V. Suzanne Klimberg

The University of Texas Medical Branch at Galveston

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Ronda Henry‐Tillman

University of Arkansas for Medical Sciences

Soheila Korourian

University of Arkansas for Medical Sciences

Kirby I. Bland

University of Alabama at Birmingham

Yihong Kaufmann

University of Arkansas for Medical Sciences

Kent C. Westbrook

University of Arkansas for Medical Sciences

Valentina K. Todorova

University of Arkansas for Medical Sciences

Edward M. Copeland

University of Florida

Cristiano Boneti

Creative Commons

Eric R. Siegel

University of Arkansas for Medical Sciences

Laura Adkins

University of Arkansas for Medical Sciences

Cooperative Institutions

University of Arkansas for Medical Sciences

192

Florida College

University of Florida

Breast Center

Cedars-Sinai Medical Center

The University of Texas MD Anderson Cancer Center

Winthrop Rockefeller Foundation

Central Arkansas Veterans Healthcare System

Yale University

Memorial Sloan Kettering Cancer Center

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Outer Breast Quadrants Demonstrate Increased Levels of Genomic Instability

Breast Diseases A Year Book Quarterly (2005)

V. Suzanne Klimberg

10.1016/s1043-321x(05)80185-7

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Citations (2)

Increased infiltration of activated tumor-infiltrating lymphocytes after high intensity focused ultrasound ablation of human breast cancer

Breast Diseases A Year Book Quarterly (2009)

V. Suzanne Klimberg

High-intensity focused ultrasound

Infiltration (HVAC)

Tumor-infiltrating lymphocytes

Tumor ablation

10.1016/s1043-321x(09)79352-x

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Citations (3)

Just Because You Can?

Surgical Laparoscopy Endoscopy & Percutaneous Techniques (2001)

V. Suzanne Klimberg

From the Division of Breast Surgical Oncology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, U.S.A. Address correspondence and reprint requests to V. Suzanne Klimberg, MD, Director, Division of Breast Surgical Oncology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Slot 725, Little Rock, Arkansas 72205, U.S.A.

Reprint

Center (category theory)

10.1097/00129689-200112000-00004

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Citations (7)

Trends in leadership at breast surgical oncology fellowships

Global Surgical Education - Journal of the Association for Surgical Education (2022)

Benjamin Schachner Dino Fanfan Zachary Zippi Jessica Moore Charles M. Balch

Surgical oncology

10.1007/s44186-022-00046-9

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Citations (1)

Use of Ultrasound in Breast Surgery

Surgical Clinics of North America (2007)

Margaret E. Thompson V. Suzanne Klimberg

10.1016/j.suc.2007.02.002

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Citations (14)

Glutamine supplementation reduces glutathione levels and stimulates apoptosis in DMBA-induced mammary tumors

Journal of Surgical Research (2003)

V.K. Todorova Yihong Kaufmann Stephen Y. Luo S.A. Harms Kirk Babb

Mammary tumor

10.1016/j.jss.2003.08.019

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Citations (10)

Issue Information

The Breast Journal (2019)

Shahla Masood Benjamin M. Anderson Seattle Wa William D. Anderson Hamdy A. Azim

The Breast Journal is a multidisciplinary publication with an equal partnership of different specialties and a focused approach toward enhancing our understanding of breast disease.The Breast Journal's editorial philosophy recognizes the increasing cooperation and interdependence of specialists who diagnose and treat diseases of the breast.Manuscripts will be considered in the form of editorials, original articles, fi rst time case reports, short communications, breast images, and letters to the editor.Submission of a paper implies that it reports unpublished work, except in abstract form, and is not being submitted simultaneously to another publication.

10.1111/tbj.13077

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Citations (1)

Unusual Tumors of the Breast

Current Problems in Surgery (2009)

Kristin Cox Soheila Korourian V. Suzanne Klimberg

10.1067/j.cpsurg.2009.03.003

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Citations (9)

Immunomodulatory Effects of Radiofrequency Ablation in a Breast Cancer Model

Immunological Investigations (2010)

Valentina K. Todorova V. Suzanne Klimberg Leah Hennings Thomas Kieber‐Emmons Anastas Pashov

Radiofrequency ablation (RFA), a minimally invasive surgical procedure has an increasing application in the surgical treatment of tumors. Data indicate that RFA might stimulate anti-cancer immunity possibly through the induction of necrosis and heat shock proteins (HSP) expression. This study tests a hypothesis that RFA leads to bidirectional immunoregulation. Experimental rat breast tumors were treated with RFA, surgical excision or sham operation. RFA resulted in the highest NK cells infiltration, increased HSP70 expression and activation of caspase-3 enzyme in the tumor margins. A significant reduction of the circulatory regulatory T (Treg) cells was found in both RFA- and excision-treated rats, although less pronounced in the RFA-group. The splenocyte proliferation to tumor cell lysate was stronger in the RFA-treated rats in comparison with untreated tumor-bearing rats. The potential role of self-HSP for immunomodulation was examined using in vitro proliferation assay to tetanus toxoid using human peripheral leukocytes. The response to the tetanus toxoid was significantly suppressed by HSP90 plus auto-antibodies versus HSP90 or auto-antibodies alone. In conclusion, RFA reduced the circulatory Tregs although not as efficient as tumor excision. HSPs plus natural antibodies suppress the anti-tumor response probably by stimulating Tregs. Therefore, RFA may play a role in anti-cancer therapy if combined with Tregs suppression.

Splenocyte

Toxoid

10.3109/08820130903428291

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Citations (22)

Biomarkers for Presymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients

PLoS ONE (2016)

Valentina K. Todorova Issam Makhoul Eric R. Siegel Jeanne Y. Wei Annjanette Stone

Cardiotoxicity of doxorubicin (DOX) remains an important health concern. DOX cardiotoxicity is cumulative-dose-dependent and begins with the first dose of chemotherapy. No biomarker for presymptomatic detection of DOX cardiotoxicity has been validated. Our hypothesis is that peripheral blood cells (PBC) gene expression induced by the early doses of DOX-based chemotherapy could identify potential biomarkers for presymptomatic cardiotoxicity in cancer patients. PBC gene expression of 33 breast cancer patients was conducted before and after the first cycle of DOX-based chemotherapy. Cardiac function was evaluated before the start of chemotherapy and at its completion. Differentially expressed genes (DEG) of patients who developed DOX-associated cardiotoxicity after the completion of chemotherapy were compared with DEG of patients who did not. Ingenuity database was used for functional analysis of DEG. Sixty-sevens DEG (P<0.05) were identified in PBC of patients with DOX-cardiotoxicity. Most of DEG encode proteins secreted by activated neutrophils. The functional analysis of the DEG showed enrichment for immune- and inflammatory response. This is the first study to identify the PBC transcriptome signature associated with a single dose of DOX-based chemotherapy in cancer patients. We have shown that PBC transcriptome signature associated with one dose of DOX chemotherapy in breast cancer can predict later impairment of cardiac function. This finding may be of value in identifying patients at high or low risk for the development of DOX cardiotoxicity during the initial doses of chemotherapy and thus to avoid the accumulating toxic effects from the subsequent doses during treatment.

Cardiotoxicity

10.1371/journal.pone.0160224

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Citations (24)