Elisabeth Soulier

Centre de Résonance Magnétique Biologique et Médicale

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Jean‐Philippe Ranjeva

Aix-Marseille Université

Sylviane Confort‐Gouny

Centre de Résonance Magnétique Biologique et Médicale

Jean Pelletier

Hôpital de la Timone

Maxime Guye

Aix-Marseille Université

Patrick J. Cozzone

Agency for Science, Technology and Research

Bertrand Audoin

Hôpital de la Timone

Patrick Viout

Centre National de la Recherche Scientifique

Wafaa Zaaraoui

Centre de Résonance Magnétique Biologique et Médicale

Irina Malikova

Centre National de la Recherche Scientifique

Audrey Rico

Centre National de la Recherche Scientifique

Cooperative Institutions

Aix-Marseille Université

Centre National de la Recherche Scientifique

Hôpital de la Timone

Assistance Publique Hôpitaux de Marseille

Centre de Résonance Magnétique Biologique et Médicale

Inserm

Institut de Neurosciences des Systèmes

Institut de Neurobiologie de la Méditerranée

Hôpital Sainte-Marguerite

Institut de Neurosciences de la Timone

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Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study

Scientific Reports (2015)

Catherine Faget-Agius Laurent Boyer Jonathan Wirsich Jean‐Philippe Ranjeva Raphaëlle Richieri

Abstract The aim of this study was to investigate the neural substrate underlying quality of life (QoL) and to demonstrate the microstructural abnormalities associated with impaired QoL in a large sample of patients with schizophrenia, using magnetisation transfer imaging. A total of 81 right-handed men with a diagnosis of schizophrenia and 25 age- and sex-similar healthy controls were included and underwent a 3T MRI with magnetization transfer ratio (MTR) to detect microstructural abnormalities. Compared with healthy controls, patients with schizophrenia had grey matter (GM) decreased MTR values in the temporal lobe (BA21, BA37 and BA38), the bilateral insula, the occipital lobe (BA17, BA18 and BA19) and the cerebellum. Patients with impaired QoL had lower GM MTR values relative to patients with preserved QoL in the bilateral temporal pole (BA38), the bilateral insula, the secondary visual cortex (BA18), the vermis and the cerebellum. Significant correlations between MTR values and QoL scores (p < 0.005) were observed in the GM of patients in the right temporal pole (BA38), the bilateral insula, the vermis and the right cerebellum. Our study shows that QoL impairment in patients with schizophrenia is related to the microstructural changes in an extensive network, suggesting that QoL is a bio-psychosocial marker.

Neural substrate

Magnetization transfer

Cerebellar vermis

10.1038/srep17650

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Citations (18)

Occurrence of neuronal dysfunction during the first 5 years of multiple sclerosis is associated with cognitive deterioration

Journal of Neurology (2010)

Wafaa Zaaraoui Françoise Reuter Audrey Rico Anthony Faivre Lydie Crespy

Cognitive reserve

Neuroradiology

Posterior cingulate

Neurochemistry

10.1007/s00415-010-5845-4

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Citations (17)

Structure of WM bundles constituting the working memory system in early multiple sclerosis: A quantitative DTI tractography study

NeuroImage (2007)

Bertrand Audoin Maxime Guye Françoise Reuter My-Van Au Duong Sylviane Confort‐Gouny

10.1016/j.neuroimage.2007.04.038

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Citations (110)

Structural and functional reorganization of working memory system during the first decade in schizophrenia. A cross-sectional study

Schizophrenia Research (2013)

Catherine Faget-Agius Laurent Boyer Christophe Lançon Raphaëlle Richieri E. Fassio

10.1016/j.schres.2013.10.023

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Citations (9)

Relationships between gray matter metabolic abnormalities and white matter inflammation in patients at the very early stage of MS

Journal of Neurology (2007)

My-Van Au Duong Bertrand Audoin Yann Le Fur Sylviane Confort‐Gouny Irina Malikova

Creatine

Choline

Neuroradiology

10.1007/s00415-006-0474-7

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Citations (36)

In vivo quantification of brain injury in adult Niemann–Pick Disease Type C

Molecular Genetics and Metabolism (2011)

Wafaa Zaaraoui Lydie Crespy Audrey Rico Anthony Faivre Elisabeth Soulier

Grey matter

Imaging biomarker

Surrogate endpoint

10.1016/j.ymgme.2011.02.013

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Citations (17)

Improvement of spasticity following intermittent theta burst stimulation in multiple sclerosis is associated with modulation of resting-state functional connectivity of the primary motor cortices

Multiple Sclerosis Journal (2016)

Clémence Boutière Caroline Rey Wafaa Zaaraoui Arnaud Le Troter Audrey Rico

Background: Intermittent theta burst stimulation (iTBS) of the primary motor cortex improves transiently lower limbs spasticity in multiple sclerosis (MS). However, the cerebral mechanisms underlying this effect have never been investigated. Objective: To assess whether modulation of spasticity induced by iTBS is underlined by functional reorganization of the primary motor cortices. Methods: A total of 17 patients with MS suffering from lower limbs spasticity were randomized to receive real iTBS or sham iTBS during the first half of a 5-week indoor rehabilitation programme. Spasticity was assessed using the Modified Ashworth Scale and the Visual Analogue Scale at baseline, after the stimulation session and at the end of the rehabilitation programme. Resting-state functional magnetic resonance imaging (fMRI) was performed at the three time points, and brain functional networks topology was analysed using graph-theoretical approach. Results: At the end of stimulation, improvement of spasticity was greater in real iTBS group than in sham iTBS group ( p = 0.026). iTBS had a significant effect on the balance of the connectivity degree between the stimulated and the homologous primary motor cortex ( p = 0.005). Changes in inter-hemispheric balance were correlated with improvement of spasticity (rho = 0.56, p = 0.015). Conclusion: This longitudinal resting-state fMRI study evidences that functional reorganization of the primary motor cortices may underlie the effect of iTBS on spasticity in MS.

Modified Ashworth scale

10.1177/1352458516661640

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Citations (58)

A MRS-MRI-fMRI exploration of the brain. Impact of long-lasting persistent vegetative state

Brain Injury (2008)

Michel Rousseau Sylviane Confort‐Gouny Andreu Català J. Graperon J. Blaya

The persistent vegetative state (PVS) is a devastating medical condition characterized by preserved wakefulness contrasting with absent voluntary interaction with the environment. However, very little is known about the actual degree of perception in these patients and the extent of progressive brain injury induced by very prolonged unawareness.The authors have conducted a 2-year longitudinal study using a multimodal MRI-MRSI-fMRI protocol in four patients in long-lasting PVS (over 3 years at inclusion) characterized by various brain injuries.Although one subject showed initially preserved local brain metabolism and brain activity related to primary perception suggesting the presence of potential residual brain plasticity even in this critical stage, none of the four patients recovered to consciousness during the 2 years of the protocol. Moreover, significant deterioration of parameters related to brain atrophy, metabolism and functional excitability of primary cortices was observed in all patients during the follow-up.Heterogeneity of brain injury, consequences of long term minimal brain activity and potential factors that prevent recovery to consciousness are discussed.

Persistent vegetative state

Brain damage

10.1080/02699050801895415

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Citations (17)

Depletion of brain functional connectivity enhancement leads to disability progression in multiple sclerosis: A longitudinal resting-state fMRI study

Multiple Sclerosis Journal (2016)

Anthony Faivre Emmanuelle Robinet Maxime Guye Célia Rousseau Adil Maarouf

The compensatory effect of brain functional connectivity enhancement in relapsing-remitting multiple sclerosis (RRMS) remains controversial.To characterize the relationships between brain functional connectivity changes and disability progression in RRMS.Long-range connectivity, short-range connectivity, and density of connections were assessed using graph theoretical analysis of resting-state functional magnetic resonance imaging (fMRI) data acquired in 38 RRMS patients (disease duration: 120 ± 32 months) and 24 controls. All subjects were explored at baseline and all patients and six controls 2 years later.At baseline, levels of long-range and short-range brain functional connectivity were higher in patients compared to controls. During the follow-up, decrease in connections' density was inversely correlated with disability progression. Post-hoc analysis evidenced differential evolution of brain functional connectivity metrics in patients according to their level of disability at baseline: while patients with lowest disability at baseline experienced an increase in all connectivity metrics during the follow-up, patients with higher disability at baseline showed a decrease in the connectivity metrics. In these patients, decrease in the connectivity metrics was associated with disability progression.The study provides two main findings: (1) brain functional connectivity enhancement decreases during the disease course after reaching a maximal level, and (2) decrease in brain functional connectivity enhancement participates in disability progression.

Post-hoc analysis

10.1177/1352458516628657

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Citations (68)

Metabolic counterparts of sodium accumulation in Multiple Sclerosis: A whole brain 1H-MRSI and 23Na-MRI study

HAL (Le Centre pour la Communication Scientifique Directe) (2017)

Maxime Donadieu Adil Maarouf Yann Le Fur Soraya Gherib Elisabeth Soulier

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