Biannual ultrasonography (US) is a current recommendation for hepatocellular carcinoma (HCC) surveillance in a high-risk group. The sensitivity of US, however, has been low in patients with a high risk of developing HCC. We aimed to compare sensitivity for HCC of biannual US and two-phase low-dose computed tomography (LDCT) in patients with a high risk of HCC.In this prospective single-arm study, participants with an annual risk of HCC greater than 5% (based on a risk index of ≥2.33) and who did not have a history of HCC were enrolled from November 2014 to July 2016. Participants underwent paired biannual US and two-phase LDCT 1-3 times. Two-phase LDCT included arterial and 3-min delayed phases. The sensitivity, specificity, and positive predictive value of HCC detection using US and two-phase LDCT were compared using a composite algorithm as a standard of reference.Of the 139 enrolled participants, 137 underwent both the biannual US and two-phase LDCT at least once and had follow-up images. Among them, 27 cases of HCC (mean size: 14 ± 4 mm) developed in 24 participants over 1.5 years. Two-phase LDCT showed a significantly higher sensitivity (83.3% [20/24] vs. 29.2% [7/24], p < 0.001) and specificity (95.6% [108/113] vs. 87.7% [99/113], p =0.03) than US. A false-positive result was reported in 14 participants at US and 5 participants at two-phase LDCT, resulting in a significantly higher positive predictive value of two-phase LDCT (33.3% [7/21] vs. 80% [20/25], p < 0.001).Patients with a risk index ≥2.33 showed a high annual incidence of HCC development in our study, and two-phase LDCT showed significantly higher sensitivity and specificity for HCC detection than US.
The aim of this study was to evaluate light emitting diodes (LEDs) as the potential attractants against Spodoptera exigua on various wavelengths, light intensity and light duration, and compared to that of commercial control, flourescent lamp. The phototactic response to S. exigua was tested by single and complex wavelengths. The single wavelengths were composed as follows: blue (470 nm), green (520 nm), yellow (590 nm) and red (625 nm). The complex wavelengths was combined with two single wavelengths, such as blue-green, blue-yellow, blue-red, green-yellow, green-red and yellow-red. When the optimal light condition was investigated, the all light treatments attracted the highest number of S. exigua at 40 lux intensity and 60 min duration. Based on the single wavelengths under optimal light condition, the green LED exhibited the highest attraction rate (88.9%), followed by blue (81.1%), yellow (63.3%) and red (56.7%), respectively. In case of complex wavelengths under same conditions, the bluegreen complex (93.3%) had the significantly highest attractive activity, whereas blue-yellow, blue-red, green-yellow, green-red and yellow-red wavelengths were slightly decreased in comparison with single wavelengths. These data clearly show that blue-green complex had the greatest attraction against S. exigua.
The acaricidal and insecticidal potential of the active constituent isolated from Citrullus colocynthis fruits and its structurally related analogues was evaluated by performing leaf disk, contact toxicity, and fumigant toxicity bioassays against Tetranychus urticae, Sitophilus oryzae, and Sitophilus zeamais adults. The active constituent of C. colocynthis fruits was isolated by chromatographic techniques and was identified as 4-methylquinoline on the basis of spectroscopic analyses. To investigate the structure–activity relationships, 4-methylquinoline and its structural analogues were tested against mites and two insect pests. On the basis of the LC50 values, 7,8-benzoquinoline was the most effective against T. urticae. Quinoline, 8-hydroxyquinoline, 2-methylquinoline, 4-methylquinoline, 6-methylquinoline, 8-methylquinoline, and 7,8-benzoquinoline showed high insecticidal activities against S. oryzae and S. zeamais regardless of the application method. These results indicate that introduction of a functional group into the quinoline skeleton and changing the position of the group have an important influence on the acaricidal and insecticidal activities. Furthermore, 4-methylquinoline isolated from C. colocynthis fruits, along with its structural analogues, could be effective natural pesticides for managing spider mites and stored grain weevils.
Objective : The Dry Eye Syndrome is characterized by reduction of the stability of the tearfilm and a set of alterations of the eye surface which could relate to tear quality, normal makeup of tearfilm and alterations in blinking or regular closing of eyelids. We treated 3 patients who was suffering...
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