Rats (24 male, 24 female) were tested under methamphetamine or saline in a six-choice-point multiple-T maze. On Trial 1 the rats were exposed to a homogeneous black or white maze. Between daily Trials 1 and 2 the maze was: (a) left unchanged, (b) the culs were changed from Black (B) to White (W) or W to B, or (c) the path was changed from B to W, or W to B. Methamphetamine-treated rats made fewer approach responses to change when the change occurred in the culs and spent less time running from one end of the maze to the other. Methamphetamine reduces the invitational properties normally associated with change or novelty.
Summary Even though randomization tests are the most powerful of nonparametric tests and are the only valid tests to employ when there has been random assignment, but not random selection, of subjects in experiments (a common practice in psychology), such tests are rarely used by psychologists. The limited adoption of randomization tests is primarily a consequence of the great amount of computation they require. The present study shows, however, that the computation for randomization test counterparts of the t test and one-way analysis of variance can be relatively inexpensive when performed by a high-speed computer.
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