Eko Naning Sofyanita

Diponegoro University

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Roni Afriansya

Politeknik Kesehatan Kemenkes Semarang

Mochamad Rizal Maulana

Politeknik Kesehatan Kemenkes Semarang

Mochamad Rizal Maulana

Politeknik Kesehatan Kemenkes Semarang

Utami Purnama Siwi

Politeknik Kesehatan Kemenkes Semarang

Tristania Shofi Nazhiifah

Politeknik Kesehatan Kemenkes Semarang

Dina Afrianti

Politeknik Kesehatan Kemenkes Semarang

Arya Iswara

Universitas Muhammadiyah Semarang

Lilik Setyowatiningsih

Politeknik Kesehatan Kemenkes Semarang

Nurul Qomariyah

Universitas Pekalongan

Putri Kurniasiwi

Politeknik Kesehatan Kemenkes Semarang

Cooperative Institutions

Politeknik Kesehatan Kemenkes Semarang

Ministry of Health

Diponegoro University

Universitas Muhammadiyah Semarang

Universitas Semarang

Sultan Agung Islamic University

Badan Penelitian dan Pengembangan Kesehatan

Universitas Nahdlatul Ulama Indonesia

Universitas Gadjah Mada

Universitas Muhammadiyah Sidoarjo

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Proteksi Biji Kopi Dalam Memperbaiki Morfologi Sperma Pada Tikus Yang Diinduksi Streptozotocin

Jurnal Laboratorium Khatulistiwa (2024)

Mochamad Rizal Maulana Eko Naning Sofyanita

Pemberian induksi Streptozotocin (Stz) dapat menurunkan kualitas sperma salah satunya morfologi sel spermatozoa, kopi mempunyai kandungan antikosidan yang tinggi yaitu asam klorogenat yang merupakan antioksidan kuat, mampu bertindak sebagai antioksidan eksogen yang melawan ROS dalam sel. Tujuan dari penelitian ini untuk mengatahui pengaruh pemberian kopi pada tikus yang diinduksi Stz. Post Test Control Group Design dengan sampel 24 tikus jantan Rattus norvegicus umur 3 bulan, berat badan ± 250 gram, dibagi menjadi 4 kelompok secara random. Setelah 1 minggu aklimasi, pengobatan diberikan 1 kali sehari selama 14 hari. Hari ke 15 dilakukan pemerkksaan morfologi sperma.. Hasil penelitian morfologi spermatozoa (%) pada kelompok KN (50,46) kelompok KP (64,58) kelompok KK1 (59,50) dan kelompok KK2 (72,05) berbeda artinya, p< 0,05. Kesimpulan pada penelitian ini yaitu Pemberian kopi mampu memperbaiki morfologi spermatozoa pada tikus yang diinduksi Stz.

10.30602/jlk.v7i2.1421

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Profile of Lymposites in New Tuberculosis (TB) Patients in Semarang City

Jurnal Surya Medika (2022)

Roni Afriansya Nurul Qomariyah Anung Sugihartono Eko Naning Sofyanita

The body's form of defense or natural immune response against intracellular bacteria is phagocytosis. Cells capable of phagocytosing macrophages in natural responses play a role in presenting antigens to lymphocytes in specific immune responses. The number of lymphocytes associated with the incidence of death in TB patients in hospitals. This study aims to determine the lymphocyte profile in pulmonary TB patients with new cases in the city of Semarang in 2020. This study uses a descriptive-analytic research design. The population in this study were new cases of pulmonary TB patients at the Semarang Health Center in 2020. The sample in this study was new cases of pulmonary TB patients at the Semarang Health Center from September to October 2020. The results showed that the newest cases of pulmonary TB were male (59%), and based on age the most were productive age (87.8%), and the lymphocyte profile of 78% of respondents had relative lymphopenia, 19.5% of respondents were normal and 2.4% of respondents experienced relative lymphocytosis. Overall, it can be said that the profile of patients with lymphopenia is 14.63%, and relative lymphopenia is 78%.

Lymphocytosis

Immune status

Immune Dysfunction

10.33084/jsm.v8i3.3681

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Bibliometric analysis of antibacterial activity of Centella asiatica: A study based on Scopus database

Journal of Applied Pharmaceutical Science (2023)

Asti Arum Sari Rima Munawaroh Eko Naning Sofyanita

Screening of proper leaf size in Centella asiatica for antioxidant potential and separation of phenolics using RP-HPLCRitisha N. Tatmiya, Kiran S. Chudasama, Vibhuti M. Jhala and Vrinda S. Thaker

Centella

10.7324/japs.2023.139686

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Effectiveness of white guava leaves (Psidium guajava var. Pyrifera l.) In repair proximal tubule damage and glomerulus diameter in hyperglycemic mice

ITEGAM- Journal of Engineering and Technology for Industrial Applications (ITEGAM-JETIA) (2023)

Eko Naning Sofyanita Anisa Rizky Yunianti

Diabetes Mellitus (DM) is a global health problem with a high prevalence rate in Indonesia, ranking 5th out of 10 countries with the highest number of diabetes cases. In 2019, Indonesia had the highest prevalence rate of diabetes mellitus at 9.3% (463 million) and an estimated increase to 12.2% (783 million) by 2045. The kidney, the primary organ affected by high glucose levels, is the primary organ affected by a compound. Guava leaves, which contain alkaloids, flavonoids, saponins, polyphenols, tannins, and calcium, have been found to have anti-diabetic properties.This research aimed to investigate the effect of variations in the number of white guava leaves used in making waters tew on kidney histopathology in alloxan-induced mice (Mus musculus). The mice were divided into five groups, with initial blood glucose levels measured after being induced by alloxan and after treatment with white guava seeds. After treatment, kidney histopathological preparations were made using Hematoxylin Eosin (HE) staining. The results showed that the average size of the proximal tubule proximal and glomerular diameter was larger than the positive (+) control group. The average glomerular diameter at K0, P1, P2, and P3 was smaller than the positive (+) control. The results of the study suggest that boiled water from white guava leaves may have potential therapeutic benefits for diabetics.

Histopathology

Psidium

Alloxan

10.5935/jetia.v9i41.863

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PENGARUH DAYA HAMBAT PERASAN BAWANG PUTIH TUNGGAL (Allium Sativum L) TERHADAP PERTUMBUHAN BAKTERI Salmonella typhi

Jurnal Laboratorium Khatulistiwa (2023)

Eko Naning Sofyanita

Typhoid fever is a disease caused by Salmonella typhi bacterial infection. This disease is one of the global infections throughout where the level of typhoid resistance to chloramphenicol in Indonesia itself is increasing, and it has even been reported that resistance increases 16% to 81% in 1 year in one location. Single garlic contains an active compound, namely allicin, which is used as an antibacterial which can inhibit the growth of gram-positive and gram-negative bacteria. Therefore, single garlic is expected to be used as an alternative in overcoming the problem of resistance to bacteria Salmonella typhi that causes typoid. This study used the disc diffusion method on MHA agar media to test the inhibition of single garlic juice against Salmonella typhi bacteria. This type of experimental research with descriptive criteria, with 4 repetitions. Results by measuring the diameter of the power area of the test sample in the concentration group of 50%, 75% and 100%. The results of this study the average diameter of the inhibitory power at a concentration of 100% is 25 mm, at a concentration of 75% is 21 mm, and at a concentration of 50 % i.e. 17 mm. The results of statistical tests with simple linear regression showed that p (0.000) <Î± 0.05 means that Ha is accepted, so it can be stated that there is an effect of various concentrations of single garlic (Allium Sativum L) on the inhibition zone of Salmonella typhi bacteria.

Agar diffusion test

10.30602/jlk.v6i2.630

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Gambaran Nilai Index Trombosit pada Pasien Tuberulosis Paru yang Mengonsumsi Obat Anti Tuberkulosis

Jaringan Laboratorium Medis (2023)

S.Y. Didik Widiyanto Nurul Qomariyah Eko Naning Sofyanita

Tuberculosis (TB) is a disease caused by the bacterium Mycobacterium tuberculosis which mostly attacks the lungs. Based on several studies, it is stated that tuberculosis sufferers who take OAT for healing experience side effects in the form of lowering the platelet index due to reactions from drugs that lyse platelets. This research is a descriptive study with a cross sectional design. Research was conducted on 30 respondents who consumed OAT. The results of this study obtained results of more than 50% on one of the platelet indices, namely the PWD value, which was obtained with low results with a total of 19 patients (63.3%), while for other indices such as platelet counts there were 21 patients (70%) , MPV in 28 patients (93%) and PCT in 23 patients (77%) had normal results. The conclusion of this study is that platelet index examinations in TB patients tend to be low in MPV and PDW, while they show high results in PLT and PCT examinations.

10.31983/jlm.v5i2.9646

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Deteksi Mandiri Sindrom Metabolik Pada Masyarakat Sebagai Pencegahan Penyakit Tidak Menular

ABDIMASKU JURNAL PENGABDIAN MASYARAKAT (2023)

Eko Naning Sofyanita Ririh Jatmi Wikandari

Sindrom metabolik dapat dikatakan sebagai faktor yang secara langsung dapat meningkatkan penyakit jantung koroer (PJK) dan diabetes mellitus tipe 2. Pravelensi sindrom metabolik di dunia sama besarnya dengan prevelensi obesitas.Â Penyakit ini akan memperburuk kondisi apabila gaya hirup tidak sehat. Kegiatan ini dilakukan di kelurahan sendangmulyo dengan sasaran 50 warga desa. Dalam kegaitan tersebut diperoleh data yaitu 14% kategori kurus, sebanyak 32% IMT normal, 16% kelebihan berat badan, 32% kategori obesitas 1 dan sebesar 6% kategori IMT obesitas 2. Berdasarkan hasil pemeriksaan dari 50 warga di kelurahan Sendangmulyo didapat hasil 5 orang (10%) terdeteksi mengalami sindrom metabolik, 17 orang (34%) mengalami diabetes melitus, 18 orang (36%) mengalami hipertensi dan 17 orang (34%) mengalami obesitas sentral serta 25 orang (50%) terdeteksi kadar koleterol tinggi. Kegiatan pengabdian yang dilakukan di kelurahan Sendangmulyo ini memberikan informasi dan edukasi tentang gangguan sindrom metabolik serta diharapkan Masyarakat dapat melakukan deteksi sindrom metabolik secara mandiri dengan mengukur IMT (berat badan, tinggi badan, dan lingkar perut), pemeriksaan tekanan darah, lingkar perut, pemeriksaan kolesterol dan gula darah.

10.62411/ja.v6i3.1541

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Correlation of climate factors and the number of SARS-CoV-2 cases at Semarang, Central Java

International Journal of Public Health Science (IJPHS) (2024)

Mochamad Rizal Maulana Eko Naning Sofyanita Adita Puspitasari Swastya Putri

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new type of coronavirus that has symptoms of acute respiratory distress in general. In more severe, it can cause kidney failure, pneumonia, and death. Environmental conditions that cannot be anticipated, such as climate factors, can have an impact on the transmission and survival of viruses, including the severe acute respiratory syndrome (SARS) viruses, which are responsible for the emergence of respiratory diseases. This research is a quantitative study using an ecological approach with secondary data from the Meteorology, Climatology, and Geophysics Agency (temperature, humidity, and precipitation), and SARS-CoV-2 cases were sourced from the Semarang City COVID-19 Task Force in 2021 were univariate and bivariate analyzing. The highest temperature average occurs in October (29.8 ⁰C), the humidity average occurs in February (91.4%), and the average precipitation occurs in February (1,130 mm). Analysis of the correlation found that there was a correlation between the SARS-CoV-2 cases with humidity (p=0.000; r=-0.245) and temperature (p=0.016; r=-0.127), but there was no correlation between precipitation (p=0.403; r=-0.044). Analysis of the influence of meteorological elements related to temperature, humidity, and precipitation on the incidence of COVID-19 in Semarang City in 2021, it can be concluded that there is correlation between temperature and humidity on COVID-19 cases except for precipitation.

Coronavirus

10.11591/ijphs.v13i4.24206

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PENGARUH PEMBERIAN EKSTRAK CONTINOUS MULTI-STAGE COUTERCURRENT EXTRACTION (CMCE) PROPOLIS TERHADAP KADAR FOLLICLE STIMULATING HORMONE (FSH), LUTEINIZING HORMONE (LH), DAN HORMON TESTOSTERON(Uji Pra-klinik Pada Tikus Wistar Jantan (Rattus norvegicus) Yang Diinduksi Monosodium Glutamate (MSG) )

Eko Naning Sofyanita

Latar belakang : Pemberian MSG telah terbukti dapat menurunkan kadar FSH, LH dan testosteron. Ekstrak propolis dengan metode Continous Multi-Stage Coutercurrent Extraction (CMCE) mengandung antioksidan kuat yang mampu bertindak sebagai radical scavenger. Penggunaan ekstrak CMCE propolis dalam meningkatkan kadar FSH, LH dan Testosteron pada tikus Wistar jantan yang diinduksi MSG belum pernah dilaporkan. Tujuan : Mengetahui pengaruh pemberian Ekstrak CMCE propolis terhadap peningkatan kadar FSH, LH dan Testosteron pada tikus Wistar jantan yang diinduksi MSG. Metode: Penelitian eksperimental dengan post test only control group design menggunakan sampel 18 ekor tikus Wistar jantan dan dibagi menjadi 3 kelompok. Kelompok kontrol, P1 dan P2 masing-masing diinduksi MSG 140mg kemudian pada P1 ditambah ekstrak CMCE propolis 8,3mg dan P2 10,8mg selama 21 hari, Hari ke-22 dilakukan pengambilan darah melalui sinus orbitalis kemudian diukur kadar FSH, LH dan Testosteron dengan metode ELISA. Hasil : Uji analisis anova menunjukan perbedaan bermakna antar kelompok p=0,000(p˂0,05). Analisis post hoc menunjukan kadar FSH, LH dan testosteron pada ekstrak CMCE propolis dosis 8,3mg dan 10,8mg berbeda bermakna dibanding kelompok kontrol p=0,000(p˂0,05). kadar FSH, LH dan testosteron pada ekstrak CMCE propolis 10,8mg lebih tinggi secara signifikan dibandingkan pada ekstrak CMCE propolis 8,3mg p=0,000(p˂0,05). Kesimpulan : Pemberian ekstrak CMCE propolis dosis 8,3mg dan 10,8mg dapat meningkatkan kadar FSH, LH dan Testosteron pada tikus Wistar jantan yang diinduksi MSG. Kata Kunci: ekstrak CMCE propolis, FSH, LH, Testosteron, Monosodium glutamate

Propolis

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Comparison Of Giving Three Types Of Honey On Exudate Weight In The Healing Process Of Acute Wounds In Balb/C Mice

Deleted Journal (2024)

Eko Naning Sofyanita

A wound is an injury where the skin is torn, cut or punctured, or a blunt force trauma causes a contusion. The use of honey as a wound treatment has been widely used, but the comparison of accelerated wound healing using three types of honey originating from Indonesia is not yet known. From the results of the study that on days 1 to 7 the MD-NTT group could reduce exudate weight better than the MD-JW, MD-KLM, and K-MD. The conclusion in this study is that the use of honey originating from NTT can be an alternative to healing acute wounds infected with bacteria.

Exudate

BALB/c

10.59435/jgrp.v1i1.2024.2

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