Yi‐Yin Liu

Kaohsiung Municipal Hsiao-Kang Hospital

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Wen‐Jing Xiao

Central China Normal University

Jia‐Rong Chen

Wuhan College

Shu‐Wen Duan

Central China Normal University

De‐Qing Shi

China University of Petroleum, East China

Liang‐Qiu Lu

Central China Normal University

Cheng‐Yu Long

Kaohsiung Medical University

Zi-Xi Loo

Kaohsiung Medical University

Kun‐Ling Lin

Kaohsiung Medical University

Yun‐Hang Liu

Central China Normal University

Tian‐Ren Li

University of Basel

Cooperative Institutions

Central China Normal University

Kaohsiung Medical University

Kaohsiung Medical University Chung-Ho Memorial Hospital

Chinese Academy of Sciences

Kaohsiung Municipal Hsiao-Kang Hospital

Kaohsiung Municipal Ta-Tung Hospital

Zhengzhou University

Collaborative Innovation Center of Chemical Science and Engineering Tianjin

Zero to Three

Chongqing University

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Photoredox/Cobalt-Catalyzed Phosphinyloxy Radical Addition/Cyclization Cascade: Synthesis of Phosphaisocoumarins

The Journal of Organic Chemistry (2019)

Ming‐Ming Qiao Yi‐Yin Liu Sheng Yao Tian-Cong Ma Zilong Tang

A novel visible-light photoredox-catalyzed phosphinyloxy radical addition/cyclization cascade of arylphosphinic acids or arylphosphonic acid monoesters with alkynes has been developed, which provides an efficient and practical access to various phosphaisocoumarins by using a dual catalytic system containing an acridinium photosensitizer and a cobaloxime proton-reducing catalyst [Co(dmgH)2]PyCl at ambient temperature. This method has advantages of a broad substrate scope, mild condition, as well as no sacrificial oxidant.

Photoredox catalysis

Visible spectrum

10.1021/acs.joc.9b00570

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Citations (14)

Synthesis of CF₃-Containing 3,3′-Cyclopropyl Spirooxindoles by Sequential [3 + 2] Cycloaddition/Ring Contraction of Ylideneoxindoles with 2,2,2-Trifluorodiazoethane

The Journal of Organic Chemistry (2014)

Tian‐Ren Li Shu‐Wen Duan Wei Ding Yi‐Yin Liu Jia‐Rong Chen

A [3 + 2] cycloaddition/ring contraction sequence of ylideneoxindoles with in situ-generated 2,2,2-trifluorodiazoethane without the use of any transition-metal catalyst has been developed. The reaction provides efficient access to biologically important and synthetically useful CF3-containing 3,3'-cyclopropyl spirooxindoles in high yield (74-99%) with high diastereoselectivity (>95:5 d.r.).

Sequence (biology)

10.1021/jo500019a

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Citations (92)

STUDIES ON ORGANOMETALLIC COMPOUNDS OF TITANIUM,ZIRCONIUM AND HAFNIUM——THE SYNTHESES AND PROPERTIES OF BIS (CYCLOPENTADIENYL) AND BIS (METHYLCYCLOPENTADIENYL) DI(ARYL)-METAL DERIVATIVES

Science China Chemistry (1982)

Shoushan Chen Yi‐Yin Liu Wang Ji‐Tao

Cyclopentadienyl complex

Hafnium

10.1360/yb1982-25-4-341

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Visible‐Light‐Driven Aza‐ortho‐quinone Methide Generation for the Synthesis of Indoles in a Multicomponent Reaction

Angewandte Chemie (2017)

Yi‐Yin Liu Xiaoye Yu Jia‐Rong Chen Ming‐Ming Qiao Xiaotian Qi

Abstract A visible‐light‐driven radical‐mediated strategy for the in situ generation of aza‐ ortho ‐quinone methides from 2‐vinyl‐substituted anilines and alkyl radical precursors is described. This process enables an efficient multicomponent reaction of 2‐vinylanilines, halides, and sulfur ylides, and has a wide substrate scope and good functional group tolerance. Treatment of the cycloaddition products with a base leads to densely functionalized indoles in a single‐flask operation.

Quinone methide

Functional group

Visible spectrum

10.1002/ange.201704690

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Citations (35)

Metallaphotoredox‐Catalyzed Three‐Component Couplings for Practical Synthesis of Ureas and Carbamates^†

Chinese Journal of Chemistry (2023)

Ernest Koranteng Zhen‐Cao Shu Yi‐Yin Liu Qian Yang Bin Shi

Comprehensive Summary Ureas are widely used in drugs, materials and catalysts because of their diamide structure, which can form strong hydrogen bonds. Therefore, it is of great scientific significance to develop efficient and green methods for the synthesis of urea compounds, especially unsymmetrical ureas. Here, we have disclosed novel and highly efficient three‐component coupling reactions of organic halides, sodium cyanate and amines enabled by nickel/photoredox dual catalysis for the preparation of unsymmetrical ureas. The reaction features simple and safe operations, broad substrate scopes, and product diversities. It allows the facile synthesis of N ‐aryl/vinyl ureas from readily available, user‐friendly feedstocks under mild conditions (27 examples, 36%—98% yields). In addition, this method is further derived to alcohols as nucleophiles to synthesize a series of carbamates (15 examples, 40%—95% yields). The mechanism experiment shows that the isocyanate produced by the coupling of halide and sodium cyanate may be the key intermediate in this reaction.

Cyanate

Isocyanate

Coupling reaction

10.1002/cjoc.202300500

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Citations (1)

Regioselectivity of reductive-coupling reaction of alkynes in the presence of titanocene and zirconocene dichloride

Acta Chimica Sinica (1987)

Yi‐Yin Liu

A series of (Z,Z)-tetraaryl-1,3-butadiene has been synthesized stereospecifically and regioselectively by acidolysis of five-membered Ti, Zr metallocycles formed from asymmetrically substituted alkynes. The structures of these products have been proved by physical and chemical methods.

Coupling reaction

10.1002/cjoc.19870050212

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Citations (0)

Practical C–P bond formation via heterogeneous photoredox and nickel synergetic catalysis

CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION) (2019)

Ernest Koranteng Yi‐Yin Liu Si-Yue Liu Qiangxian Wu Liang‐Qiu Lu

Photoredox catalysis

Aryl halide

10.1016/s1872-2067(19)63379-6

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Citations (14)

CCDC 1476293: Experimental Crystal Structure Determination

The Cambridge Structural Database (2016)

Yi‐Yin Liu Shu‐Wen Duan Rui Zhang Yun‐Hang Liu Jia‐Rong Chen

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1lk6cq

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Visible‐Light‐Driven Aza‐ortho‐quinone Methide Generation for the Synthesis of Indoles in a Multicomponent Reaction

Angewandte Chemie International Edition (2017)

Yi‐Yin Liu Xiaoye Yu Jia‐Rong Chen Ming‐Ming Qiao Xiaotian Qi

A visible-light-driven radical-mediated strategy for the in situ generation of aza-ortho-quinone methides from 2-vinyl-substituted anilines and alkyl radical precursors is described. This process enables an efficient multicomponent reaction of 2-vinylanilines, halides, and sulfur ylides, and has a wide substrate scope and good functional group tolerance. Treatment of the cycloaddition products with a base leads to densely functionalized indoles in a single-flask operation.

Quinone methide

Functional group

Visible spectrum

10.1002/anie.201704690

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Citations (140)

ChemInform Abstract: Synthesis of CF₃‐Containing 3,3′‐Cyclopropyl Spirooxindoles by Sequential [3 + 2] Cycloaddition/Ring Contraction of Ylideneoxindoles with 2,2,2‐Trifluorodiazoethane.

ChemInform (2014)

Tian‐Ren Li Shu‐Wen Duan Wei Ding Yi‐Yin Liu Jia‐Rong Chen

Abstract This is the first example of [3 + 2] cycloaddition/ ring contraction sequence under transition‐metal‐free conditions yielding the title spiro compounds.

Sequence (biology)

10.1002/chin.201434127

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Citations (0)