Beatriz Gómez‐Ansón

Hospital de Sant Pau

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Yolanda Vives‐Gilabert

Universitat de València

Jaime Kulisevsky

Universitat Autònoma de Barcelona

Javier Pagonabarraga

Biomedical Research Networking Center on Neurodegenerative Diseases

Saül Martínez‐Horta

Hospital de Sant Pau

Frederic Sampedro

Hospital de Sant Pau

Jesús Pérez‐Pérez

Hospital de Sant Pau

José Luís Molinuevo

Pasqual Maragall Foundation

Andrea Horta‐Barba

Hospital de Sant Pau

Gemma C. Monté

Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol

Lorena Rami

Hospital Clínic de Barcelona

Cooperative Institutions

Hospital de Sant Pau

242

Universitat Autònoma de Barcelona

178

University College London

160

Biomedical Research Institute

115

Instituto de Salud Carlos III

113

Centro de Investigación Biomédica en Red

106

Universitat de Barcelona

National Hospital for Neurology and Neurosurgery

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Biomedical Research Networking Center on Neurodegenerative Diseases

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P2-132: BIOMARKERS IN CEREBRAL AMYLOID ANGIOPATHY-RELATED INFLAMMATION

Alzheimer s & Dementia (2014)

María Carmona‐Iragui Ana Fernández‐Arcos Daniel Alcolea Fabrizio Piazza Estrella Morenas‐Rodríguez

Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare meningoencephalitis that presents with focal neurological deficits, cortical microbleeds and asymmetrical white matter lesions, usually steroid-responsive. It shares radiological features with amyloid related imaging abnormalities (ARIA), described in Alzheimer's disease (AD) patients that receive antiamyloid therapies, suggesting a common pathophysiological process. Clinical, neuropsychological and radiological description; APOE genotyping and cerebrospinal fluid (CSF) biomarkers (Aβ 42, Aβ 40, t-Tau, p-Tau and anti-A b autoantibodies) were determined in four patients with probable CAA-ri. PET imaging with Florbetapir was performed in two subjects, and one of them had a PET-PIB additionally. Patients received steroids and were clinically evaluated. T hree patients had imaging and CSF follow-up. Mean age of presentation was 73.5 years (range 69-78), 50% were men. All patients presented with neurological focal symptoms and cognitive impairment. MRI showed cortical microbleeds and asymmetrical hyperintense white matter lesions. Allelic frequency for APOE-e4 was 62.5%. Aß40 and Aß42 levels were decreased and anti-Ab autoantibodies were high in all cases. A PET with Florbetapir, performed in two patients, and a PET-PIB performed in one of them, showed cortical amyloid deposits. After corticosteroid administration, a complete (1/4) or partial (3/4) resolution of focal symptoms was observed. One patient suffered an intracerebral lobar hemorrhage six months after the resolution of focal symptoms. On the follow-up MRI, a significant reduction of white matter lesions was appreciated. CSF anti-Ab autoantibodies at follow-up were markedly reduced in all cases. The pattern in CSF and amyloid PET biomarkers and the presence of APOE-e4 in CAA-ri suggests an important role of vascular amyloidosis. Anti-Ab autoantibodies may be a specific biomarker for this process, and could be useful for CAA-ri diagnosis and monitoring the response to treatment.

Neuroradiology

Pathophysiology

10.1016/j.jalz.2014.05.807

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Citations (1)

Measuring impulsivity in Parkinson’s disease: a correlational and structural neuroimaging study using different tests

European Journal of Neurology (2020)

Juan Marín‐Lahoz Saül Martínez‐Horta Frederic Sampedro Javier Pagonabarraga Andrea Horta‐Barba

Impulsivity is an aspect of personality and a major component of multiple neuropsychiatric conditions. In Parkinson's disease, it has been associated with the expression of impulse control disorders, a highly prevalent non-motor complication. Even though multiple tests of impulsivity have been used in this context, the impact of test choice has not been addressed. The aim was to evaluate whether different impulsivity measures in Parkinson's disease share substantial inter-scale and anatomical correlations or rather mirror different underlying phenomena.In a consecutive sample of 89 Parkinson's disease patients without impulse control disorders, four common tests were evaluated assessing different aspects of impulsivity: impulsiveness trait, decisions under implicit risk with and without losses, and delay discounting. Correlations among test scores were analysed and each score was used as a regressor in a set of grey matter volume (GMV) voxel-based morphometry analyses to explore their brain structural correlates.No significant correlations were found between the different impulsivity tests. Furthermore, their structural brain correlates were divergent. Impulsiveness trait appeared to be associated with lower GMV in dorsal-lateral prefrontal cortices, implicit risk (with losses) with higher GMV in the left nucleus accumbens and lower left insular GMV, implicit risk (without losses) with higher GMV in the left lingual gyrus and lower GMV in the gyri recti and delay discounting with higher GMV in the left nucleus accumbens.In Parkinson's disease, different impulsivity measures reflect very dissimilar behavioural and brain structural correlates. Our results suggest that parkinsonian impulsivity is not a unitary phenomenon but rather a heterogeneous entity.

10.1111/ene.14235

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Citations (7)

Cerebral magnetic resonance imaging reveals marked abnormalities of brain tissue density in patients with cirrhosis without overt hepatic encephalopathy

Journal of Hepatology (2010)

Mónica Guevara María E. Baccaro Beatriz Gómez‐Ansón Giovanni B. Frisoni Cristina Testa

Hepatic Encephalopathy

10.1016/j.jhep.2010.12.008

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Citations (98)

Antibodies against the flotillin-1/2 complex in patients with multiple sclerosis

medRxiv (Cold Spring Harbor Laboratory) (2022)

Cinta Lleixà Marta Caballero‐Ávila Elba Pascual‐Goñi L. Aguilar Núria Vidal

ABSTRACT Multiple sclerosis (MS) is a tissue-specific autoimmune disease of the central nervous system in which the antigen(s) remains elusive. Antibodies targeting the flotillin-1/2 (FLOT–1/2) complex have been described in 1-2% of the patients in a recent study. Other candidate antigens as anoctamin-2 (ANO2) or neurofascin-155 (NF155) have been previously described in MS patients, although their clinical relevance remains uncertain. Our study aims to analyse the frequency and clinical relevance of antibodies against NF155, ANO2 and the FLOT-1/2 complex in MS. Serum (n=252) and CSF (n=50) samples from 282 MS patients were included in the study. The control group was composed of 260 serum samples (71 healthy donors and 189 with other neuroinflammatory disorders). Anti-FLOT1/2, anti-ANO2 and anti-NF155 antibodies were tested by cell-based assays using transfected-HEK293 cells. We identified 6 MS patients with antibodies against the FLOT-1/2 complex (2.1%) and 1 MS patient with antibodies against ANO2 (0.35%). All MS patients were negative for anti-NF155 antibodies. Three of the anti-FLOT1/2 positive patients showed anti-FLOT-1/2 positivity in other serum samples extracted at different moments of their disease. IgG subclasses of anti-FLOT-1/2 antibodies were predominantly IgG1 and IgG3. We confirm that antibodies targeting the Flotillin-1/2 complex are present in a subgroup of patients with MS. Further studies are needed to understand the clinical and pathological relevance of anti-FLOT-1/2 autoantibodies in MS.

Clinical Significance

10.1101/2022.09.14.22278529

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Citations (0)

The usefulness of 18 F-fluorocholine PET/CT in the detection of recurrence of central nervous system primary neoplasms

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) (2017)

A. Montes Alberto Fernández Valle Camacho C. de Quintana Óscar Gallego

10.1016/j.remnie.2017.03.001

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Citations (3)

Small Vessel Disease

Clinical Neuroradiology (2019)

Hans Rolf Jäger Beatriz Gómez‐Ansón

Neuroradiology

Stroke

10.1007/978-3-319-61423-6_22-1

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Citations (1)

Stroke Risk and Antithrombotic Treatment During Follow-up of Patients With Ischemic Stroke and Cortical Superficial Siderosis

Neurology (2022)

Joan Martí–Fàbregas Pol Camps‐Renom Jonathan G. Best Anna Ramos‐Pachón Marina Guasch‐Jiménez

In patients with ischemic stroke (IS) or transient ischemic attack (TIA) and cortical superficial siderosis (cSS), there are few data regarding the risk of future cerebrovascular events and also about the benefits and safety of antithrombotic drugs for secondary prevention. We investigated the associations of cSS and stroke risk in patients with recent IS or TIA.

Superficial siderosis

Stroke

Siderosis

Stroke risk

10.1212/wnl.0000000000201723

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Citations (3)

Pachymeningitis, Painful Ophthalmoplegia, and Multiple Cranial Neuropathy of Presumed Tuberculous Origin

Neuro-Ophthalmology (2011)

Marc Suárez‐Calvet Ricardo Rojas‐García Joaquín López‐Contreras Beatriz Gómez‐Ansón Carles Roig-Arnall

The authors describe a patient with persistent headache initially diagnosed as idiopathic hypertrophic pachymeningitis after a comprehensive study that included meningeal biopsy. Despite early response to corticosteroids, the headache relapsed 3 years later and he further developed painful ophthalmoplegia and multiple cranial neuropathies (V1, VI, VIII, and X). A cervical lymph node biopsy revealed caseating granulomas and antituberculous therapy was started. Symptoms had resolved at 3-month follow-up. The authors discuss tuberculosis as a possible cause of pachymeningitis, painful ophthalmoplegia, and multiple cranial neuropathy syndromes, and describe the common features of these clinical conditions.

External ophthalmoplegia

Lymph node biopsy

10.3109/01658107.2011.620215

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Citations (2)

Atypical astroglial pTDP‐43 pathology in astroglial predominant tauopathy

Neuropathology and Applied Neurobiology (2021)

Ellen Gelpí Ibán Aldecoa Dolores López‐Villegas María Teresa Abellán-Vidal Pilar Mercadel‐Fañanas

We observed atypical astrocytic pTDP-43 pathology in astroglial predominant tauopathy.

Tauopathy

10.1111/nan.12707

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