J Kvĕtina

University Hospital Hradec Králové

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jan Bureš

Charles University

Martin Kuneš

University Hospital Hradec Králové

Marcela Kopáčová

University Hospital Hradec Králové

Stanislav Rejchrt

University Hospital Hradec Králové

Ilja Tachecí

Charles University

Zbyněk Svoboda

PRO.MED.CS Praha (Czechia)

Milan Nobilis

Charles University

Milan Lázníček

Charles University

VŠ

V. Štětinová

Czech Academy of Sciences

Michal Pavlík

University of Veterinary Sciences Brno

Cooperative Institutions

Charles University

128

University Hospital Hradec Králové

University of Hradec Králové

Czech Academy of Sciences

PRO.MED.CS Praha (Czechia)

University of Defence

Masaryk University

Institute of Pharmacology

Vall d'Hebron Hospital Universitari

Ocní klinika

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

A Versatile Method for the <i>in vitro</i> Perfusion of Isolated Organs of Rats and Mice with Particular Reference to Liver

Pharmacology (1969)

J Kvĕtina A. Guaitani

10.1159/000136003

Cite

Citations (43)

Effect of plasma binding of ortho- and para-I-benzoates on their distribution in blood and into lymph, biotransformation and excretion in rat urine

European Journal of Drug Metabolism and Pharmacokinetics (1993)

J. Lamka Milan Lázníček Š Gallová L Rudisar J Kvĕtina

Benzoates

10.1007/bf03188801

Cite

Citations (2)

Miotic action of tramadol is determined by CYP2D6 genotype

Physiological Research (2007)

Ondřej Slanař Milan Nobilis J Kvĕtina R Mikoviny Tomáš Zima

Polymorphic CYP2D6 is the enzyme that activates the opioid analgesic tramadol by O-demethylation to its active metabolite O-demethyltramadol (M1). Our objective was to determine the opioid effects measured by pupillary response to tramadol of CYP2D6 genotyped volunteers in relation to the disposition of tramadol and M1 in plasma. Tramadol displayed phenotypic pharmacokinetics and it was possible to identify poor metabolizers (PM) with >99% confidence from the metabolic ratio (MR) in a single blood sample taken between 2.5 and 24 h post-dose. Homozygous extensive metabolizers (EM) differed from PM subjects by an almost threefold greater (P=0.0014) maximal pupillary constriction (Emax). Significant correlations between the AUC and Cmax values of M1 versus pupillary constriction were found. The corresponding correlations of pharmacokinetic parameters for tramadol itself were weaker and negative. The strongest correlations were for the single-point metabolic ratios at all sampling intervals versus the effects, with rs ranging from 0.85 to 0.89 (p<0.01). It is concluded that the concept of dual opioid/non-opioid action of the drug, though considerably stronger in EMs, is valid for both EM and PM subjects. This is the theoretical basis for the frequent use and satisfactory efficacy of tramadol in clinical practice when given to genetically non-selected population.

Active metabolite

10.33549/physiolres.930872

Cite

Citations (39)

The pharmacokinetics of intraduodenally administered diazepam in rats as influenced by composition of the central lymph.

PubMed (1989)

J. Lamka O Jindrová L Rudisar P Kohoutek Š Gallová

Diazepam, a drug with hydrophobic properties, was used as a model for studying its distribution (after intraduodenal administration) into the central lymph of rats. The intestinal lymph, which prevails in the central lymph, was modified for the presence of total lipids (chylomicrons) by means of fasting, a normal or an artificial diet (olive oil). The lymphatic levels of diazepam exceeded the corresponding blood levels in the fed and oil-fed group; the levels were steady in the fasted group with the exception of the absorption phase of the curves. The kinetic parameters assessed in the blood and lymph of the individual groups obtained by mathematical evaluation of the concentration curves differed because of quantitative differences in the presence of chylomicrons in the lymph. Lymphatic bioavailability in comparison with i.v. administration was found to be substantially lower.

Chylomicron

Source

Cite

Citations (1)

14CH3-N-pethidine biotransformation in the rat and rabbit isolated perfused liver during the pathological process.

PubMed (1975)

J Kvĕtina

The demonstration of decreased hydrolysis and demethylation of pethidine in the liver subcellular fractions in the course of acute radiation sickness was not verified under the conditions of perfusion of the isolated liver. An attempt was made to interpret the discrepancy in the findings by a change in the intensity of uptake of pethidine and its metabolites in liver tissue after irradiation.

Pethidine

Demethylation

Biotransformation

Source

Cite

Citations (0)

[Comparison of the binding of nitrazepam and diazepam to erythrocytes in selected mammalian species].

PubMed (1984)

J Lamka Milan Lázníček J Kvĕtina

Nitrazepam

Source

Cite

Citations (0)

Changes in motility, secretion, and resorption in the digestive tract of irradiated rats

V. Grossmann V Chmelar J Kvĕtina

Digestive tract

Source

Cite

Citations (0)

TO THE QUESTION OF CHANGED EFFECT OF d-TUBOCURARINE IN IRRADIATED ANIMALS.

V. Grossmann J Kvĕtina O. Peca Hyunh Thanh

D-Tubocurarine

Source

Cite

Citations (0)

INFLUENCE OF IRRADIATION OF THE WHOLE BODY ON THE DISTRIBUTION OF PETHIDINE AND NORPETHIDINE IN THE ORGANISM OF RATS

J Kvĕtina J. Cellerova

The level of pethidine in the blood of irradiated rats was higher than in nonirradiated ones, but lower in the brain. Similar results were obtained with norpethidine. (OTS)

Pethidine

Whole body irradiation

Source

Cite

Citations (0)

Correction: The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs

PLoS ONE (2024)

Chrysostomi Christina Tsianou J Kvĕtina Věra Radochová Darina Kohoutová Stanislav Rejchrt

[This corrects the article DOI: 10.1371/journal.pone.0286386.].

Rivastigmine

Correct name

10.1371/journal.pone.0315834

Cite

Citations (0)