Feng Peng

Guangdong Academy of Medical Sciences

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Donghui Wang

Shandong University

Xuanyong Liu

Chinese Academy of Sciences

Dongdong Zhang

Taiyuan University of Science and Technology

Juning Xie

Guangdong Academy of Medical Sciences

Yuqin Qiao

Lanzhou University

Mei Li

Dongguan University of Technology

Shi Cheng

South China University of Technology

Feng Long

Pharmaceutical Biotechnology (Czechia)

Yu Zhang

Guangdong Academy of Medical Sciences

M. Yao

Max Planck Institute for Chemical Physics of Solids

Cooperative Institutions

Chinese Academy of Sciences

103

University of Chinese Academy of Sciences

Southern Medical University

Guangdong Academy of Medical Sciences

Guangdong Provincial People's Hospital

Shanghai Institute of Ceramics

Sun Yat-sen University

Hebei University of Technology

Peking University

Sichuan University

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A copper-metal organic framework enhances the photothermal and chemodynamic properties of polydopamine for melanoma therapy

Acta Biomaterialia (2023)

Lidan Liu Haifeng Zhang Luxi Peng Donghui Wang Yu Zhang

Photothermal effect

Nanomaterials

10.1016/j.actbio.2023.01.010

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Citations (51)

Molecular and analysis of a phenylalanine ammonia-lyase gene (LrPAL2) from Lycoris radiata

Molecular Biology Reports (2012)

Yumei Jiang Bing Xia Lijian Liang Xiaodan Li Sheng Xu

Phenylalanine ammonia-lyase

10.1007/s11033-012-2310-8

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Citations (33)

Effect of Cold Rolled-Batch Annealed on Texture and Properties of Low Carbon Strip Steel Based on CSP

Zili Jin Huiping Ren Haiyan Wang Feng Peng

With the help of electron backscatter diffraction (EBSD ) and orientation distribution function (ODF) analysis, experiments of the different batch annealing Parameters were conducted to give an study of texture of Cold-rolling Low Carbon sheet steel based on CSP, and the relationship between initial isothermal temperature and drawing properties has been investigated. Cold-rolled sheet annealing process is nearing completion of recrystallization annealing has a strong favorable texture, and then cold-rolled sheet will help ensure isothermal conducive to further improve texture. The double step isothermal batch annealing process design, enabling access to a strong favorable texture and uniform pancake grains and higher drawing properties, and the proper temperature is the key control factor level.

Recrystallization (geology)

Isothermal process

10.1109/maee.2013.19

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Zinc-doped ferric oxyhydroxide nano-layer enhances the bactericidal activity and osseointegration of a magnesium alloy through augmenting the formation of neutrophil extracellular traps

Acta Biomaterialia (2022)

Mei Li Dongdong Zhang Feng Peng Juning Xie Xianrong Zhang

10.1016/j.actbio.2022.08.066

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Citations (17)

A pH-response chemotherapy synergistic photothermal therapy for tumor suppression and bone regeneration by mussel-inspired Mg implant

Regenerative Biomaterials (2021)

Hongwei Shao Shi Cheng M. Yao Xiongfa Ji Hua Zhong

Abstract Primary malignant bone tumors can be life-threatening. Surgical resection of tumor plus chemotherapy is the standard clinical treatment. However, postoperative recovery is hindered due to tumor recurrence caused by residual tumor cells and bone defect caused by resection of tumor tissue. Herein, a multifunctional mussel-inspired film was fabricated on Mg alloy, that is, an inner hydrothermal-treated layer, a middle layer of polydopamine, and an outer layer of doxorubicin. The modified Mg alloy showed excellent photothermal effect and thermal/pH-controlled release of doxorubicin. The synergistic effect of chemotherapy and photothermal therapy enabled the modified Mg alloy to kill bone tumor in vitro and inhibit tumor growth in nude mice. Moreover, because of the controlled release of Mg ions and biocompatibility of polydopamine, the modified Mg alloy supported extracellular matrix mineralization, alkaline phosphatase activity, and bone-related gene expression in C3H10T1/2. Bone implantation model in rats verified that the modified Mg showed excellent osteointegration. These findings prove that the use of mussel-inspired multifunction film on Mg alloy offers a promising strategy for the therapy of primary malignant bone tumor.

Biocompatibility

10.1093/rb/rbab053

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Citations (13)

Two-dimensional layered double hydroxides for biomedical applications: From nano-systems to surface- and body-systems

Progress in Materials Science (2023)

Huihui Du Dongdong Zhang Feng Peng Kwk Yeung Xuanyong Liu

Layered double hydroxides

Biocompatibility

Nanomaterials

Surface Modification

Simulated body fluid

10.1016/j.pmatsci.2023.101220

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Citations (12)

Collaborative Design of MgO/FeO_x Nanosheets on Titanium: Combining Therapy with Regeneration

Small (2022)

Dongdong Zhang Ji Tan Ru Xu Huihui Du Juning Xie

Abstract The repair of bone defects caused by osteosarcoma resection remains a clinical challenge because of the tumor recurrence and bacterial infection. Combining tumor and bacterial therapy with bone regeneration properties in bone implants is a promising strategy for the treatment of osteosarcoma. Here, a layer of MgO/FeO x nanosheet is constructed on the Ti implant to prevent tumor recurrence and bacterial infection, while simultaneously accelerating bone formation. This MgO/FeO x double metal oxide demonstrates good peroxidase activity to catalyze H 2 O 2 , which is rich in tumor microenvironment, to form reactive oxygen species (ROS), and shows good photothermal conversion capacity to produce photothermal effect, thus synergistically killing tumor cells and eliminating tumor tissue. In addition, it generates a local alkaline surface microenvironment to inhibit the energy metabolism of bacteria to enhance the photothermal antibacterial effect. Furthermore, benefiting from the generation of a Mg ion‐containing alkaline microenvironment, this MgO/FeO x film can promote the osteogenic differentiation of osteoblast and angiogenesis of vascular endothelial cells in vitro as well as accelerated bone formation in vivo. This study proposes a multifunctional platform for integrating tumor and bacterial therapy and bone regeneration, which has good application prospects for the treatment of osteosarcoma.

Photothermal effect

10.1002/smll.202204852

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Citations (12)

Improved in vitro angiogenic behavior of human umbilical vein endothelial cells with oxidized polydopamine coating

Colloids and Surfaces B Biointerfaces (2020)

Shi Cheng Donghui Wang Jin Ke Limin Ma Feng Long

CD31

10.1016/j.colsurfb.2020.111176

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Citations (27)

Ferric oxide nanosheet-engineered Mg alloy for synergetic osteosarcoma photothermal/chemodynamic therapy