Katherine Aguirre

New York Hospital Queens

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Alan Tyroch

Texas Tech University

Evan Liggett

Texas Tech University

Sherif Elhanafi

Texas Tech University

Alexander Philipovskiy

Sarah Cannon

Benjamin Clapp

Texas Tech University

Ioannis T. Konstantinidis

Texas Tech University Health Sciences Center

Shintaro Chiba

Texas Tech University

Isaac Lee

Columbia University

Felipe B. Maegawa

Emory University

Maria Ahmad

Dudley Group NHS Foundation Trust

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Texas Tech University Health Sciences Center

Texas Tech University

University of Arizona

Southern Arizona VA Health Care System

The University of Texas Health Science Center at Houston

The University of Texas at El Paso

University Medical Center

The University of Texas Health Science Center at San Antonio

University Medical Center of El Paso

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Gastrointestinal melanoma: Outcomes of surgery and immunotherapy.

Journal of Clinical Oncology (2022)

Sarah Mazal Maleka Najmi Maria Ahmad Katherine Aguirre Sherif Elhanafi

e16224 Background: Most knowledge on gastrointestinal (GI) melanoma is limited to anal melanoma. Our aim is to examine the impact of surgical treatment and the utility of immunotherapy on GI (other than anal) melanoma. Methods: The National Cancer Database (2004-2016) was reviewed for patients who were treated for GI melanoma. Kaplan-Meier method and log-rank test were used to make survival comparisons. Results: We analyzed data from 731 patients with gastrointestinal melanoma (esophageal:97, gastric:57, small bowel:87, colonic:31, rectal:459). A minority of patients had metastatic disease at the time of diagnosis (esophageal:14.4%, gastric:17.5%, small bowel:4.6%, colonic:19.4%, rectal: 16.3%) and small proportion received immunotherapy (esophageal:16.5%, gastric:15.8%, small bowel:15%, colonic:6.5%, rectal:20.3%). Patients who had resection with negative margins had an improved survival irrespectively of the magnitude of surgery (for example rectal melanoma: OS: no surgery:7.9mo, local excision:23.3mo, partial proctectomy:23.5mo, total proctectomy:18.4mo; p < 0.001 and OS for R0 margins:29.4mo vs R1:13.5mo vs R2:5mo;p < 0.001). The use of immunotherapy was associated with improved survival in metastatic disease for rectal melanoma (OS:10.8mo vs 5.7mo; p = 0.01). Conclusions: Excision with negative margins is associated with improved outcomes in gastrointestinal melanoma. The use of immunotherapy should be considered in the presence of metastatic disease.

Mucosal melanoma

10.1200/jco.2022.40.16_suppl.e16224

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Citations (1)

Concomitant Hiatal Hernia Repair with Sleeve Gastrectomy: A 5-Year Analysis

JSLS Journal of the Society of Laparoscopic & Robotic Surgeons (2020)

Benjamin Clapp Evan Liggett Ashtyn Barrientes Katherine Aguirre Vidur Marwaha

Background: The sleeve gastrectomy (SG) can be associated with postoperative gastroesophageal reflux and when a hiatal hernia (HH) is present, it should be fixed. Earlier studies have shown that 20% of SG have a concomitant hiatal hernia repair (SG+HHR). The aim of this project is to determine the rate of SG+HHR in a large state administrative database.Methods: The Texas Inpatient Public Use Data File (IPUDF) and Outpatient Public Use Data File (OPUDF) for the years 2013-2017 were examined for patients that underwent SG+HHR at the same time. Patient demographics, diagnosis, and charge data were also examined. A t-test was performed between groups and P was considered significant at < 0.05.Results: In the OPUDF, there were 6,193 (33.7%) patients who underwent SG+HHR out of 18,403 patients who underwent SG. Mean charges were $94,741 [standard deviation (SD) = $87,284]. Length of stay (LOS) was 2.1 (SD = 3.5) vs 2.3 days (SD = 3.3) with a shorter stay for SG+HHR vs SG alone (P < 0.001). In the IPUDF, there were 11,536 (21.1%) patients who underwent SG+HHR out of 54,545 patients who underwent SG. Mean charges were $69,006 (SD = $46,365). LOS was 1.59 days (SD = 3.7) for SG+HHR vs 1.63 days (SD = 1.6) for SG (P = .043). The rate of SG+HHR increased over the study period.Conclusions: SG+HHR is common in both the outpatient and inpatient setting. There is a yearly trend of increasing rates of SG+HHR.

Hiatal Hernia

Concomitant

Sleeve gastrectomy

Demographics

10.4293/jsls.2020.00066

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Citations (10)

Mo1574 – Gastric Electrical Neurostimulation Combined with Pyloroplasty is the Final Solution for Refractory Gastroparesis Based on Subjective and Objective Longterm Outcomes

Gastroenterology (2019)

Irene Sarosiek Brian R. Davis Osvaldo Padilla Karina Espino Natalia Vega

Gastroparesis

Pyloroplasty