Peihong Xiao

University of Electronic Science and Technology of China

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Ben Zhong Tang

University of Hong Kong

Dong Wang

Shenzhen University

Zhenlei Song

Sichuan University

Ying Li

Guangzhou Medical University

Lu Gao

Sichuan University

Lei Wang

Qinghai University

Miaomiao Kang

Fudan University

Zhijun Zhang

Shenzhen University

Haifei Wen

Shenzhen University

Nan Song

Center for Excellence in Brain Science and Intelligence Technology

Cooperative Institutions

Sichuan University

Shenzhen University

University of Hong Kong

Chinese Academy of Sciences

Hong Kong University of Science and Technology

Chengdu University

University of Electronic Science and Technology of China

Chinese University of Hong Kong, Shenzhen

State Key Laboratory of Biotherapy

Wuhan University

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Precise Molecular Engineering of Type I Photosensitizers with Near-Infrared Aggregation-Induced Emission for Image-Guided Photodynamic Killing of Multidrug-Resistant Bacteria

Peihong Xiao Zipeng Shen Deliang Wang Yinzhen Pan Ying Li

Multidrug resistance (MDR) bacteria pose a serious threat to human health. The development of alternative treatment modalities and therapeutic agents for treating MDR bacteria-caused infections remains a global challenge. Herein, we rationally designed and successfully developed a series of near-infrared (NIR) anion-π+ photosensitizers featuring aggregation-induced emission (AIE-PSs) for broad-spectrum MDR bacteria eradication. Due to the strong intramolecular charge transfer (ICT) and enhanced highly efficient intersystem crossing (ISC), these electron-rich anion-π+ AIE-PSs showed boosted type I reactive oxygen species (ROS) generation capability involving hydroxyl radicals and superoxide anion radicals, and up to 99% photodynamic killing efficacy was achieved for both Methicillin-resistant Staphylococcus aureus (MRSA) and multi-drug resistant Escherichia coli (MDR E.coli) under a low dose white light irradiation (16 mW cm-2). In vivo experiments confirmed that one of these AIE-PSs exhibited excellent therapeutic performance in curing MRSA or MDR E.coli-infected wounds with negligible side-effects. The study would thus provide useful guidance for the rational design of high-performance type I AIE-PSs to overcome antibiotic resistance.

Rational design

Intersystem crossing

10.33774/chemrxiv-2021-ltlpw

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Efficient Killing of Multidrug‐Resistant Internalized Bacteria by AIEgens In Vivo

Advanced Science (2021)

Ying Li Fei Liu Jiangjiang Zhang Xiaoye Liu Peihong Xiao

Bacteria infected cells acting as "Trojan horses" not only protect bacteria from antibiotic therapies and immune clearance, but also increase the dissemination of pathogens from the initial sites of infection. Antibiotics are hard and insufficient to treat such hidden internalized bacteria, especially multidrug-resistant (MDR) bacteria. Herein, aggregation-induced emission luminogens (AIEgens) such as N,N-diphenyl-4-(7-(pyridin-4-yl) benzo [c] [1,2,5] thiadiazol-4-yl) aniline functionalized with 1-bromoethane (TBP-1) and (3-bromopropyl) trimethylammonium bromide (TBP-2) (TBPs) show potent broad-spectrum bactericidal activity against both extracellular and internalized Gram-positive pathogens. TBPs trigger reactive oxygen species (ROS)-mediated membrane damage to kill bacteria, regardless of light irradiation. TBPs effectively kill bacteria without the development of resistance. Additionally, such AIEgens activate mitochondria dependent autophagy to eliminate internalized bacteria in host cells. Compared to the routinely used vancomycin in clinic, TBPs demonstrate comparable efficacy against methicillin-resistant Staphylococcus aureus (MRSA) in vivo. The studies suggest that AIEgens are promising new agents for the treatment of MDR bacteria associated infections.

10.1002/advs.202001750

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Citations (72)

Targeting Multidrug‐Resistant Bacteria: Efficient Killing of Multidrug‐Resistant Internalized Bacteria by AIEgens In Vivo (Adv. Sci. 9/2021)

Advanced Science (2021)

Ying Li Fei Liu Jiangjiang Zhang Xiaoye Liu Peihong Xiao

In article number 2001750, Kui Zhu, Ben Zhong Tang and co-workers demonstrate that aggregationinduced emission luminogens such as TBPs trigger ROS-mediated membrane damage to effectively kill internalized bacteria without resistance development. Intriguingly, TBPs promote mitochondria dependent autophagy to eliminate such bacteria in host cells. Similar to vancomycin, TBPs demonstrate high efficacy against notorious bacterial infections in vivo.

10.1002/advs.202170051

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In Situ Electrospinning of Aggregation‐Induced Emission Nanofibrous Dressing for Wound Healing

Small Methods (2022)

Ruihua Dong Ying Li Mian Chen Peihong Xiao Yifan Wu

Rapid wound dressing and effective antibacterial therapy that meet the extreme requirements of emergency situations are urgently needed for treating skin wounds. Here, an in situ deposited and personalized nanofibrous dressing is reported which can be directly electrospun on skin wounds by a handheld electrospinning device and perfectly fits different wounds of various sizes. Moreover, an aggregation-induced emission luminogen with photodynamic therapy effect is loaded in the nanofibrous dressings which endows the dressing's long-term antibacterial activity during the wound healing process. The in situ electrospun nanofibers show excellent antimicrobial activity against Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus. In vivo studies demonstrate that these antibacterial nanofibrous dressings can effectively reduce inflammation and significantly accelerate wound healing. Such an in situ produced antibacterial dressing is promising as a total solution for treating emergencies, including patient-specific clinical wounds and military injuries.

Electrospinning

Wound dressing

10.1002/smtd.202101247

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Citations (95)

ChemInform Abstract: Unique Steric Effect of Geminal Bis(silane) to Control the High exo‐Selectivity in Intermolecular Diels—Alder Reaction.

ChemInform (2016)

Zengjin Liu Xinglong Lin Na Yang Zhishan Su Changwei Hu

Abstract Due to the unique steric effect of di(silyl)methyl (DSM) groups, an exo‐selective intermolecular Diels—Alder reaction of geminal bis(silyl) dienes with α,β‐unsaturated carbonyl compounds is achieved.

Geminal

Diels–Alder reaction

10.1002/chin.201630079

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Innentitelbild: Me₃Si−SiMe₂[oCON(iPr)₂−C₆H₄]: An Unsymmetrical Disilane Reagent for Regio‐ and Stereoselective Bis‐Silylation of Alkynes (Angew. Chem. 17/2018)

Angewandte Chemie (2018)

Peihong Xiao Yanjun Cao Yingying Gui Lu Gao Zhenlei Song

Auf Schmetterlingsflügeln getragenDas unsymmetrische luftstabile Disilan Me3Si-SiMe2[oCON(iPr)2C6H4] bis(silyliert) terminale Alkine hoch regioselektiv und gut verträglich mit funktionellen Gruppen zu Z-Vinyldisilanen. Z. L. Song et al. beschreiben in ihrer Zuschrift auf S. 4859 eine Umwandlung, die mit herkömmlichen Halogenid- oder Methoxy-substituierten unsymmetrischen Disilanen schwer zu erreichen ist – die Metamorphose Kokon-ähnlicher Alkine zu Schmetterlings-ähnlichen Z-Vinylsilanen.

Disilane

10.1002/ange.201802507

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Me₃Si−SiMe₂[oCON(iPr)₂−C₆H₄]: An Unsymmetrical Disilane Reagent for Regio‐ and Stereoselective Bis‐Silylation of Alkynes

Angewandte Chemie (2018)

Peihong Xiao Yanjun Cao Yingying Gui Lu Gao Zhenlei Song

Abstract The air‐stable unsymmetrical disilane Me 3 Si−SiMe 2 [ o CON( i Pr) 2 C 6 H 4 ] has been developed for bis‐silylation of alkynes. This reagent tolerates a range of functional groups, providing Z ‐vinyl disilanes in high yields. It is proposed that the phenyl‐ring‐tethered amide group directs oxidative addition of Pd 0 into the Si−Si bond, which might facilitate formation of a six‐membered Pd cycle, generating products with good to excellent regioselectivity.

Disilane

Amide

Oxidative addition

10.1002/ange.201800513

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Citations (8)

Recent Progress in the Transition‐Metal‐Catalyzed Activation of Si−Si Bonds To Form C−Si Bonds

Chemistry - A European Journal (2018)

Peihong Xiao Lu Gao Zhenlei Song

Abstract Disilanes possessing a Si−Si bond are unique element–element species. Transition‐metal‐catalyzed activation of the Si−Si bond allows many useful transformations that generate diverse organosilanes. This Minireview highlights impressive developments in this field over the past decade, with an emphasis on the formation of vinyl‐, aryl‐, and acylsilanes by C(sp 2 )−Si bond formation as well as the formation of allyl‐ and alkylsilanes by C(sp 3 )−Si bond formation.

10.1002/chem.201803803

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Citations (43)

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews (2022)

Zhijun Zhang Miaomiao Kang Hui Tan Nan Song Meng Li

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting the excited energy dissipation.

10.1039/d1cs01138c

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Citations (266)

An endoplasmic reticulum-targeted NIR fluorescent nanoprobe for early diagnosis of glaucoma in vivo

Sensors and Actuators B Chemical (2024)

Lan Yu Haixia Zhang Ruichen Xie Kecheng Li Feiran Xie

Glaucoma is a leading cause of irreversible blindness worldwide and characterized by progressive loss of retinal ganglion cells (RGCs). As glaucoma progresses asymptomatically and the lack of specific biomarkers or noninvasive imaging tools during the early stage, it is often discovered at a relatively late stage without cure. Development of an effective tool for early diagnosis remains a necessity. As well known, endoplasmic reticulum (ER) stress and subsequent accumulation of reactive oxygen species (ROS) play a vital role in the development of glaucoma, with peroxynitrite (ONOO−) as one of the most abundant cytotoxic ROS. In this work, we constructed a novel near-infrared (NIR) fluorescent nanoprobe named ER-ONOO-NPs. It specifically and sensitively targets ER-associated ONOO− with low biotoxicity in cultured RGCs. Systematically applied to the NMDA-induced mouse model of glaucoma, ER-ONOO-NPs performs well for real-time dynamic monitoring of ONOO− fluctuations at the Ganglion cell layer of mice prior to RGCs apoptosis. Thus, our results suggest that the ER-targeted NIR fluorescent nanoprobe could be a noninvasive imaging tool for early diagnosis of glaucoma in high-risk population.

Nanoprobe

10.1016/j.snb.2024.135441

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