Shahriar Zohourian Shahzadi

Iran University of Medical Sciences

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Alireza Azani

Tehran University of Medical Sciences

Fabio Facchetti

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

M. Javadi

University of Shahrood

Luisa Lorenzi

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Saleh Mohebbi

Iran University of Medical Sciences

Shiva Farmani

Yazd University

Atousa Moghadam Fard

Universal Scientific Education and Research Network

Sara Behafarid

Kurdistan University of Medical Sciences

SeyedAbbas Pakmehr

Shiraz University of Medical Sciences

Ali Jamshidi Naeini

Iran University of Medical Sciences

Cooperative Institutions

Tehran University of Medical Sciences

Iran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

University of Tehran

Rasool Akram Hospital

Kurdistan University of Medical Sciences

Medical University of Ilam

Imam Khomeini Hospital

Tabriz University of Medical Sciences

Islamic Azad University, Science and Research Branch

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Sialolipoma of the Parotid Gland with Diffuse Sebaceous Differentiation in a Female Child

Pediatric and Developmental Pathology (2007)

Maryam Kadivar Shahriar Zohourian Shahzadi Morteza Javadi

Sialolipoma of the salivary gland is a tumor with ambiguous histogenesis. Histologically, this lesion is composed of mature adipose tissue and salivary glandular components. To the best of our knowledge, only 12 documented cases of sialolipoma have been reported in the literature. Except for 1 congenital case, all of the cases were found in adult patients. In this report, we present a unique case of sialolipoma with diffuse sebaceous differentiation in a 3-year-old female child. The differential diagnoses are discussed.

Histogenesis

Choristoma

10.2350/06-05-0091.1

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Citations (29)

Evaluation of Methylation and Changes in the Transcriptomics and Proteomics of the GRHL3, PHLDA3, and in Patients with Head and Neck Squamous Cell Carcinoma

Indian Journal of Otolaryngology and Head & Neck Surgery (2024)

Abbas Shakoori Maryam Azarian Mahdi Hosseinpour Aghaei Moein Maddahi Kayvan Aghazadeh

10.1007/s12070-024-05057-0

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Immunohistochemical Assessment of Neuroendocrine Differentiation in Colorectal Carcinomas and Its Relation with Age, Sex and Grade Plus Stage

Iranian journal of pathology (2009)

Nasrin Shayanfar Shahriar Zohourian Shahzadi

Background and Objective: Neuroendocrine differentiation has not been proved to have effects in behavior of colorectal carcinomas. The aim of this study was Immunohistochemical evaluation of neuroendocrine differentiation in colorectal cancer. Patients and Methods: In this cross-sectional study, 83 paraffin blocks from patients admitted in Rasoul-e-akram Hospital, Tehran, Iran, during 2003 to 2008, were evaluated in Pathology Department. All sections were stained with immunohistochemistry method for neuron specific enolase (NSE) and Chromogranin A(CgA). Data were analyzed using SPSS 12.0. Results: Median age of patients was 56 yr. Forty four cases (53%) were female. According to TNM staging system, 11% of cases were in stage I, 29% in IIa, 7% in IIb, 2% in IIIa, 23% in IIIb, 24% IIIc and 2% were in stage IV. Thirteen cases (16%) were NSE positive, 15 cases (18.1%) were CgA positive. Two, 8 and 5 percent of the patients in grade I, II and III were CgA positive, respectively. Two, 6 and 5 percent of the patients in grade I, II and III were NSE positive. In grades II and III, NSE and CgA were significantly higher than grade I (P<0.001). CgA incidence was higher significantly in mucinous carcinomas (P<0.05). Conclusion: Less than 20% of colorectal cancers showed neuroendocrine differentiation. There was no significant relationship between NSE and CgA incidence with stage or tumor site. There was a relationship between histologic grade and above-mentioned markers; this finding may help us in our knowledge about tumor behavior.

Chromogranin A

Neuroendocrine differentiation

Enolase

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Citations (2)

Sialolipoma of the parotid gland with diffuse sebaceous differentiation in a female child

Pediatric and Developmental Pathology (2006)

maryam kadivar Shahriar Zohourian Shahzadi M. Javadi

Sebaceous gland

10.2350/06-05-0091

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Citations (2)

Parapharyngeal lymph node as an isolated manifestation of follicular dendritic cell sarcoma: First report in Iran

Radiology Case Reports (2023)

Rambod Mozafari Karo Servatyari Luisa Lorenzi Fabio Facchetti Shahriar Zohourian Shahzadi

Follicular dendritic cell sarcoma (FDCS) is a rare type of sarcoma that originates from the stromal component of the germinal center of the B-follicle. Its presentation and prognosis vary, as it can be nodal or extranodal, localized or multifocal, and can be fatal in 20% of cases. Due to its rarity, FDCS diagnosis requires a high level of suspicion. Most cases have been reported in Europe or the United States, and no cases have been previously reported in individuals of Iranian descent. This case report describes a 33-year-old Iranian man with no significant medical history who presented with a palpable nodule in the neck and odynophagia. Magnetic resonance imaging revealed a mass with heterogeneous enhancement in the parapharyngeal space. Pathological examination confirmed FDCS, likely localized to a parapharyngeal lymph node with no extranodal involvement. The patient underwent radiation therapy and remained disease-free 28 months after diagnosis.

Parapharyngeal space

Nodule (geology)

Follicular dendritic cells

10.1016/j.radcr.2023.07.051

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Parotid Masson's Tumor in a 29-years-old woman: A Case Report.

PubMed (2023)

Saleh Mohebbi Shahriar Zohourian Shahzadi Ali Jamshidi Naeini

Intravascular papillary endothelial hyperplasia (IPEH) is a papillary hyperplasia of the endothelial vascular cells, also called Masson's tumor. Masson's etiology and risk factors remain unclear but trauma and vascular pathologic conditions may start the tumor process from its common regions like extremities. Common presentations include swelling and mild pain. Our Radiologic modality of choice is Contrast-enhanced MRI which can help us before operating parotidectomy, the gold standard of tumor treatment. As presented in this study, Parotid Masson's tumor, is a very rare form of Masson's,making it even more exceptional.This paper reports a case of a 29-years-old woman with a mass in herright parotid gland from 17 years ago, which has slowly increased in size during these years. She underwent a total parotidectomy following unsuccessful Fibrovein injections, which caused her inflammation. Embolization was performed before the resection to decrease the risk of its hemorrhage. Postoperative follow-up confirmed the reliability of this treatment method as the patient declared no side effects. Apart from its tough diagnosis, since Masson's tumors, especially the ones that emerge in the parotid, are rare, we decided to introduce this case to deliver more information about the treatment and diagnosis of this rare disease to other colleagues.The prognosis of parotid Masson's is admirable following a total resection. The patient had no postoperative complaints with no need for multiple visits after resection.

Parotidectomy

Etiology

10.22038/ijorl.2023.58567.3288

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Citations (1)

Effect of genetic profiling on surgical decisions at hereditary colorectal cancer syndromes

Heliyon (2024)

Yasaman Goudarzi Khaterehsadat Monirvaghefi Salar Aghaei Seyed Siamak Amiri Rezaei Mahdi

Hereditary colorectal cancer syndromes, such as Lynch syndrome and familial adenomatous polyposis (FAP), present significant clinical challenges due to the heightened cancer risks associated with these genetic conditions. This review explores genetic profiling impact on surgical decisions for hereditary colorectal cancer (HCRC), assessing options, timing, and outcomes. Genotypes of different HCRCs are discussed, revealing a connection between genetic profiles, disease severity, and outcomes. For Lynch syndrome, mutations in the MLH1, MSH2, MSH6, and PMS2 genes guide the choice of surgery. Subtotal colectomy is recommended for patients with mutations in MLH1 and MSH2, while segmental colectomy is preferred for those with MSH6 and PMS2 mutations. In cases of metachronous colon cancer after segmental colectomy, subtotal colectomy with ileorectal anastomosis is advised for all mutations. Surgical strategies for primary rectal cancer include anterior resection or abdominoperineal resection (APR), irrespective of the specific mutation. For rectal cancer occurring after a previous segmental colectomy, proctocolectomy with ileal pouch-anal anastomosis (IPAA) or APR with a permanent ileostomy is recommended. In FAP, surgical decisions are based on genotype-phenotype correlations. The risk of desmoid tumors post-surgery supports a single-stage approach, particularly for certain APC gene variants. Juvenile Polyposis Syndrome (JPS) surgical decisions involve genetic testing, polyp characteristics with attention to vascular lesions in SMAD4 mutation carriers. However, genetic profiling does not directly dictate the specific surgical approach for JPS. In conclusion this review highlights the critical role of personalized surgical plans based on genetic profiles to optimize patient outcomes and reduce cancer risk. Further research is needed to refine these strategies and enhance clinical guidelines.

Lynch Syndrome

MSH6

PMS2

MSH2

Proctocolectomy

MLH1

Ileostomy

Adenomatous polyposis coli

10.1016/j.heliyon.2024.e34375

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Citations (3)

CD44+ cancer cells express higher levels of the anti-apoptotic protein Bcl-2 in breast tumours.

PubMed (2009)

Zahra Madjd A Zare Mehrjerdi Ali Mohammad Sharifi Saadat Molanaei Shahriar Zohourian Shahzadi

Breast tumours consist of phenotypically diverse populations of breast cancer cells of which only a minority has the ability to form new tumours. The capacity for breast tumour development has been shown to be restricted to breast cancer stem cells with the CD44+/CD24(-/low) phenotype. These cells can resist apoptosis through mechanisms such as the regulation of Bcl-2. Identification of this population of cells is important because of its implication in the development of new therapeutic strategies. One hundred and forty-six primary operable breast cancer patients were investigated in order to identify the population of CD44+ and Bcl-2+ cells in paraffin-embedded tissues by immunohistochemistry. The prevalence of these phenotypes was then correlated with clinicopathological features. CD44 and Bcl-2 expression was detected in 86% and 82% of breast tumours, respectively. There was no significant correlation between CD44+ tumour cell prevalence and tumour characteristics, whereas the prevalence of CD44+ cells was associated with higher levels of Bcl-2 expression (P = 0.004). In univariate analysis, Bcl-2 expression was correlated with breast tumours of lower grade (P < 0.001) and fewer lymphatic metastases (P < 0.05). Our findings suggest that the prevalence of CD44+ tumour cells as a subpopulation of breast cancer stem cells was of no clinicopathological significance, but was correlated with higher Bcl-2 expression. This population of tumour cells may thus be more resistant to apoptosis. Targeting these cells in combination with current treatments may be more effective in treating breast cancer patients.

Side population

CD24

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Citations (97)