Hossein Sanjari Moghaddam

Mayo Clinic

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Mohammad Hadi Aarabi

University of Padua

Shahin Akhondzadeh

Roozbeh Hospital

Mohammadamin Parsaei

Tehran University of Medical Sciences

Giulia Cattarinussi

University of Padua

Fabio Sambataro

University of Padua

Mahsa Dolatshahi

Washington University in St. Louis

Vajiheh Aghamollaii

Tehran University of Medical Sciences

Alireza Hasanzadeh

Tehran University of Medical Sciences

Abbas Tafakhori

Tehran University of Medical Sciences

Farzaneh Ghazi Sherbaf

Johns Hopkins University

Cooperative Institutions

Tehran University of Medical Sciences

173

Roozbeh Hospital

University of Tehran

Imam Khomeini Hospital

Iran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Universal Scientific Education and Research Network

Children's Medical Center

Shariati Hospital

Mayo Clinic

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Efficacy and safety of palmitoylethanolamide as an adjunctive treatment for acute mania: A randomized, double‐blind, placebo‐controlled trial

Psychiatry and Clinical Neurosciences (2022)

Talieh Abedini Reyhaneh Hosseyni Farnaz Ghannadi Hossein Sanjari Moghaddam Mohammad Reza Khodaie Ardakani

Palmitoylethanolamide is an endogenous fatty acid amide with neuroprotective and anti-inflammatory actions. We performed a randomized, double-blind, placebo-controlled clinical trial to investigate the efficacy and safety of palmitoylethanolamide combination therapy in acute mania.Patients in the acute phase of mania were assigned into two parallel groups given either lithium (blood level of 0.8-1.1 mEq/L) and risperidone 3 mg plus palmitoylethanolamide 600 mg or placebo twice per day for 6 weeks. All participants were assessed with the Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HDRS), and Extrapyramidal Symptom Rating Scale (ESRS) at baseline and at weeks 1, 2, 4, and 6.A total of 63 patients (32 in palmitoylethanolamide and 31 in placebo groups) completed the trial. We found a significant effect for time×treatment interaction on the YMRS score (F = 5.22, d.f. = 2.34, P= 0.004) from baseline to study end point. Results from independent t test showed a significantly greater decrease in YMRS scores in the palmitoylethanolamide group, compared with the placebo group, from baseline to weeks 4 and 6 (P= 0.018 and P= 0.002, respectively). There was no significant difference between palmitoylethanolamide and placebo groups based on ESRS scores or ESRS changes in scores (P>0.05).Our findings provide preliminary evidence that palmitoylethanolamide is an effective adjunctive medication that improves manic symptoms and overall clinical status in acute episodes of mania. However, larger sample sizes and more extended follow-up therapy are needed in future studies to confirm our findings.

Palmitoylethanolamide

10.1111/pcn.13441

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Citations (17)

Interdisciplinary Collaboration between Bench and Bedside in the COVID-19 Pandemic

Avicenna Journal of Medical Biotechnology (2023)

Hossein Sanjari Moghaddam Shahin Akhondzadeh

The Article Abstract is not available.

Pandemic

Bench to bedside

2019-20 coronavirus outbreak

Coronavirus Infections

10.18502/ajmb.v15i2.12015

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Citations (1)

Efficacy and safety of celecoxib for treatment of mild to moderate postpartum depression: a randomized, double-blind, placebo-controlled trial

Archives of Gynecology and Obstetrics (2023)

Sophia Esalatmanesh Ladan Kashani Maryam Khooshideh Hossein Sanjari Moghaddam Sahar Ansari

Celecoxib

Depression

Placebo-controlled study

10.1007/s00404-023-07042-4

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Citations (4)

Author response for "Brain structural and functional abnormalities in patients with tension‐type headache: A systematic review of magnetic resonance imaging studies"

Mohammadamin Parsaei Morvarid Taebi Alireza Arvin Hossein Sanjari Moghaddam

10.1002/jnr.25294/v3/response1

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Citations (0)

Sex differences in brain structures throughout the lifetime

Aging Brain (2023)

Mohammadamin Parsaei Hossein Sanjari Moghaddam Mohammad Hadi Aarabi

The neuroanatomical characteristics of the brain exhibit variations between females and males, encompassing both healthy and pathological conditions [1].Bethlehem et al. (2022) recently developed a human brain chart based on Magnetic Resonance Imaging (MRI) data from over 100,000 participants ranging in age from 115 days post-conception to 100 years [2].This study discovered that males and females have significantly different brain tissue volumes throughout their lives and that these differences can also be seen in the brain growth patterns of people with psychiatric and neurologic conditions.Based on this growth chart trajectory, males have larger brain tissue volumes and more significant variance across MRI phenotypes, compared to females.It is critical to understand the effects of biological sex on brain development as it can significantly affect the physical and mental health of different psychiatric and neurologic patients.Numerous studies have been conducted to compare brain volumes between healthy males and females.These studies have consistently found that males tend to have larger Total Cerebral Volume (TCV), total Grey Matter Volume (GMV), subcortical Grey Matter Volume (sGMV), total White Matter Volume (WMV), and Cerebrospinal Fluid Volume (CSFV).On the other hand, females generally demonstrate a higher mean Cortical Thickness (CTh) [3].Abe et al. ( 2010) examined a population of individuals ranging in age from 21 to 71, revealing that males possess larger total GMV and WMV [4].Additionally, males exhibited higher rates of decline in GMV and WMV with aging compared to females.This suggests that males and females have distinct brain structures, and the patterns of age-related brain changes are also different.The precise etiology behind the lifelong disparities in brain structure between males and females remains incompletely understood.Emerging evidence suggests that these variations may have developmental origins.Certain investigations have identified different phenotypes in male and female brain cells, indicating a critical role of sex chromosomes in the emergence of sex-based brain differences.For instance, in vitro research has revealed that embryonal brain cells with XX and XY chromosomal configurations exhibit divergent behaviors [5].XY cell cultures demonstrate a propensity to yield a higher number of dopamine neurons compared to their XX counterparts [5].This emphasizes the genetic origin of the sex differences in brain structure.Consistent with this perspective, male infants exhibit larger total GMV and WMV compared to their female counterparts [6].Moreover, these discrepancies persist into puberty, with males exhibiting greater total GMV, WMV, and TCV [7].These findings underscore the significance of sex chromosomes in the development and perpetuation of brain differences between males and females.While numerous studies have provided substantial evidence supporting the genetic origin of brain differences between males and females, a considerable body of research has demonstrated significant effects of sex hormones on brain development.Previous research revealed that testosterone acts as a human fetal brain programming system, leading to fetal dimorphism in brain structure and function

10.1016/j.nbas.2023.100098

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Prognostic role of quantitative pupillometry in traumatic brain injury: a scoping review

Neurological Sciences (2024)

Iman Kiani Mohammadamin Parsaei Hanie Karimi Alireza Beikmarzehei Shahnaz Fooladi Sarabi

Pupillometry

Neuroradiology

10.1007/s10072-024-07869-y

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Association of olfaction dysfunction with brain microstructure in prodromal Parkinson disease

Neurological Sciences (2018)

Hossein Sanjari Moghaddam Mahsa Dolatshahi Elaheh Salardini Mohammad Hadi Aarabi

Cingulum (brain)

Splenium

Inferior longitudinal fasciculus

Prodromal Stage

10.1007/s10072-018-3629-2

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Citations (22)

Author response for "Intact microstructure of the right corticostriatal pathway predicts creative ability in healthy adults"

Farzaneh Rahmani Hossein Sanjari Moghaddam Mohammad Hadi Aarabi

10.1002/brb3.1895/v2/response1

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Evaluating efficacy and safety of Saffron add-on treatment in improvement of motor and depressive symptoms of patients with Parkinson’s disease: A randomized, double-blind, placebo-controlled clinical trial

Journal of Herbal Medicine (2024)

Vahirezad Lalezari Vajiheh Aghamollaii Amir Moslehi Amir Najafi Mohammadamin Parsaei

10.1016/j.hermed.2024.100968

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Trail Making Test Could Predict Impairment in Cognitive Domains in Patients with Multiple Sclerosis: A Study of Diagnostic Accuracy

Archives of Clinical Neuropsychology (2022)

Samaneh Kabiri Melika Jameie Pargol Balali Sahand Adib Moradi Hossein Sanjari Moghaddam

Cognitive impairment (CI) and executive dysfunction (ED) are prevalent in patients with multiple sclerosis (PwMS). The Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) is the gold standard neuropsychological battery (NPB) for detecting CI. Delis-Kaplan Executive Function System (DKEFS) NPB evaluates ED. We aimed to find practical test(s) from DKEFS with acceptable diagnostic utility for early detection of impairment in cognitive and executive domains.Cognitive and executive tasks, physical disability, and depression scores of 30 PwMS were assessed (17 women, age: 38.1). Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test (PASAT), and Controlled Oral Word Association Test (COWAT) from MACFIMS and Trail Making Test (TMT), Design Fluency Test (DFT), and Verbal Fluency Test (VFT) from DKEFS were selected. The association between patients' characteristics and performance in tests, and diagnostic accuracy of DKEFS tests in detecting impairment in cognitive tasks were evaluated, using Pearson correlation and receiver operator characteristic curve analyses, respectively.A significant correlation was found between disease duration and SDMT and TMT subtests. Expanded Disability Status Scale was significantly related to SDMT, VFT-switching, and TMT subtests. Beck Depression Inventory was significantly related to DFT. TMT-switching detected abnormalities in SDMT and PASAT with 100% sensitivity, 93.3% (for SDMT), and 85.7% specificity (for PASAT). TMT-letter showed 100% sensitivity and 90% specificity in identifying abnormalities in COWAT.TMT, particularly the switching condition, is a practical paper-based test that could predict impairment in cognitive tasks. Clinicians may use TMT as a screening tool among PwMS.

Trail Making Test

Verbal fluency test

Executive dysfunction

Boston Naming Test

Neuropsychological test

10.1093/arclin/acac059

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Citations (13)