Mahsa Ale‐Ebrahim

Islamic Azad University Medical Branch of Tehran

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Pejman Mortazavi

Islamic Azad University, Science and Research Branch

Mojtaba Falahati

Erasmus MC

Keivan Akhtari

University of Kurdistan

Majid Sharifi

Shahroud University of Medical Sciences

Anwarul Hasan

Qatar University

Behnam Rasti

Islamic Azad University, Lahijan Branch

Koorosh Shahpasand

Royan Institute

Mojtaba Falahati

Erasmus MC Cancer Institute

Abbas Salihi

Salahaddin University-Erbil

Mohammad Mahdi Nejadi Babadaei

Islamic Azad University North Tehran Branch

Cooperative Institutions

Islamic Azad University Medical Branch of Tehran

Tehran University of Medical Sciences

Islamic Azad University Pharmaceutical Sciences Branch

Islamic Azad University, Tehran

University of Tehran

Islamic Azad University, Science and Research Branch

Shahid Beheshti University of Medical Sciences

Islamic Azad University, Lahijan Branch

Iran University of Medical Sciences

Academic Center for Education, Culture and Research

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Tau folding and cytotoxicity of neuroblastoma cells in the presence of manganese oxide nanoparticles: Biophysical, molecular dynamics, cellular, and molecular studies

International Journal of Biological Macromolecules (2018)

Parvaneh Mehdizadeh Samaneh Sadat Hashemi Fesharaki Mina Nouri Mahsa Ale‐Ebrahim Keivan Akhtari

Viability assay

SH-SY5Y

Docking (animal)

10.1016/j.ijbiomac.2018.11.191

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Citations (17)

Morphine exposure before conception affects anxiety-like behavior and CRF level (in the CSF and plasma) in the adult male offspring

Brain Research Bulletin (2018)

Saba Sabzevari Kiyana Rohbani Mitra‐Sadat Sadat‐Shirazi Nima Babhadi‐Ashar Atena Shakeri

Elevated plus maze

10.1016/j.brainresbull.2018.11.022

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Citations (27)

Atheroprotective and hepatoprotective effects of trans-chalcone through modification of eNOS/AMPK/KLF-2 pathway and regulation of COX-2, Ang-II, and PDGF mRNA expression in NMRI mice fed HCD

Molecular Biology Reports (2022)

Mahsa Ale‐Ebrahim Raziyeh Rahmani Kousar Faryabi Niloofar Mohammadifar Pejman Mortazavi

Chalcone

10.1007/s11033-022-07174-x

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Citations (7)

The effects of nickel oxide nanoparticles on structural changes, heme degradation, aggregation of hemoglobin and expression of apoptotic genes in lymphocytes

Journal of Biomolecular Structure and Dynamics (2019)

Niusha Abbasi Gamasaee Hawzheen A. Muhammad Elahe Tadayon Mahsa Ale‐Ebrahim Mirsasan Mirpour

Nickel oxide nanoparticles (NiO NPs) have received great interests in medical and biotechnological applications. However, their adverse impacts against biological systems have not been well-explored. Herein, the influence of NiO NPs on structural changes, heme degradation and aggregation of hemoglobin (Hb) was evaluated by UV-visible (Vis) spectroscopy, circular dichroism (CD) spectroscopy, fluorescence spectroscopy, transmission electron microscopy (TEM), and molecular modeling investigations. Also, the morphological changes and expression of Bax/Bcl-2 mRNA in human lymphocyte cell exposed to NiO NPs were assayed by DAPI staining and quantitative real-time PCR (qPCR), respectively. The UV-Vis study depicted that NiO NPs resulted in the displacement of aromatic residues and heme groups and production of the pro-aggregatory species. Intrinsic and Thioflavin T (ThT) fluorescence studies revealed that NiO NPs resulted in heme degradation and amorphous aggregation of Hb, respectively, which the latter result was also confirmed by TEM study. Moreover, far UV-CD study depicted that NiO NPs lead to substantial secondary structural changes of Hb. Furthermore, near UV-CD displayed that NiO NPs cause quaternary conformational changes of Hb as well as heme displacement. Molecular modelling study also approved that NiO NPs resulted in structural alterations of Hb and heme deformation. Moreover, morphological and genotoxicity assays revealed that the DNA fragmentation and expression ratio of Bax/Bcl-2 mRNA increased in lymphocyte cells treated with NiO NPs for 24 hr. In conclusion, this study indicates that NiO NPs may affect the biological media and their applications should be limited.Communicated by Ramaswamy H. Sarma.

Non-blocking I/O

Hemeprotein

10.1080/07391102.2019.1662850

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Citations (15)

Antioxidant properties of gold nanozyme: A review

Journal of Molecular Liquids (2019)

Majid Sharifi Kousar Faryabi Amir Jouya Talaei Mudhir Sabir Shekha Mahsa Ale‐Ebrahim

10.1016/j.molliq.2019.112004

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Citations (87)

Simultaneous Treatment with P53 Overexpression and Interferon Î³ Exerts a Dramatic Increase in Apoptosis Induction of U87 Cells

Galen Medical Journal (2023)

Zahra Abbasy Hamid Zaferani Arani Mahsa Ale‐Ebrahim Vihan Moodi Javad Nematian

Background: Gliomas possess low immunogenicity, which is an inevitable hinder in front of cancer immunotherapy. Different interferons (IFNs) may proceed apoptosis instead in p53-dependent or independent pathways. P53 induces the anti-inflammatory programmed cell death in cancer cells; on the other hand, IFN gamma (IFNÎ³) is a modulatory/pro-inflammatory cytokine. There are contradictory reports of whether this cytokine can possess an anti- or pro-cancerous impact on tumors. Hence, we aimed to investigate the possible cooperative apoptotic effect of the P53 and IFNÎ³ over expressions on the U87 glioblastoma cell line. Materials and Methods: The P53 expressing vector was amplified by Escherichia coli BL21. This vector was confirmed by the aid of sequencing. At the next step, U87 cells were transfected using lipofectamine. Cells were treated with P53 vector and/or IFNÎ³. The type of cellular death investigated by flow cytometry and the expression level of cleaved caspase-3 protein was also precisely demonstrated by western blotting. Results: Sequencing results revealed that inserted P53 was identical with human P53. Western blot results revealed that both IFNÎ³ and P53 overexpression could up-regulate cleaved caspase-3 protein expression in this cell line. Interestingly, flow cytometry data determined that concurrent treatment with P53 exogenous overexpression and IFNÎ³ induces about 70% apoptosis in U87; more than the sum of cell death occurs after IFNÎ³ or P53 overexpression alone (~18%+21%=39%). Conclusion: The present study results showed that p53-overexpression and IFNÎ³ could ultimately induce up-regulation of the caspase-3 and ultimately significant apoptosis increasing in the U87 cell line. Although IFNÎ³ is believed to be a pro-inflammatory cytokine and P53 is an anti-inflammatory agent, our results demonstrated that they could act synergistically to induce apoptosis in U87 cells. [GMJ.2021;10:e2270]

Lipofectamine

10.31661/gmj.v10i.2270

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Polymeric micelles functionalized with cell penetrating peptides as potential pH-sensitive platforms in drug delivery for cancer therapy: A review

Arabian Journal of Chemistry (2021)

Suliman Khan Yasaman Vahdani Arif Hussain Setareh Haghighat Fatemeh Heidari

Improving the intrinsic pharmacodynamics or pharmacokinetic of drugs is regarded as a crucial step in developing potential drug therapies. In this context, the development of nanostructured-based drug delivery systems (DDSs) responsive to exogenous or endogenous stimuli demonstrate an outstanding platform to clinical applications. Polymeric micelles (PM)-based DDSs are often modified with selective short peptides like cell penetrating peptides (CPPs) for highly efficient cellular internalization. In this review, we discussed recent achievements in the design and development of nanoscale pH-responsive micelles modified with CPPs to provide controlled drug release in the tumor cells. An overview on the application of micelles, especially PMs as promising engineered nanocarriers to combine pharmaceutical agents with CPPs are presented. Afterwards, the peptide-based transfection method as one of the promising approaches for drug delivery and therapeutic agents was explained. Subsequently, conjugation of pH-responsive micelles with CPPs as a novel DDS in cancer therapy was surveyed. Finally, the current challenges and future application of stimuli-sensitive nanoplatforms conjugated with CPP were discussed. In conclusion, the application of controlled delivery using pH-sensitive PMs-based DDSs conjugated with peptides can be considered as a potential approach to improve the therapeutic index of anticancer drugs.

Nanocarriers

Cancer Therapy

Internalization

10.1016/j.arabjc.2021.103264

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Citations (26)

Hydrothermal method-based synthesized tin oxide nanoparticles: Albumin binding and antiproliferative activity against K562 cells

Materials Science and Engineering C (2020)

Leila Ebrahimi Ahmadabad Firoozeh Samia Kalantari Hui Liu Anwarul Hasan Niusha Abbasi Gamasaee

Human serum albumin

Zeta potential

Nanoclusters