Min Dai

Anhui University of Traditional Chinese Medicine

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Qifa Liu

Southern Medical University

Hongfei Wu

Anhui University of Traditional Chinese Medicine

Yulong Yang

Anhui University of Traditional Chinese Medicine

Hua Jin

Southern Medical University

Huien Zhan

First Affiliated Hospital of Jinan University

Juan Du

First Affiliated Hospital of Jinan University

Jun Lyu

First Affiliated Hospital of Jinan University

Yang Xu

Soochow University

Jihao Zhou

Southern University of Science and Technology

Minyi Zhao

First Affiliated Hospital of Xi'an Jiaotong University

Cooperative Institutions

Southern Medical University

Nanfang Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

Anhui University of Traditional Chinese Medicine

Chinese Academy of Sciences

Sun Yat-sen University

Peking University

Central South University

Fudan University

Guangdong Academy of Medical Sciences

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A Two-Year Follow-Up Of a Prospective Study Of Intensified Conditioning Regimen With High-Dose-Etoposide Allogeneic Hematopoietic Stem Cell Transplantation For Adult Acute Lymphoblastic Leukemia In China

Blood (2013)

Hongsheng Zhou Zhiping Fan Fen Huang Yu Zhang Min Dai

Minimal Residual Disease

Regimen

Cumulative incidence

Acute lymphocytic leukemia

10.1182/blood.v122.21.4570.4570

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[Expression of Wilms' Tumor 1 Gene in Bone Marrow of Patients with Myelodysplastic Syndrome and Its Clinical Significance].

PubMed (2022)

Danqi Pan Wenshu Zhao Changxin Yin Han He Ren Lin

To investigate the expression level and clinical significance of Wilms' tumor 1 (WT1) in bone marrow of patients with myelodysplastic syndromes (MDS).The clinical data of 147 MDS patients who accepted real-time quantitative polymerase chain reaction (RT-PCR) to detect the expression level of WT1 in bone marrow before treated in Nanfang Hospital, Southern Medical University from January 2017 to April 2021 were retrospectively analyzed. According to the expression level of WT1, the patients were divided into WT1+ group and WT1- group, their clinical characteristics and prognosis were analyzed.The positive rate of WT1 in 147 MDS patients was 82.3%. There were significant differences in bone marrow blast count, aberrant karyotypes, WHO 2016 classification, and IPSS-R stratification between WT1+ group and WT1- group (all P<0.05). Furthermore, the higher the malignant degree of MDS subtype and the risk stratification of IPSS-R, the higher expression level of WT1. Compared with WT1- group, there were no differences in overall survival (OS) time and the time of transformation to AML in WT1+ group (both P>0.05). In patients who did not accept transplantation, the median OS time of WT1+ patients was significantly shorter than that of WT1- patients (P=0.049). Besides, regarding WT1+ group, patients who underwent transplantation had longer OS time and lower mortality than those who received hypomethylating agents (P=0.002, P=0.005).WT1 expression level directly reflects the disease progression, and it is also associated with prognosis of MDS patients.WT1基因在骨髓增生异常综合征患者骨髓中的表达及其临床意义.探究WT1基因在骨髓增生异常综合征（MDS）患者骨髓中的表达水平及其临床意义。.回顾性分析2017年1月至2021年4月在南方医科大学南方医院就诊的147例初发MDS患者的临床资料，应用实时荧光定量PCR检测骨髓WT1基因表达，根据其表达水平分为WT1+和WT1-两组，分析两组患者的临床特点和预后。.147例MDS患者WT1+率为82.3%。WT1+和WT1-两组患者的骨髓原始细胞比例、异常染色体核型、WHO 2016分型及IPSS-R危险分层差异均有统计学意义（均P<0.05）；MDS亚型恶性程度及IPSS-R危险分层越高，WT1表达水平越高。WT1+和WT1-两组患者中位OS、进展为白血病时间差异均无统计学意义（均P>0.05）。在未移植患者中，WT1+患者中位OS较WT1-患者显著缩短（P=0.049）。WT1+移植患者预后明显优于去甲基化治疗患者（P=0.002），且死亡率低（P=0.005）。.WT1基因表达水平可用于评估MDS患者病情，与MDS患者预后密切相关。.

Clinical Significance

10.19746/j.cnki.issn.1009-2137.2022.05.030

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Increased EBV Infection and Relapse Rates Following Haploidentical Hematopoietic Cell Transplantation in the Era of Letermovir for Cytomegalovirus Prophylaxis: A Propensity Score Matching Analysis

Blood (2024)

Yifei Huang Ren Lin Shanyu Zhang Zhiping Fan Fen Huang

Cytomegalovirus

10.1182/blood-2024-202355

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A chest CT-based nomogram for predicting survival in acute myeloid leukemia

BMC Cancer (2024)

Xiaoping Yi Huien Zhan Jun Lyu Juan Du Min Dai

Abstract Background The identification of survival predictors is crucial for early intervention to improve outcome in acute myeloid leukemia (AML). This study aim to identify chest computed tomography (CT)-derived features to predict prognosis for acute myeloid leukemia (AML). Methods 952 patients with pathologically-confirmed AML were retrospectively enrolled between 2010 and 2020. CT-derived features (including body composition and subcutaneous fat features), were obtained from the initial chest CT images and were used to build models to predict the prognosis. A CT-derived MSF nomogram was constructed using multivariate Cox regression incorporating CT-based features. The performance of the prediction models was assessed with discrimination, calibration, decision curves and improvements. Results Three CT-derived features, including myosarcopenia, spleen_CTV, and SF_CTV (MSF) were identified as the independent predictors for prognosis in AML ( P < 0.01). A CT-MSF nomogram showed a performance with AUCs of 0.717, 0.794, 0.796 and 0.792 for predicting the 1-, 2-, 3-, and 5-year overall survival (OS) probabilities in the validation cohort, which were significantly higher than the ELN risk model. Moreover, a new MSN stratification system (MSF nomogram plus ELN risk model) could stratify patients into new high, intermediate and low risk group. Patients with high MSN risk may benefit from intensive treatment ( P = 0.0011). Conclusions In summary, the chest CT-MSF nomogram, integrating myosarcopenia, spleen_CTV, and SF_CTV features, could be used to predict prognosis of AML.

Nomogram

10.1186/s12885-024-12188-8

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Characterization of Polysaccharides Extracted from Sargassum fusiforme and Its Effective Prevention of Contrast-Induced Nephropathy via Enhancing Antioxidant Capacity

International Journal of Polymer Science (2019)

Min Dai Yingling Zhou Tao Jiang Caidong Luo Hu Wang

Contrast-induced nephropathy (CIN) is a common complication in patients with coronary arteriography, and oxidative stress is involved in the CIN pathogenesis. Sargassum fusiforme (SF) is a brown seaweed with medicinal value, and its polysaccharides have good antioxidant activity. In this study, the crude polysaccharides (cSFP-C) were extracted by cold water, precipitated by ethanol, purified by CaCl 2 , and detected with high contents of sulfate radical and fucose. cSFP-C is composed of glucose, glucuronic acid, xylose, rhamnose, mannose, galactose, and fucose with a molar ratio of 1.0 : 0.4 : 5.6 : 1.2 : 1.7 : 12.3 : 56.1. The cSFP-C has the typical absorption of polysaccharides. Antioxidation assays in vitro showed that cSFP-C exhibited superoxide radical scavenging activity which was better than the hot water-extracted crude polysaccharides (cSFP-H). 20 rats were divided into 4 groups (n=5): sham group; CIN group; CIN+cSFP-C group, and cSFP-C group. The CIN+cSFP-C group and cSFP-C group were pretreated intragastrically with cSFP-C at a dose of 9.45 g/kg twice daily for 5 consecutive days. Then, the CIN group and CIN+cSFP-C group were given indomethacin to develop CIN. The in vivo results showed that cSFP-C could decrease blood creatinine and urea nitrogen, inhibiting pathological injury in the renal tissues. The MDA content of renal tissues was decreased, while the activity of SOD was increased. The crude sulfated polysaccharides extracted from S. fusiforme have a renoprotective effect on oxidative stress to alleviate the kidney injury in CIN rats.

Rhamnose

Hydroxyl radical

10.1155/2019/9035818

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Citations (7)

Literature Review: Potensi Aktivitas Antikanker Bangle Hantu (Zingiber ottensii Val.)

Wahyu Eki Lailatul Azizah Min Dai

Zingiber ottensii Val. (bangle hantu) is a member of the Zingiberaceae family which has pharmacological effects such as antibody, antipyretic, anti-inflammatory, anti-neolpasmic, immunomodulatory, and anti-cancer. This review was prepared in order to determine the anti-cancer activity of the ghost bangle (Zingiber ottensii Val.) And the mechanism of action of secondary metabolites isolated from the ghost bangle. The preparation of this review was sourced from articles obtained through the PubMed and Google Schoolar database with keywords namely bangle hantu or Zingiber ottensi (Val.); cancer or sarcoma or carcinoma. The inclusion criteria used were original articles or full text research articles about the potential anticancer activity of ghosts (Zingiber ottensii Val.) With the publication year 2011-2020. Based on these criteria, 4 suitable articles were obtained. The analysis showed that there was anticancer activity obtained from cysteine protease isolates and also metabolites produced from the extraction of ghost bangle. The most abundant metabolites contained are zerumbone and 1,4-terpineol which are known to have anticancer activity in different cancer cells with healing targets in the following mechanisms: (1) induction of apoptosis, (2) anti-angiogensis, and (3) inhibition of the cell cycle.

Zingiberaceae

Zingiber officinale

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Dexmedetomidine Alleviates Abdominal Aortic Aneurysm by Activating Autophagy Via AMPK/mTOR Pathway

Cardiovascular Drugs and Therapy (2023)

Qi Yu Simin Zeng Ruilin Hu Muqi Li Qiang Liu

Sirolimus

10.1007/s10557-023-07483-8

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Citations (4)

Molecular Biomarker Analyses for Exploring the Therapeutic Mechanism of Lemzoparlimab and Azacitidine (AZA) in Newly Diagnosed Higher Risk Myelodysplastic Syndrome (HR-MDS)

Blood (2022)

Zhijian Xiao Chunkang Chang Qiubai Li Xiaojing Yan Tiejun Qin

Azacitidine

Decitabine

10.1182/blood-2022-163880

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[Preliminary Investigation of Medicinal Plant Resources in Kangle County, Gansu Province].

PubMed (2015)

Xiao-bing Ma Shihu Zhang L Jiang Min Dai Yan-Fei Jiang

To study the medicinal plant resources and their diversity in Kangle County, Gansu Province, and to provide scientific basis on utilization and protection of the medicinal plant resources of the county.By field survey, sample collection, taxonomic identification and data verification methods.There were 258 species, 65 families in existing medicinal plants, of which 43 species, 39 genera and 24 families were national protection medicinal plants. Dominant families were mainly Asteraceae and Rosaceae. In this area,the plants used whole herbs and roots ( or rhizomes) as medicinal materials represented 40.31% and 25.19% respectively, and antipyretic and rheumatism medicine accounted for 28.68% and 12.79% respectively. 12 medicinal plants were cultivated and the cultivated area was 3,000 hectares.However, the reserves of most medicinal plants are less enough and the resources are diminishing increasingly in recent years. So we should accelerate the research progress as well as developing and utilizing rationally on the premise of protection.

Ethnobotany

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Kajian Literatur: Uji Aktivitas Antioksidan Antosianin In Vitro

Mohammad Farid Alfaridzi Min Dai

Anthocyanin is a substance that is abundant in nature. This compound has a core structure of anthocyanidin that is bound to one or more glycosidic clusters like glucose. Anthocyanin has many health benefits, one of which is antioxidant. The results of research publications suggest that antioxidant activities of anthocyanin greatly exceed vitamins C and trolox. The purpose of this research is to compare and understand the extent of antioxidant activity which is held by anthocyanin compound in vitro test from multiple references. The research is a literature review of various articles according to the inclusion and exclusion criteria collected from pubMed and Google scholardatabase. Research has shown that anthocyanin has a good antioxidant activity through free radical scavenger mechanism and metal ion reduction. Such activity is affected by structure formations and clusters such as hydroxyl and catechol structures on rings A and B and clusters 3-OH on ring C. The increased of sugar substituent has a small effect on antioxidant activity of anthocyanin, while alkylation and acetylation clusters have a fixed position of C5, C7, C8, lowering its antioxidant activity. Some monomers such as cyanidin-3-O-galactoside, delphinidin-3-O-rutinoside, malvidin-3-O-glucoside, cyanidin-3-O-glucoside, cyanidin-3-O-b-D-(6-(E)-coumaroyl) glucopyranoside, and peonidin-3-caffeoyl-p-hydroxy benzoyl sophoroside-5-glucoside are known to contribute well to antioxidal activity.

Anthocyanidins

Trolox

Peonidin

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