamzeh Hosseini

Mazandaran University of Medical Sciences

Behzad Garmabi

Shahroud University of Medical Sciences

Masoud Asadi

Arak University

Naghmeh Ahmadiankia

Shahroud University of Medical Sciences

Cooperative Institutions

Mazandaran University of Medical Sciences

Shahroud University of Medical Sciences

Tehran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Kerman University of Medical Sciences

University of Tehran

Iran University of Medical Sciences

Zahedan University of Medical Sciences

Mashhad University of Medical Sciences

Shiraz University of Medical Sciences

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Status of Immunity Against the Hepatitis A Virus in Healthy Population: A Report from Southeastern Iran

Archives of Clinical Infectious Diseases (2021)

Alireza Bakhshipour Narjes Sargolzaie Raheleh Rafaiee

Background: Recently, epidemiological studies on hepatitis A virus (HAV) infection showed the seroprevalence has been changing due to changes in lifestyle. To the best of our knowledge, there have been no published data on the seropositivity of HAV in Zahedan, southeastern Iran. Objectives: This study aimed to investigate the seroprevalence of HAV immunoglobulin G (IgG) antibody in Zahedan, southeastern Iran, to provide the required information for better planning in preventive strategies. Methods: In this cross-sectional study, using the available sampling method, a total of 250 serum samples (18 years and above) in both the urban and rural areas of Zahedan were evaluated for anti-HAV IgG by enzyme-linked immunosorbent assay. Results: Based on the results, it was observed that 228 out of 250 (91.2%) serum samples were positive for HAV IgG antibody. Male gender, family size, parents’ education, mother’s occupation, and history of jaundice before the age of 12 years were associated with positive HAV antibody (P < 0.001). The seroprevalence HAV rates were not statistically different between the residents of urban and rural regions. Conclusions: The seropositivity of HAV is high in both the urban and rural areas of Zahedan, Iran. Therefore, the HAV vaccination of the general population is not necessary. It is recommended to monitor HAV seroprevalence in the general population to determine high-risk groups, including anti-HAV seronegative individuals, for HAV vaccination in the residents of the southeast border.

Seroprevalence

10.5812/archcid.118869

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Citations (1)

Basic research on circadian disruption using animal and human organoid models: a review

Biological Rhythm Research (2025)

Hamideh Rahmati Behzad Garmabi Hamed Ghazvini Seyedeh Masoumeh Seyedhosseini Tamijani Seyedeh Maryam Mousavi-Bourkheili

Organoid

Chronobiology

10.1080/09291016.2025.2459689

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Letter to the Editor

Journal of Applied Animal Ethics Research (2024)

Fahimeh Mohseni Raheleh Rafaiee

10.1163/25889567-bja10053

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Hepatitis B Virus Infection in Vaccinated Children and Adolescents with HBsAg-positive Parents: Is Routine Vaccination Sufficient?

Health Scope (2022)

Alireza Bakhshipour Manijeh Khalili Raheleh Rafaiee

Background: Hepatitis B virus (HBV) is a severe public health problem in Iran. This study was conducted to investigate the intrafamilial transmission of HBV in vaccinated children whose one or both parents were positive for hepatitis B surface antigen (HBsAg). Methods: In a study with retrospective cohort design, 110 exposed cases with HBsAg-positive parent(s) were compared with 110 unexposed controls of the same sex and age groups. The participants were directly asked about demographic characteristics, medical history, and vaccinations. Blood samples were collected and analyzed for HBV infection markers using the ELIZA method. Results: Overall, 1.8% HBsAg (P = 0.15) and 13.6% hepatitis B core antibody (HBcAb) (P < 0.0001) positivity rates were detected in the exposed group. The hepatitis B surface antibody titer (HBsAb) showed that 34.5% of cases and 56.3% of controls had HBsAb levels > 10 IU/L. There was a significant difference in the protective HBsAb level between the two groups (P < 0.0001). There were significant associations between HBsAb level and gender in the exposed group and decreased HBsAb levels and age. Conclusions: The high rate of positive HBcAb and HBsAg and decreasing HBsAb levels with age in this study indicate that routine childhood vaccination programs are inadequate in preventing HBV transmission and vaccine routes changing or further booster vaccination is essential. Effective case finding in vaccinated children with HBsAg-positive parents, intradermal vaccination, and hepatitis B immunoglobulin in newborns with HBsAg-positive fathers are suggested.

Hepatitis B

10.5812/jhealthscope.120505

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The Effects of Transcranial ‎Direct Current Stimulation Over the Dorsolateral Prefrontal Cortex ‎on Cognitive Dysfunction in Alzheimer’s Disease: A Narrative Review

Journal of Kermanshah University of Medical Sciences (2023)

Fatemeh Rahimi Shourmasti Mehdi Khodamoradi Seyedeh Masoumeh Seyedhosseini Tamijani Raheleh Rafaiee Carlos Augusto Carvalho de Vasconcelos

Context: Patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) are more likely to suffer from cognitive dysfunction due to dementia. Transcranial direct current stimulation (tDCS) as a non-invasive treatment strategy has been used as an efficient strategy to improve cognitive function. Evidence Acquisition: Several studies investigating tDCS over the dorsolateral prefrontal cortex (dlPFC) were reviewed. Results: Most of these studies have targeted the left dlPFC, indicating that tDCS over the dlPFC can improve cognitive function, such as memory, visual recognition, attention, decision-making, and cognitive decline. However, there are still many unanswered questions about the effect of tDCS over the dlPFC on the connectivity of this brain region as a key node for cognitive function. Meanwhile, further research should be conducted to elucidate the effects of tDCS over the dlPFC on brain connectivity and AD biomarkers. In addition, more investigations should be conducted to identify the exact mechanisms affecting dlPFC stimulation on cognitive dysfunction in AD patients. Conclusions: Based on the results, tDCS over the DlPFC could improve cognitive function in AD patients.

Transcranial Direct Current Stimulation

Dorsolateral prefrontal cortex

Brain stimulation

Cognitive Decline

10.5812/jkums-136442

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Three-Month Mortality and Related Risk Factors in Delirium Patients: A Prospective Cohort Study

Shiraz E-Medical Journal (2020)

Payam Mehrabani Seyed Davood Hosseini Raheleh Rafaiee Seyed Hamzeh Hosseini

Background: Delirium is a common problem in elderly patients. Recently, therapists have shifted their attention away from treatment towards prevention; therefore, investigation of related risk factors is essential in these patients. Methods: In this prospective cohort study, newly admitted elderly patients, with a Glasgow Coma Scale score above 10, were screened and enrolled. The patients were evaluated for delirium using the Neecham Confusion Scale (NCS). The risk factors included four major domains: patient characteristics (age, gender, and substance abuse), chronic diseases, acute diseases, and blood biochemical factors. Results: A total of 100 patients were assessed for delirium. The mean age of the participants was 79.9 ± 15.1 years (24% female). The proportion of in-hospital deaths was 12%, with a cumulative three-month mortality of 40%. The rate of delirium development was significantly associated with underlying factors, including cancer, hypertension, cerebrovascular accident, cirrhosis, dementia, and substance abuse. The laboratory results showed a blood urea nitrogen (BUN) level ≥ 50 mg/dL in 33% of patients with delirium. There was a significant association between BUN level and NSC score (P < 0.05). Among other laboratory variables, higher erythrocyte sedimentation rate and C-reactive protein level were significantly associated with delirium. Moreover, Kaplan-Meier survival curves for effective factors, such as drug effect, cancer, cirrhosis, dementia, and BUN, showed significant differences. Conclusions: In elderly patients, symptoms of delirium persist for three months after diagnosis. Private nursing care at home or nursing home placement, besides the assessment of delirium risk factors, is important for optimal care of elderly patients after hospitalization.

10.5812/semj.93460

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Prevalence of Complications of Diabetes and Risk Factors Among Patients with Diabetes in the Diabetes Clinic in Southeast of Iran

Iranian journal of diabetes and obesity (2021)

Hamed Taheri Roya Rafaiee Raheleh Rafaiee

Objective: Academic health services play an important role in the prevention and control of diabetes mellitus (DM) in Iran. This study aimed at determining the prevalence of DM-related complications and the associated risk factors among patients with DM in a university-affiliated outpatient diabetes clinic of a referral hospital in Southeast of Iran, Zahedan. Materials and Methods: This cross-sectional study was conducted from January to April 2019 in an academic diabetes clinic. A total of 334 patients with DM, whose characteristics (age, sex, family history of DM, and substance abuse), as well as laboratory and clinical information, were recorded in the baseline forms, were included. The relationship between variables were assessed by Pearson’s correlation coefficient at P-value< 0.05 and using SPSS version 20.0. Results: The mean age of the participants was 54.27 (±11.57) years. In these patients, DM type 2 was estimated at 99.1%, and the mean duration of the disease was 8.98 (±6.93) years. The findings showed that 77.2% of the patients had poor glycemic control. Also, 85.4% of the patients had fasting blood sugar (FBS) level >126 mg/dL. There was a significant relationship between insulin-dependent therapy and drug abuse (P-value <0.001). The prevalence of hyperlipidemia (68.9%), hypertension (50.6%), retinopathy (29.6%), nephropathy (11.7%), and neuropathy (12.3%) was also determined. Conclusion: The majority of the patients (77.2%) in this study had poor glycemic control, and 69.9% of them suffered from microvascular complications, macrovascular complications, or both. Therefore, frequent visits accompanied by patient education could help to better diabetes control

Outpatient clinic

Shahid

Cross-sectional study

10.18502/ijdo.v13i1.5745

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Spontaneous Latency in Adult Patients with Celiac Disease on a Normal Diet after Gluten-Free Diet: Case Series

Middle East Journal of Digestive Diseases (2022)

Alireza Bakhshipour Raheleh Rafaiee

Celiac disease (CeD) is an immune condition induced by the consumption of gluten-containing foods in genetically-predisposed persons. CeD, in addition to digestive disease, is a multisystem disorder. If untreated, it is potentially can be a dangerous disorder and lead to morbidity and even mortality. At present, the only treatment option is a lifelong gluten-free diet (GFD), and all authors recommended this regimen. To the best of our knowledge, there are rare reports of the complete remission of disorder on GFD and reintroduction of a normal diet in affected patients. In this report, we describe five patients with CeD who developed complete remission of clinical symptoms, histopathological changes, and serology on a gluten-containing diet. All patients had CeD based on a positive tissue transglutaminase antibody (TTG IgA) and typical histopathological changes in duodenal biopsy with the complete disappearance of symptoms on the GFD regimen. All patients followed GFD for a mean 4 (±0.54) years. In conclusion, this study has shown that some CeD patients diagnosed in adulthood can recover a normal mucosa after a long period of the gluten-containing diet without relapsing any clinical or biological symptoms of CeD.

Gluten free

Regimen

Tissue transglutaminase

10.34172/mejdd.2022.295

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Lapse and Relapse Rates in Narcotics Anonymous Versus Methadone Maintenance Treatment: A 12-Month Prospective Study

Iranian Journal of Psychiatry (2021)

Fahimeh Mohseni Kasra Rahimi Mohammad Niroumand Sarvandani Zhaleh Jamali Seyedeh Masoumeh Seyedhosseini Tamijani

Objective: The present study aimed to compare lapse and relapse-free survival between patients treated in Narcotics Anonymous (NA) groups and Methadone Maintenance Treatment (MMT) centers and to determine the relationship between social support scale and treatment outcome. Method: This study was a prospective, 12-month cohort study using the random sampling method to select 100 newcomer patients treated by the NA Association as well as 100 patients in MMT centers. The data were collected using a demographic questionnaire and Social Support Appraisals (SSA) scale at the onset of the study along with follow-up phone calls every other week. Results: All participants were male, aged between 18 and 65 with a mean (SD) age of 38.98 (± 10.85) years. Prevalence of relapse in 12 months was 60.5%. The lapses in the MMT group and relapses in the NA group were significantly higher (P < 0.001). The younger patients with lower levels of education are at greater risk of lapse/relapse. The mean score of SSA was significantly higher in the MMT group than the NA group in all subscales, including friends, family, and the others' support (P < 0.001). The mean scores of SSA subscales for the participants without relapse in the NA group was significantly higher in comparison to the MMT group. Conclusion: Detection of factors related to drug abuse relapse/lapse may help addiction therapists to identify drug abuse patients with lapse/relapse and to develop treatment and policy guidelines to prevent relapse in addiction recovery.

Methadone maintenance

Relapse prevention

10.18502/ijps.v17i1.8044

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Quality of Services in Substance Abuse Treatment Centers in Shahroud, Iran

International Journal of Health Studies (2015)

Raheleh Rafaiee Mohammad Reza Naqavi Leila Rezaiean Marzieh Moammeri Mohammad Hassan Emamian

Background: Standard cares in Substance Abuse Treatment Centers (SATC) have an important role in treatment success achievement. Patients’ views will provide valuable information to improve the performance of these centers. The purpose of current study was to determine patients’ comments on quality of addiction treatment at SATCs. Methods: This cross-sectional study was conducted in 2013. The study population consisted of addicted patients receiving methadone maintenance treatment (MMT) in SATCs of Shahroud. Using stratified sampling method, a total of 250 individuals were randomly selected from the SATCs. The SERVQUAL service quality model was used to measure service quality in five dimensions of tangibles, reliability, responsiveness, assurance, and empathy. Using paired samples t-test the gap between patients’ expectations of a service offering and the patients’ perceptions of the service received was analyzed by 5-dimensional structure of service quality Results: Overall, the score of patients’ expectations of service quality (4.45±0.67) was higher than that of their perceptions (4.24±0.0.76). For the dimensions of tangibles, reliability, responsiveness, assurance, and empathy, the mean difference between patients’ perceptions and expectations of the quality of addiction treatment services was -0.34, -0.17, -0.19, -0.14, and -0.24 respectively. All differences were statistically significant. Conclusions: Although the mean score of patients’ perceptions was good, the patients were not satisfied with the quality of addiction treatment services in the SATCs at Shahroud. The results showed that there is a gap between the current state and the desired state in terms of service quality in SATCs and this gap can be reduced by proper planning, management and training.

SERVQUAL

10.22100/ijhs.v1i1.39

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