Qiuwen Zhang

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Hui Meng

City University

Chuan Ma

Southwest Medical University

Zhentong Zhang

Yong Li

Changchun University of Chinese Medicine

Daoan Kang

Southwestern Institute of Physics

Jingang Xiao

Affiliated Hospital of Southwest Medical University

Zhengwen Cai

Sichuan University

Maogeng Feng

Southwest Medical University

Long Bai

Renji Hospital

Dongling Geng

Civil Aviation University of China

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Southwest Medical University

Sichuan University

Chinese Academy of Sciences

Affiliated Hospital of Southwest Medical University

Stomatology Hospital

State Key Laboratory of Oral Diseases

University of Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

International Centre for Materials Physics

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Electromagnetic-wave-absorption properties of wire-like structures self-assembled by FeCo nanocapsules (vol 41, 175001, 2008)

X. G. Liu Dongling Geng Hui Meng B. Li Qiuwen Zhang

[liu, x. g.] chinese acad sci, shenyang natl lab mat sci, inst met res, shenyang 110016, peoples r china. chinese acad sci, int ctr mat phys, shenyang 110016, peoples r china.;liu, xg (reprint author), chinese acad sci, shenyang natl lab mat sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china.;liuxianguohugh@gmail.com

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Synergistic Osteogenic and Antiapoptotic Framework Nucleic Acid Complexes Prevent Diabetic Osteoporosis

Advanced Functional Materials (2024)

Long Bai Maogeng Feng Qiuwen Zhang Zhengwen Cai Qiumei Li

Abstract Diabetes mellitus (DM) is characterized by elevated blood glucose and advanced glycation end product (AGEs) levels. Increased AGEs in bone tissue inhibit osteogenic differentiation by bone marrow mesenchymal stem cells (BMSCs), leading to bone loss and osteoporosis in diabetic patients. Enhancing the osteogenic differentiation capacity of BMSCs in the presence of abundant AGEs can improve bone health and prevent osteoporosis in DM patients. The flavonoid, Quercetin, has anti‐inflammatory, antibacterial, and antitumor properties; however, it is insoluble in water and thus not easily absorbed by the body. Nanodrug delivery systems such as tetrahedral framework nucleic acids (tFNAs) exhibit excellent biocompatibility, efficient cell uptake, and drug piggybacking. In the present study, tFNAs with quercetin is complexed to form a novel nanodrug (tFNAs/Que) that combined the features of both components. tFNAs/Que promote osteogenic differentiation by BMSCs in an in vitro AGEs‐rich environment, maintain bone mass, and prevent diabetic osteoporosis in DM mice in vivo. The mechanism of tFNAs/Que against AGEs may be related to the JNK signaling pathway. In conclusion, it is shown that tFNAs/Que has a dual regulatory role by promoting osteogenic differentiation and inhibiting apoptosis. Such a feature is promising for the prevention and treatment of diabetic osteoporosis.

Biocompatibility

Advanced glycation end-product

10.1002/adfm.202314789

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