Maria das Graças Almeida

Universidade Federal do Rio Grande do Norte

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Adriana Augusto de Rezende

Universidade Federal do Rio Grande do Norte

José Brandão‐Néto

Universidade Federal do Rio Grande do Norte

Marcela Abbott Galvão Ururahy

Universidade Federal do Rio Grande do Norte

Ricardo Fernando Arrais

Universidade Federal do Rio Grande do Norte

Melina Bezerra Loureiro

Universidade Federal do Rio Grande do Norte

Jefferson Romáryo Duarte da Luz

Universidade Estadual do Amapá

Gabriel Araújo da Silva

Universidade Estadual do Amapá

Jorge A. López

Universidade Tiradentes

Raul Hernandes Bortolin

Universidade de São Paulo

Karla Simone Costa de Souza

Universidade Federal do Rio Grande do Norte

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Universidade Federal do Rio Grande do Norte

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Universidade de São Paulo

Universidade Federal do Rio Grande

Universidade Federal de São Paulo

Universidade Federal da Paraíba

Universitat Autònoma de Barcelona

Universidade Federal de Pernambuco

Hospital Universitário Onofre Lopes

Instituto de Ciências Farmacêuticas

Josep Carreras Leukaemia Research Institute

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Avaliação de parâmetros antioxidantes em ratos tratados com sevoflurano

Brazilian Journal of Anesthesiology (2010)

Francisco José Lucena Bezerra Nilton Bezerra do Vale Brunno de Oliveira Macedo Adriana Augusto de Rezende Maria das Graças Almeida

JUSTIFICATIVA E OBJETIVOS: O sevoflurano é um éter halogenado com flúor que sofre biotransformação hepática através do citocromo P450 2E1. Éteres halogenados que sofrem biotransformação pelo P450 2E1 podem produzir espécies reativas do oxigênio (ERO) e promover enfraquecimento do sistema de defesa antioxidante. O objetivo deste trabalho foi investigar a relação entre a atividade das enzimas antioxidantes eritrocitárias e o sevoflurano. MÉTODO: Os animais foram distribuídos em quatro grupos: Grupo 1 controle: apenas oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos); Grupo 2 - sevoflurane 4,0% em oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos); Grupo 3 - isoniazida (i.p.), 50 mg.kg-1 de peso corporal /dia, durante 4 dias e em seguida tratados apenas com oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias consecutivos); Grupo 4 - isoniazida por via intraperitoneal na dose de 50 mg.kg-1 de peso corporal, diariamente durante 4 dias, seguido da administração do sevoflurane a 4,0% em oxigênio a 100% (1 L.min-1 por 60 minutos durante 5 dias). Após 12 horas da última exposição ao sevoflurane, os animais foram sacrificados e o sangue foi coletado através da veia porta para análise da atividade das enzimas antioxidantes. RESULTADOS: Aumento da atividade específica da glicose-6-fosfato desidrogenase, diminuição da atividade específica da catalase, principalmente no grupo de animais pré-tratados com isoniazida e, em seguida, tratados com sevoflurano. A glutationa peroxidase não apresentou alteração na sua atividade. CONCLUSÕES: A interação do sevoflurano com indutores enzimáticos do citocromo P450 2E1 pode propiciar a instalação do estresse oxidativo caso a exposição se torne prolongada e repetitiva.

10.1590/s0034-70942010000200008

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Citations (5)

Investigation ofTurnera ulmifoliaeffects in pregnant rats and offspring

Pharmaceutical Biology (2009)

Luana Janine Lopes da Costa Valéria Cristina Ribeiro Dantas Tatiane Pereira de Souza Luiz Alberto Lira Soares Maria das Graças Almeida

10.1080/13880200902995533

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Physicochemical, Sensory, Microbiological And Antioxidant Characterization Of A Jelly Made From Tacinga Inamoena

Journal of Culinary Science & Technology (2022)

Jefferson Romáryo Duarte da Luz Andréia da Cunha Bezerra Rubiamara Mauricio de Sousa Macelia Pinheiro Ferreira Débora Batista

Quipá (Tacinga inamoena) is a plant native to Northwestern Brazil which contains valuable minerals in its composition that are of great interest to the scientific community. The purpose of this study was to assess the physicochemical, antioxidant, sensory and microbiological properties of a quipá-based gelatinous sweet. The jelly presented a high concentration of carbohydrates and soluble fibers, being free of microbiological contamination, a good sensorial acceptance, and was therapeutic in terms of antioxidant effects. Due to its ability to chelate copper and ferric ions, the jelly was also responsible for an 80% reduction in DPPH and a preventative activity against oxidative damage. This product contains a high amount of active ingredients, such as phenolic compounds, which have biological benefits effects in disease prevention and health promotion. The quipá jelly provides benefits, functional properties, and advantages, which may be of interest to the industrial sector.

10.1080/15428052.2022.2112352

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Efeito da suplementação com zinco sobre a zincúria de pacientes com diabetes tipo 1

Arquivos Brasileiros de Endocrinologia & Metabologia (2003)

Karine Cavalcanti Maurício de Sena Ricardo Fernando Arrais Tereza Neuma Souza Brito Maria das Graças Almeida Lúcia Fátima Campos Pedrosa

Neste estudo foi investigado o efeito da suplementação oral de zinco (Zn) em crianças e adolescentes com diabetes (DM), avaliando o controle metabólico da doença e concentrações de Zn na urina. A amostra foi constituída por 20 pacientes com DM tipo 1, os quais foram comparados com um grupo controle (n=17). O controle metabólico foi avaliado pela glicemia de jejum, glicosúria 24h e HbA1c. As concentrações de Zn foram investigadas na urina de 24h antes (T1) e após a suplementação (T2). Após a 1a coleta de dados dos pacientes com DM1 (T1), teve início a suplementação oral com Zn bis-glicina quelato sem sabor, por um período de 4 meses. As doses foram estabelecidas baseadas nas Dietary Reference Intakes. Os resultados evidenciaram um controle metabólico insatisfatório da doença, devido ao aumento da HbA1c de alguns pacientes, após a suplementação. A excreção urinária de Zn foi maior nos pacientes com DM1 e esteve correlacionado positivamente com o tempo de doença e HbA1c. A suplementação com Zn não corrigiu a heterogeneidade na variação circadiana da zincúria nos pacientes estudados, sugerindo que o controle metabólico inadequado no DM predispõe a distúrbios no metabolismo do Zn, independente da fonte, alimentar ou medicamentosa.

10.1590/s0004-27302003000500011

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Citations (7)

Antioxidant activity and protective effect of Turnera ulmifolia Linn. var. elegans against carbon tetrachloride-induced oxidative damage in rats

Food and Chemical Toxicology (2012)

Naira Josele Neves de Brito Jorge A. López Maria Aparecida do Nascimento José Benilson Martins Macedo Gabriel Araújo da Silva

The present study aimed to determine whether the leaves of Turnera ulmifolia Linn. var. elegans extract exert significant antioxidant activity. The antioxidant activity of its hydroethanolic extract (HEETU) was evaluated by assessing (a) its radical scavenging ability in vitro, and (b) its in vivo effect on lipid peroxidation and antioxidant enzyme activities. The in vitro antioxidant assay (DPPH) clearly supported HEETU free radical scavenging potential. Moreover, glutathione content and antioxidant enzyme activities (glutathione peroxidase, superoxide dismutase and catalase) were significantly enhanced in CCl(4)-treated rats due to oral HEETU-treatment (500 mg/kgb.w.) over 7 and 21 days. In addition, an improvement was observed in lipid peroxidation and serum biochemical parameters (aspartate aminotransferase and alanine aminotransferase), indicating a protective effect against CCl(4)-induced liver injuries, confirmed by histopathological studies. The HEETU effect was comparable to the standard drug Legalon® (50 mg/kgb.w.) under the same experimental condition. Quantitative analysis of the HPLC extract revealed the presence of flavonoids, wich mediate the effects of antioxidant and oxidative stress. In conclusion, extract components exhibit antioxidant and hepatoprotective activities in vitro and in vivo.

10.1016/j.fct.2012.08.003

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Citations (21)

IL-1B and TNF-A genes associated with microalbuminuria onset in T1DM pediatric patients from Brazil

Diabetes (2012)

Marcela Abbott Galvão Ururahy Karla Simone Costa de Souza Yonara Monique da Costa Oliveira Melina Bezerra Loureiro Heglayne Pereira Vital da Silva

Microalbuminuria

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Chemical composition, antioxidant activity and hepatoprotective potential of Rourea induta Planch. (Connaraceae) against CCl4-induced liver injury in female rats

Nutrition (2013)

Milena Kalegari Carlos Alberto Bruel Gemin Gabriel Araújo da Silva Naira Josele Neves de Brito Jorge A. López

The aim of this study was to evaluate the flavonoid content of an ethanolic leaf extract from the medicinal plant Rourea induta Planch. (RIEE) and to investigate its hepatoprotective potential and in vivo antioxidant effects.Using samples from carbon tetrachloride-treated Wistar female rats treated orally with or without RIEE, we evaluated the aspartate aminotransferase, alanine aminotransferase, and total bilirubin levels in plasma; the levels of the hepatic oxidative stress markers catalase, superoxide dismutase, glutathione peroxidase, and reduced glutathione in liver homogenates; and the thiobarbituric acid reactive substance levels. A histopathology study was performed. A quantitative analysis of the RIEE extract was performed using high-performance liquid chromatography to evaluate its flavonoid content.Oral administration of RIEE significantly reduced carbon tetrachloride-induced elevations in the levels of plasma markers of hepatic damage and lipid peroxidation. It also rescued histopathologic alterations observed in the liver and levels of oxidative stress markers.RIEE exhibits antioxidant and hepatoprotective activities in vivo, which may be attributable to its flavonoids composition [hyperin (2), quercetin-3-O-β-xyloside (4), quercetin-3-O-α-arabinofuranoside (5), and quercetin (6)].

Thiobarbituric acid

10.1016/j.nut.2013.11.004

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Citations (27)

Relationship between CD38 expression on peripheral blood T‐cells and monocytes, and response to antiretroviral therapy: A one‐year longitudinal study of a cohort of chronically infected ART‐naive HIV‐1+ patients

Cytometry Part B Clinical Cytometry (2006)

Maria das Graças Almeida Miguel Cordero Júlia Almeida Alberto Órfão

HIV-1 infection has been associated with high expression of CD38 on peripheral blood (PB) CD8+ and CD4+ T-cells, which has been related with poor prognosis in untreated HIV-1+ patients. In turn, CD38 expression on PB monocytes from HIV-1+ individuals and its behavior after starting antiretroviral therapy (ART) have been poorly studied.CD38 expression on PB CD8+ and CD4+ T-lymphocytes and monocytes was prospectively analyzed in 30 ART-naive HIV-1+ patients, using a quantitative multiparameter flow cytometry approach. Patients were tested prior to therapy, and at weeks +2, +4, +8, +12, and +52 after ART.Prior to ART, CD38 expression was significantly increased on PB CD8+ and CD4+ T-cells and monocytes; despite a significant decrease after ART, CD38 expression remained abnormally high on PB CD8+ T-cells and monocytes, even after one year of therapy, in the absence of detectable plasma viral load. The ART-induced early changes on CD38 expression by PB T-cells and monocytes differed among the cell subsets analyzed and patient groups, probably reflecting an interaction between the direct effects of therapy and a redistribution of the PB compartments of T-cells and monocytes. Hierarchical clustering analysis showed that the overall pattern of changes in CD38 expression observed early after starting ART was predictive of a better response to therapy, not only for PB CD8+ T-cells, but also for CD4+ T-cells and monocytes. Accordingly, those HIV-1+ patients, who experienced a more pronounced increase in CD38 expression on both PB CD4+ T-cells and monocytes after 2 weeks of ART, showed a more rapid viral clearance, which might reflect decreased HIV-1 replication in lymph nodes and other tissues, and a partial restoration of hematopoiesis.Combined quantitative measurement of CD38 expression on PB monocytes, and CD8+ and CD4+ T-cells is a more useful tool for monitoring HIV-1+ patients under ART, rather than quantitation of CD38 expression on PB CD8+ T-lymphocytes alone.

Immunophenotyping

Monocyte

10.1002/cyto.b.20144

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Citations (32)

Zinc supplementation reduces RANKL/OPG ratio and prevents bone architecture alterations in ovariectomized and type 1 diabetic rats

Nutrition Research (2017)

Elaine C Ferreira Raul Hernandes Bortolin Francisco Paulo Freire‐Neto Karla Simone Costa de Souza João Felipe Bezerra

Bone remodeling

Osteopenia

10.1016/j.nutres.2017.03.004

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