Saba Nikanfar

UCLouvain

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Mohammad Nouri

Tabriz University of Medical Sciences

Amir Fattahi

Tabriz University of Medical Sciences

Reza Zarezadeh

Tabriz University of Medical Sciences

Hajar Oghbaei

Tabriz University of Medical Sciences

Yeganeh Rastgar Rezaei

Tabriz University of Medical Sciences

Ralf Dittrich

Comprehensive Cancer Center Erlangen

Hamid Reza Nejabati

Tabriz University of Medical Sciences

Fatemeh Kheradmand

Urmia University

Sanya Haiaty

Tabriz University of Medical Sciences

Yadollah Ahmadi

Tabriz University of Medical Sciences

Cooperative Institutions

Tabriz University of Medical Sciences

University of Tabriz

Urmia University

Tehran University of Medical Sciences

Urmia University of Medical Sciences

Imam Reza Hospital

Biotechnology Research Center

Sakarya University

Shahid Beheshti University of Medical Sciences

Alzahra Medical and Education Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Oncostatin M: friend or foe in PCOS pathogenesis

Journal of Endocrinology (2024)

Saba Nikanfar Farnaz Oghbaei Hamid Reza Nejabati Reza Zarezadeh Zeinab Latifi

Polycystic ovary syndrome (PCOS) is a primary endocrinological disorder in women of reproductive age that is characterized by androgen excess and ovulatory irregularities. This syndrome is associated with adipose tissue dysfunction, an elevated risk of insulin resistance, hyperinsulinemia, obesity, and type 2 diabetes. Adipocyte dysfunction affects the secretion of adipokines and pro-inflammatory cytokines. Nevertheless, adipose tissue is not an exclusive source of adipokines as it can also be produced locally by reproductive tissues. Although adipokines have been recognized in the development of PCOS, the role of oncostatin M (OSM), a multifaceted adipokine, remains unclear. Current evidence suggests that this cytokine is associated with key aspects of the syndrome, including obesity, insulin resistance, hyperandrogenism, and inflammation. However, the data are often contradictory, likely due to variations in study designs, methodologies, and species differences. By investigating the link between OSM and PCOS-associated issues, this review identified the potential role of this adipokine in PCOS pathogenesis. This underscores the need for further research to clarify its predominant effects and assess its relevance as a therapeutic target.

Hyperandrogenism

Hyperinsulinemia

Chemerin

Resistin

Oncostatin M

10.1530/joe-24-0140

Cite

Citations (2)

Vandetanib alters the tumoricidal capacity of human breast cancer stem cells via inhibiting vasculogenic capacity

Bioimpacts (2022)

Sanya Haiaty Mohammad‐Reza Rashidi Maryam Akbarzadeh Ahad Bazmany Mostafa Mostafazadeh

The inhibition of vascularization into tumor stroma as well as dynamic cell growth is the center of attention. Here, we aimed to examine the role of vandetanib on angiogenesis capacity of breast cancer stem cell (CSCs).MDA-MB-231 cells were exposed to different doses of vandetanib and survival rate was monitored. Stimulatory effects of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and epidermal growth factor (EGF) were evaluated in vandetanib-treated MDA-MB-231 cells. In vitro tubulogenesis capacity was studied on the Matrigel surface. The synergistic effects of vandetanib on cell survival were also assessed after PI3K and/or Wnt3a inhibition. Vascular endothelial (VE)-cadherin, matrix metalloproteinase-2 (MMP-2), -9, Wnt3a, and p-Akt/Akt ratio were measured using western blotting.Vandetanib reduced survival rate in a dose-dependent manner (P<0.05). Proliferative effects associated with VEGF, FGF, and EGF were blunted in these cells pre-exposed to vandetanib (P<0.05). The microcirculation pattern's triple-negative breast cancer (TNBC) was suppressed by 1, 5 µM of vandetanib (P<0.05). Hence 1, 5 µM of vandetanib potentially decreased the population of CD24- cells. 1 and 5 µM of vandetanib inhibited cell proliferation by blocking PI3K and Wnt3a pathways and decreased the p-Akt/Akt ratio, Wnta3 protein levels (P<0.05). 1 and 5 µM vandetanib combined with PI3K inhibitor diminished metastatic markers including, MMP-2, and MMP-9. The concurrent treatment (PI3K, inhibitor+ 1, 5 µM vandetanib) also considerably reduced epithelial-mesenchymal transition (EMT) markers such as VE-cadherin (P<0.05).Vandetanib suppressed vasculogenic mimicry (VM) networking through blunting stemness properties, coincided with suppression of VE-cadherin in CSCs.

Vandetanib

Matrigel

10.34172/bi.2022.24208

Cite

Citations (1)

Is there a link between Persian medicine eating habits and the nutritional status of older adults? A cross-sectional study

Advances in Integrative Medicine (2023)

Sarvin Sanaie Zahra Yousefi Alireza Bagherzadeh Karimi Saba Nikanfar Fatemeh Jahanjoo

Cross-sectional study

Positive correlation

10.1016/j.aimed.2023.05.003

Cite

Citations (1)

CORRELATION BETWEEN ZINC AND FASTING BLOOD SUGAR IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND THEIR FIRST-DEGREE RELATIVES

URMIA MEDICAL JOURNAL (2015)

Somayeh Atari-Hajipirloo Neda Valizadeh Mohammad Hassan Khadem Ansari Yousef Rasmi Fatemeh Kheradmand

The altered levels of some essential trace elements and antioxidant minerals have been observed in diabetic patients. Zinc, as an antioxidant and essential trace element, plays a significant role in the function of many enzymes. Altered zinc content seems to be one of the contributing factors in the pathogenesis of this disease. The purpose of this study was to investigate serum level of zinc (Zn) and the correlation between zinc and fasting blood sugar (FBS) in patients with type 2 diabetes mellitus (T2DM) and their first-degree relatives (FDR). Methods & Materials: 46 subjects with T2DM, 46 FDR and 50 healthy subjects were involved in this study. Serum concentrations of Zn were measured by colorimetric kit (Biorex, UK). Fasting blood sugar was assayed using the standard kit (made by Pars Azmoon Inc., Tehran, Iran). Results: We found decreased levels of Zn (P<0.001) in FDR when compared to healthy controls. FBS levels were negatively correlated with Zn (r=0.431,P=0.003) in patients with T2DM. However, there was no correlation between FBS level and Zn (r=0.024,P=0.8) in FDR. Conclusion: Finally, patients with T2DM and their FDR has altered metabolism of Zn which may contribute to increased risk of developing T2DM later on in FDR’s life.

Blood sugar

Fasting blood sugar

First-degree relatives

Source

Cite

Citations (0)

Saffron as a promising therapy for diabetes and Alzheimer's disease: mechanistic insights

Metabolic Brain Disease (2022)

Sarvin Sanaie Saba Nikanfar Zahra Yousefi Akbar Azizi-Zeinalhajlou Saeed Sadigh‐Eteghad

Amyloid beta

10.1007/s11011-022-01059-5

Cite

Citations (10)

Role of adipokines in the ovarian function: Oogenesis and steroidogenesis

The Journal of Steroid Biochemistry and Molecular Biology (2021)

Saba Nikanfar Hajar Oghbaei Yeganeh Rastgar Rezaei Reza Zarezadeh Davoud Jafari-Gharabaghlou

10.1016/j.jsbmb.2021.105852

Cite

Citations (26)

Effects of bacteria on male fertility: Spermatogenesis and sperm function

Hajar Oghbaei yegane rastgar rezaei Saba Nikanfar Reza Zarezadeh Mohammad Reza Sadeghi

Male fertility

Source

Cite

Citations (0)

Epididymosomes: the black box of Darwin’s pangenesis?

Molecular Human Reproduction (2020)

Hamid Reza Nejabati Vahideh Shahnazi Yousef Faridvand Nazila Fathi-Maroufi Zahra Bahrami‐Asl

Abstract Darwin, in the pangenesis theory, imagined particles, named as ‘gemmules’, which are released from all (‘pan’) cells of the body. By cell–cell communication and also circulation through the body, they finally reach the germ cells to participate in the generation (‘genesis’) of the new individual. It has been shown that circulatory exosomes are affected by environmental stressors and they can reach the parental germ cells. Therefore, in the mirror of his theory, circulatory exosomes could interact with epididymosomes: epididymis-derived exosomes which have a wide spectrum of variation in content and size, are very sensitive to environmental stressors, and may be involved in translating external information to the germ cells. The protein and RNA cargo would be transferred by epididymosomes to sperm during sperm maturation, which would be then delivered to the embryo at fertilization and inherited by offspring. Therefore, in this study, we will briefly discuss Darwin’s pangenesis theory and its possible relation with epididymosomes. We believed that epididymosomes could be considered as an attractive candidate for the storage of RNA contents, changing the epigenome of the next generations, and allowing the reappearance acquired characteristics of ancestors. Therefore, epididymosomes, as a black box of Darwin’s pangenesis, may unravel parental life history and also disclose the historical events that affect the life of offspring.

Epigenome

Egg cell

10.1093/molehr/gaaa079

Cite

Citations (9)

Effects of bacteria on male fertility: Spermatogenesis and sperm function

Life Sciences (2020)

Hajar Oghbaei Yeganeh Rastgar Rezaei Saba Nikanfar Reza Zarezadeh Mohammadreza Sadegi

10.1016/j.lfs.2020.117891

Cite

Citations (37)

microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials

Systems Biology in Reproductive Medicine (2021)

Yeganeh Rastgar Rezaei Reza Zarezadeh Saba Nikanfar Hajar Oghbaei Nahideh Nazdikbin

miRNAs are involved in different biological processes, including proliferation, differentiation, and apoptosis. Interestingly, 38% of the X chromosome-linked miRNAs are testis-specific and have crucial roles in regulating the renewal and cell cycle of spermatogonial stem cells. Previous studies demonstrated that abnormal expression of spermatogenesis-related miRNAs could lead to nonobstructive azoospermia (NOA). Moreover, differential miRNAs expression in seminal plasma of NOA patients has been reported compared to normozoospermic men. However, the role of miRNAs in NOA pathogenesis and the underlying mechanisms have not been comprehensively studied. Therefore, the aim of this review is to mechanistically describe the role of miRNAs in the pathogenesis of NOA and discuss the possibility of using the miRNAs as therapeutic targets.Abbreviations: AMO: anti-miRNA antisense oligonucleotide; AZF: azoospermia factor region; CDK: cyclin-dependent kinase; DAZ: deleted in azoospermia; ESCs: embryonic stem cells; FSH: follicle-stimulating hormone; ICSI: intracytoplasmic sperm injection; JAK/STAT: Janus kinase/signal transducers and activators of transcription; miRNA: micro-RNA; MLH1: Human mutL homolog l; NF-κB: Nuclear factor-kappa B; NOA: nonobstructive azoospermia; OA: obstructive azoospermia; PGCs: primordial germ cells; PI3K/AKT: Phosphatidylinositol 3-kinase/protein kinase B; Rb: retinoblastoma tumor suppressor; ROS: Reactive Oxygen Species; SCOS: Sertoli cell-only syndrome; SIRT: sirtuin; SNPs: single nucleotide polymorphisms; SSCs: spermatogonial stem cells; TESE: testicular sperm extraction; TGF-β: transforming growth factor-beta.

10.1080/19396368.2021.1951890

Cite

Citations (11)