To retrospectively analyze the clinical data of 48 patients with allergic bronchopulmonary aspergillosis (ABPA) at Shanghai Pulmonary Hospital.There were 23 males and 25 females with a mean age of (36 ± 15) years.Their clinical manifestations included wheeze,cough,sputum production,sputum plugs,fever,hemoptysis,weight loss,chest pain,weakness and night sweats.They had a high peripheral blood eosinophilia,a higher serum total IgE,a higher level of aspergillosis fumigatus-specific IgE and positive immediate skin-prick test to aspergillus fumigatus.Aspergillus species were detected in sputum samples of 26 patients.Chest computed tomography (CT) was performed in 48 patients.There were patchy infiltrations (n =45),transient infiltrations (n =40),central bronchiectasis (n =35) and mucoid impaction (n =18).Obstructive ventilation dysfunction was confirmed by lung function test.
Key words:
Hypersensitivity; Aspergillosis,allergic bronchopulmonary
Abstract Foot‐and‐mouth disease virus (FMDV) infection modulates the retinoic acid‐inducible gene I (RIG‐I)‐like receptors (RLRs) pathways to inhibit the innate immune responses in the host. However, the mechanism by which FMDV antagonizes the DNA‐induced signaling pathway remains to be clarified. In this study, we determined that FMDV infection inhibited stimulator of interferon genes (STING) at the levels of both mRNA and protein expression, and FMDV 2B and 3C pro proteins promoted STING decline. FMDV 3C pro induced the decrease in STING depending on its protease activity. FMDV 2B reduced STING expression by disrupting its mRNA level. Mechanistically, 2B inhibited the mRNA of STING by recruiting YTH m6A RNA‐binding protein 2 (YTHDF2) to bind to STING mRNA, repressing the generation of FMDV‐induced type‐I interferon and facilitating virus replication. This effect was triggered by residue 105 of 2B. The 2B K105A mutant FMDV was successfully rescued, and further studies showed that the pathogenicity was attenuated by mutation at site K105 of FMDV 2B. YTHDF2 also promoted FMDV replication through interferon‐dependent and interferon‐independent pathways. Moreover, YTHDF2‐deficient mice showed stronger resistance to FMDV infection. Our study reveals a potential mechanism for FMDV 2B negatively modulating innate immunity at transcriptional levels, promoting the understanding of immune evasion and YTHDF2 function in the FMDV infection process.
Background and Objectives: This study explores the practice and effectiveness of medical technology management in specialized hospitals based on the concept of total quality management (TQM). Methods: Focusing on a specialized tertiary respiratory hospital and guided by the framework of TQM theory, this research takes robotic surgery as an example to delineate whole-process management measures and systems for medical technologies, especially restricted technologies, and analyzes the technology’s practical performance. Results: In 2021, the filing of robotic surgery technology for record was officially approved, marking the start of its clinical use; throughout the year, a total of 710 surgeries were performed. Robotic surgery outperformed traditional surgical approaches in terms of unplanned reoperation, intraoperative and postoperative blood transfusion, and 14-day readmission rates. Conclusion: Implementing relevant measures in technology access management, quality supervision, and performance incentives for robotic surgery may not only promote the vigorous development of the technology but also enhance medical quality and ensure patient safety.
The paper makes a comparative analysis of the clinical application value of exhaled nitric oxide (FeNO) in bronchial asthma combined with allergic rhinitis and simple bronchial asthma.It includes the comparison of the difference in FeNO measurement value, the correlation between FeNO and peripheral blood eosinophil percentage (EOS%), serum total specific antibody IgE (IgE) and lung function.In the paper, a total of 53 patients diagnosed and treated in Sijing Hospital of Shanghai Songjiang District were collected.The following groups were as follows: bronchial asthma complicated with allergic rhinitis group (AS+AR), 18 patients, simple bronchial asthma group (AS) 16 people, and control group 19 people.FeNO, peripheral blood EOS%, serum total IgE and lung function were measured respectively.Through SPSS statistical software analysis, it is concluded that there is a significant difference in terms of FeNO among AS+AR group, AS group and control group.The difference between AS+AR group and AS group is statistically significant (P<0.001),compared with those of AS group (three): the AS+AR group is higher than that of AS and control group, and the AS group is higher than that of the control group ( 22).There was a significant difference in EOS% between AS+AR group and AS group (P<0.001).There was a great difference between AS+AR group and control group (P<0.001).There was no significant difference between AS group and control group (P=0.102).The mean value of AS+AR group was higher than that of AS group and control group, and that of AS group was higher than that of control group.The total IgE was significantly different between the AS+AR group and the control group (P<0.01).There was a significant difference between the AS group and the control group (P<0.001).There was no significant difference between the AS+AR group and the AS group (P=0.751), the mean value: AS+AR group was higher than that of the AS group and the control group, and the AS group was higher than the control group.There was a significant difference between FEVl and FVC% in AS group and control group (P<0.01).There was a significant difference between AS+AR group and control group (P<0.05).There was no significant difference between AS group and AS+AR group (P=0.318).Mean: the control group was higher than that of AS+AR group and AS group, and the AS+AR group was higher than that of group AS.Index correlation: there is a significant positive correlation between FeNO and IgE (P<0.01);FeNO has a significant positive correlation with Eos% (P<0.01);FeNO has a significant negative correlation with FEV1/FVC% (P<0.01);there is a significant positive correlation between IgE and Eos% (IgE).Thus, FeNO is an objective index reflecting the chronic airway inflammation, objectively reflecting the degree of allergic airway inflammation, in time to assess the condition of patients with asthma, which is worthy of attention on allergic rhinitis; FeNO and EOS%, IgE, FEVl / FVC% complement each other, mutual influence, clinical the reference of diagnosis and treatment evaluation for allergic respiratory disease.
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