Yulin Zhao

Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)

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Paul A. Slesinger

Allen Institute for Brain Science

Danqi Lu

Sun Yat-sen University

Haoran Lin

Jiangsu Province Hospital

Ian W. Glaaser

Icahn School of Medicine at Mount Sinai

Xue Yu

Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)

Liangge He

Shenzhen University

Robert W. Peoples

Marquette University

Hong Ren

Shanghai Children's Medical Center

Yamuna Kalyani Mathiharan

Icahn School of Medicine at Mount Sinai

Jiachang Xu

Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)

Cooperative Institutions

Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)

Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)

Sun Yat-sen University

Duke Medical Center

Duke University Hospital

Shandong University

University of British Columbia

British Columbia Children's Hospital

Duke University

Shanghai Jiao Tong University

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TAP1 and TAP2 polymorphisms associated with ankylosing spondylitis in genetically homogenous Chinese Han population

Human Immunology (2009)

Ming-Liang Feng Biao Yin Tong Shen Qing Ma Lidong Liu

SNP

10.1016/j.humimm.2009.01.028

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Citations (23)

Gain-of-function KCNJ6 Mutation in a Severe Hyperkinetic Movement Disorder Phenotype

Neuroscience (2018)

Gabriella Horváth Yulin Zhao Maja Tarailo‐Graovac Cyrus Boelman Harinder Gill

10.1016/j.neuroscience.2018.05.031

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Citations (25)

Molecular characterization and functional study of the NLRP3 inflammasome genes in Tetraodon nigroviridis

Fish & Shellfish Immunology (2022)

Niuniu Deng Yulin Zhao Jiachang Xu Haofeng Ouyang Ziyi Wu

10.1016/j.fsi.2022.10.017

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Citations (6)

MEK1/2 inhibitors reverse acute vascular occlusion in mouse models of sickle cell disease

The FASEB Journal (2015)

Yulin Zhao Evan Schwartz Gregory M. Palmer Rahima Zennadi

In sickle cell disease (SCD), treatment of recurrent vasoocclusive episodes, leading to pain crises and organ damage, is still a therapeutic challenge. Vasoocclusion is caused primarily by adherence of homozygous for hemoglobin S (SS) red blood cells (SSRBCs) and leukocytes to the endothelium. We tested the therapeutic benefits of MEK1/2 inhibitors in reversing vasoocclusion in nude and humanized SCD mouse models of acute vasoocclusive episodes using intravital microscopy. Administration of 0.2, 0.3, 1, or 2 mg/kg MEK1/2 inhibitor to TNF-α-pretreated nude mice before human SSRBC infusion inhibited SSRBC adhesion in inflamed vessels, prevented the progression of vasoocclusion, and reduced SSRBC organ sequestration. By use of a more clinically relevant protocol, 0.3 or 1 mg/kg MEK1/2 inhibitor given to TNF-α-pretreated nude mice after human SSRBC infusion and onset of vasoocclusion reversed SSRBC adhesion and vasoocclusion and restored blood flow. In SCD mice, 0.025, 0.05, or 0.1 mg/kg MEK1/2 inhibitor also reversed leukocyte and erythrocyte adhesion after the inflammatory trigger of vasoocclusion and improved microcirculatory blood flow. Cell adhesion was reversed by shedding of endothelial E-selectin, P-selectin, and αvβ3 integrin, and leukocyte CD44 and β2 integrin. Thus, MEK1/2 inhibitors, by targeting the adhesive function of SSRBCs and leukocytes, could represent a valuable therapeutic intervention for acute sickle cell vasoocclusive crises.

Intravital microscopy

Acute chest syndrome

10.1096/fj.15-278481

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Citations (16)

A Scalable Deep Network for Graph Clustering via Personalized PageRank

Applied Sciences (2022)

Yulin Zhao Xunkai Li Yinlin Zhu Jin Li Shuo Wang

Recently, many models based on the combination of graph convolutional networks and deep learning have attracted extensive attention for their superior performance in graph clustering tasks. However, the existing models have the following limitations: (1) Existing models are limited by the calculation method of graph convolution, and their computational cost will increase exponentially as the graph scale grows. (2) Stacking too many convolutional layers causes the over-smoothing issue and neglects the local graph structure. (3) Expanding the range of the neighborhood and the model depth together is difficult due to the orthogonal relationship between them. Inspired by personalized pagerank and auto-encoder, we conduct the node-wise graph clustering task in the undirected simple graph as the research direction and propose a Scalable Deep Network (SDN) for graph clustering via personalized pagerank. Specifically, we utilize the combination of multi-layer perceptrons and linear propagation layer based on personalized pagerank as the backbone network (i.e., the Quasi-GNN module) and employ a DNN module for auto-encoder to learn different dimensions embeddings. After that, SDN combines the two embeddings correspondingly; then, it utilizes a dual self-supervised module to constrain the training of the embedding and clustering process. Our proposed Quasi-GNN module reduces the computational costs of traditional GNN models in a decoupled approach and solves the orthogonal relationship between the model depth and the neighborhood range. Meanwhile, it also alleviates the degraded clustering effect caused by the over-smoothing issue. We conducted experiments on five widely used graph datasets. The experimental results demonstrate that our model achieves state-of-the-art performance.

PageRank

Smoothing

Autoencoder

10.3390/app12115502

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Citations (2)

CRYO-EM Structures of the GIRK2 Channel Reveal Mechanisms for Lipid Modulation

Biophysical Journal (2020)

Ian W. Glaaser Yamuna Kalyani Mathiharan Yulin Zhao Georgios Skiniotis Paul A. Slesinger

Kir6.2

10.1016/j.bpj.2019.11.2749

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Citations (1)

Radiographic analysis of the sacral-2-alar screw trajectory

Journal of Orthopaedic Surgery and Research (2021)

Yulin Zhao Baisheng Yuan Yijun Han Binglei Zhang

To explore the feasibility of sacral-2-alar (S2-alar) screw placement by measuring the length, diameter, and angle of the screw trajectory on computed tomography (CT).This study selected 100 Han-nationality adults in northern China with a normal spine and pelvis. CT data were imported into PHILIPS software for reconstructing the 3D digital images. The optimal S2-alar screw trajectory was imitated on CT. Parameters including the length of the screw trajectory, sagittal angle, coronal angle, distance between the entry point and the spinous process, and minimum diameter of the screw trajectory were measured to evaluate the application of S2-alar screws.In total, 48 males and 52 females were included. The average length of the left screw trajectory was 47.18 ± 3.91 mm. The sagittal angle was 29.06 ± 4.00°. The coronal angle was 13.31 ± 6.95°. The distance between the entry point and the spinous process was 21.0 (3.7) mm. The minimum diameter of the screw trajectory was 17.1 (2.3) mm. The average length of the right screw trajectory was 45.46 ± 4.37 mm. The sagittal angle was 23.33 ± 4.26°. The coronal angle was 14.88 ± 6.84°. The distance between the entry point and the spinous process was 22.8 (2.9) mm. The minimum diameter of the screw trajectory was 16.9 (3.1) mm. In women, the average length of the left screw trajectory was 44.80 ± 3.66 mm. The sagittal angle was 32.14 ± 5.48°. The coronal angle was 16.04 ± 7.74°. The distance between the entry point and the spinous process was 21.8 (2.8) mm. The minimum diameter of the screw trajectory was 17.1 (5) mm. The average length of the right screw trajectory was 44.01 ± 3.72 mm. The sagittal angle was 25.12 ± 5.19. The coronal angle was 16.67 ± 8.34°. The distance between the entry point and the spinous process was 21.6 (2.7) mm. The minimum diameter of the screw trajectory was 17 (4.5) mm. As seen from the data, there were significant differences in the minimum diameter of the screw trajectory in both males and females. In females, there were also significant differences between the left and right sides in the coronal angle. Between males and females, there were statistically significant differences in the length of the screw trajectory. There were no statistically significant differences in the other parameters between males and females.The optimal screw trajectory of the S2-alar screw can be found on CT. The length and deflection angle of the screw meet the clinical requirements. This method is easy to perform and feasible for clinical application.

10.1186/s13018-021-02626-9

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Citations (1)

Structure-Based Discovery of an Alcohol-Like Activator (GiGA1) of GIRK Channels

Alcohol (2023)

Yulin Zhao Jaume Taura Ganesha Bantukallu Juan Marugán Avner Schlessinger

10.1016/j.alcohol.2023.03.055

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Citations (0)

Structural basis of GIRK2 channel modulation by cholesterol and PIP₂

bioRxiv (Cold Spring Harbor Laboratory) (2020)

Yamuna Kalyani Mathiharan Ian W. Glaaser Yulin Zhao Michael J. Robertson Georgios Skiniotis

ABSTRACT G protein-gated inwardly rectifying potassium (GIRK) channels play important roles in controlling cellular excitability in the heart and brain. While structural data begin to unravel the molecular basis for G protein and alcohol dependent activation of GIRK channels, little is known about the modulation by cholesterol. Here, we present cryo-electron microscopy (cryoEM) structures of GIRK2 in the presence and absence of the cholesterol analog cholesteryl hemisuccinate (CHS), and PIP 2 . The structures and their comparison reveal that CHS binds near PIP 2 in lipid-facing hydrophobic pockets of the transmembrane domain (TMD). CHS potentiates the effects of PIP 2 , which stabilizes the inter-domain region and promotes the engagement of the cytoplasmic domain (CTD) onto the transmembrane region. The results suggest that CHS acts as a positive allosteric modulator and identify novel therapeutic sites for modulating GIRK channels in the brain.

10.1101/2020.06.04.134544

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Citations (5)

Different sites of alcohol action in the NMDA receptor GluN2A and GluN2B subunits

Neuropharmacology (2015)

Yulin Zhao Hong Ren Donard S. Dwyer Robert W. Peoples

10.1016/j.neuropharm.2015.05.018

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Citations (24)