Teresa Garrido

Instituto de Biomedicina y Genética Molecular de Valladolid

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Josep Fraile

Agencia Catalana de L'Aigua

Miguel Vicente

Centro Nacional de Biotecnología

Antoni Ginebreda

Consejo Superior de Investigaciones Científicas

Martí Aldea

Institut de Biologia Molecular de Barcelona

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‪Damià Barceló

University of Almería

Jesús Plá

Universidad Complutense de Madrid

Antoni Munné

Agencia Catalana de L'Aigua

Josep Sanchís

Agencia Catalana de L'Aigua

Marinella Farré

Institute of Environmental Assessment and Water Research

Fernando Rubio

Abraxis (United States)

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Consejo Superior de Investigaciones Científicas

Universitat de Barcelona

Institute of Environmental Assessment and Water Research

Universitat Politècnica de Catalunya

Instituto de Salud Carlos III

Universidade de São Paulo

Hospital Clínic de Barcelona

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

University of Girona

Hospital de São João

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Advances in the pathophysiology of primary immune thrombocytopenia

Hematology (2016)

María Perera Teresa Garrido

Classically, immune thrombocytopenia (ITP) was thought to be caused by the destruction and insufficient production of platelets, as mediated by autoantibodies. More recently other immune mechanisms that contribute to the disease have been discovered. This review attempts to address the main unresolved questions in ITP.We review the most current knowledge of the pathophysiology of ITP. Immunological effects of available therapies are also described.The trigger may be a loss of tolerance due to molecular mimicry with cross-reaction of antibodies arising from infectious agents or drugs, genetic factors, and/or platelet Toll receptors. This loss of tolerance activates autoreactive effector B and T lymphocytes, which in turn initiates platelet destruction, mediated by cytotoxic T lymphocytes and the release of pro-inflammatory cytokines (IL-2/IL-17) by T helper (Th) cells (Th1/Th17). Th2 (anti-inflammatory) and regulatory B (Breg) and Treg cells are also inhibited (with decrease in IL-10/TGF-β), which leads to the disease becoming chronic. Some isotypes of autoantibodies may increase the bleeding risk. Corticosteroids, rituximab, and thrombopoietin receptor agonists (A-TPOs) all increase levels of Tregs and TGF-β. The A-TPOs also increase Breg levels, which could explain why complete remission has been seen in some cases.A better understanding of the immunomodulatory effects of each ITP therapy is needed to best manage the disease.

Molecular mimicry

Pathophysiology

10.1080/10245332.2016.1219497

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Citations (60)

Four-year advanced monitoring program of polar pesticides in groundwater of Catalonia (NE-Spain)

The Science of The Total Environment (2013)

Marianne Köck-Schulmeyer Antoni Ginebreda Cristina Postigo Teresa Garrido Josep Fraile

10.1016/j.scitotenv.2013.10.079

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Citations (104)

Endobronchial Ultrasound Application for Diagnosis of Tracheobronchial Tree Invasion by Esophageal Cancer

Clinics (2009)

Teresa Garrido Fauze Maluf‐Filho Rubens Antônio Aissar Sallum Vivíane Rossi Figueiredo Márcia Jacomelli

Esophageal cancer staging has been performed through bronchoscopy, computerized tomography (CT), positron emission tomography (PET), and endoscopic ultrasound (EUS). Whereas CT and PET scan provide assessments of distant metastasis, bronchoscopy importantly diagnoses tracheobronchial involvement, complementing chest CT findings. EUS is the most accurate examination for T and N staging but is technically limited when tumoral stenoses cannot be traversed. Endobronchial ultrasound (EBUS) appears to present greater accuracy than EUS, CT, and bronchoscopy for assessing tracheobronchial wall involvement. EBUS has been recently associated with EUS for esophageal cancer staging in our unit.To compare EBUS findings in esophageal cancer patients without evident signs of tracheobronchial invasion on conventional bronchoscopy with EUS and CT.Fourteen patients with esophageal cancer underwent CT, conventional bronchoscopy, EUS, and EBUS for preoperative staging. All patients underwent EBUS and EUS with an Olympus(R) MH-908 echoendoscope at 7.5 MHz. Seven patients were eligible for the study according to the inclusion criteria.The echoendoscope could not traverse tumoral esophageal stenosis to perform EUS in two patients, and invasion was effectively diagnosed by EBUS. In 4 (57%) of 7 patients EBUS revealed additional information to staging. In the remaining 3 cases the invasion findings were the same under both EUS and EBUS.EBUS showed signs of tracheobronchial invasion not observed by conventional bronchoscopy, adding information to staging in most of the cases when compared with CT and EUS.

Endoscopic Ultrasound

10.1590/s1807-59322009000600003

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Citations (15)

Gearbox gene expression and growth rate

World Journal of Microbiology and Biotechnology (1993)

Martí Aldea Teresa Garrido Antonio Tormo

rpoS

Regulon

Transcription

Sigma factor

10.1007/bf00328029

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Trend Assessment for Groundwater Pollutants: A Brief Review and Some Remarks

The handbook of environmental chemistry (2015)

Francesc Oliva Esteban Vegas Sergi Civit Teresa Garrido Josep Fraile

Water Framework Directive

Groundwater Pollution

10.1007/698_2015_407

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Citations (5)

GIS-based hydrogeochemical analysis tools (QUIMET)

Computers & Geosciences (2014)

V. Velasco Isabel Tubau Enric Vázquez‐Suñé Constantin Radu Gogu Dragoş Găitănaru

Univariate

Statistic

10.1016/j.cageo.2014.04.013

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Citations (29)

Rapid Movement of Palmitoleic Acid from Phosphatidylcholine to Phosphatidylinositol in Activated Human Monocytes

Biomolecules (2024)

Miguel A. Bermúdez Alvaro Garrido Laura Pereira Teresa Garrido Marı́a A. Balboa

This work describes a novel route for phospholipid fatty acid remodeling involving the monounsaturated fatty acid palmitoleic acid. When administered to human monocytes, palmitoleic acid rapidly incorporates into membrane phospholipids, notably into phosphatidylcholine (PC). In resting cells, palmitoleic acid remains within the phospholipid pools where it was initially incorporated, showing no further movement. However, stimulation of the human monocytes with either receptor-directed (opsonized zymosan) or soluble (calcium ionophore A23187) agonists results in the rapid transfer of palmitoleic acid moieties from PC to phosphatidylinositol (PI). This is due to the activation of a coenzyme A-dependent remodeling route involving two different phospholipase A2 enzymes that act on different substrates to generate free palmitoleic acid and lysoPI acceptors. The stimulated enrichment of specific PI molecular species with palmitoleic acid unveils a hitherto-unrecognized pathway for lipid turnover in human monocytes which may play a role in regulating lipid signaling during innate immune activation.

Palmitoleic acid

10.3390/biom14060707

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Citations (1)

[Study of a family with osteogenesis imperfecta].

PubMed (1969)

J.M.Romeo Orbegozo Teresa Garrido Fiona Martin M. González Molina A. Quintana Castilla

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Citations (1)

Association Between Uric Acid Levels and Severe Acute Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation

Blood (2015)