The prostanoids are a family of biologically active lipids derived from the 20-carbon essential fatty acids (LCPUFA) which are involved in all aspects of the immune response including the resolution of inflammation. ω3-fatty acids, EPA DPA and DHA are anti-inflammatory, whilst the ω6-fatty acid, Arachidonic acid (AA) and its metabolites: 13(S)-HETE, TXB2, PGF2α and 6-k-PGF1α are pro-inflammatory. Liquid Chromatography Tandem Mass Spectrometry (LC-MSMS) allows analyses of multiple prostanoids with high accuracy using 3 mm blood spots. This method has never been used in JIA and may find biomarkers which can help predict disease activity and treatment response.
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