Yangke Tu

Tianjin First Center Hospital

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Wenyu Zhang

Jinan Central Hospital

Wenxiu Chang

Tianjin Medical University

Xichao Wang

Soochow University

Yingying Han

University of Shanghai for Science and Technology

Ying Liu

Xuzhou Medical College

Xinyuan Song

Biotechnology Research Institute

Na Sun

Chinese Academy of Medical Sciences & Peking Union Medical College

Chien‐Hsing Wu

Chang Gung University

Zhao Hu

Yibin Vocational and Technical College

Ting Ye

Huazhong University of Science and Technology

Cooperative Institutions

Tianjin Medical University

Tianjin First Center Hospital

The University of Texas Southwestern Medical Center

Kaohsiung Chang Gung Memorial Hospital

Huazhong University of Science and Technology

Nankai University

Chang Gung University

Tongji Hospital

Xuzhou Medical College

Second Affiliated Hospital of Harbin Medical University

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Treatment of membranous nephropathy with mizoribine: A control trial

Life Sciences (2016)

Xichao Wang Xinyuan Song Ying Liu Wenyu Zhang Wenwen An

Mizoribine

Membranous Nephropathy

Tolerability

Regimen

10.1016/j.lfs.2016.04.012

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Serum from hemodialysis patients induces apoptosis of HUVECs

Basic & Clinical Medicine (2012)

Yangke Tu

Objective To validate the apoptosis of HUVECs induced by hemodialysis patients serum and to explore the mechanism.Methods HUVECs are exposed to culture medium containing serum obtained from patients undergoing haemodialysis(trial group) and healthy volunteers(control group).The effect of uraemic serum on the apoptosis of endothelial cells in vascular networks are observed under light-microscope;Cell proliferation are measured by MTT;Apoptotic cells in vascular networks are evaluated by TUNEL;To investigate the expression of caspase-3 and production of ROS,cell lysates are evaluated by western blotting and spectrophotometry.Results After HUVECs are exposed to pooled serum medium for 40 h,there are apoptotic endothelial cells in vascular networks(P0.05) and the endothelial cells produce more ROS in trial group(P0.05).At 40 h,the expression level of caspase-3 in endothelial cells in trial group is 0.83±0.03,significantly higher than in control group(0.57±0.02)(P0.05).Conclusion Hemodialysis patients serum can induce apoptosis of HUVECs in vascular networks.Higher expression of caspase-3 and more production of ROS in endothelial cells may be involved in the mechanism.

MTT assay

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The Synergistic Value of Time-Averaged Serum Albumin and Globulin in Predicting the First Peritonitis in Incident Peritoneal Dialysis Patients

Blood Purification (2019)

Wenyu Zhang Xichao Wang Ying Liu Yingying Han Jinping Li

The prognostic value of serum time-averaged albumin (TA-Alb) and time-averaged globulin (TA-Glo) combination on the peritonitis in peritoneal dialysis (PD) patients is unknown.The patients who started PD treatment between July 2013 and 2018 were included. Serum Alb and globulin (Glo) were tested at baseline and monthly during follow-up. TA-Alb and TA-Glo were calculated until first peritonitis occurred or the end of the study. PD patients were divided into 4 groups based on the medians of TA-Alb and TA-Glo separately. Cox regression was conducted to identify the hazard ratios (HRs) of peritonitis among categorical groups.Three hundred and sixty-three patients were included and among them 109 patients experienced first peritonitis. Peritonitis patients had lower baseline Alb, TA-Alb, and TA-Glo levels and ultrafiltration volume. Multivariate cox regression analysis revealed that TA-Alb, TA-Glo, and baseline Alb were significantly associated with first peritonitis. The highest HR existed in Group 1 with lower Alb and lower Glo (HR 4.57, 95% CI 2.36-8.87, p < 0.001) compared with Group 4 with higher Alb and higher Glo.Lower TA-Glo is an independent risk factor for the first peritonitis in PD patients. Combined with lower TA-Alb will increase the predictive effect than separate factor alone.

10.1159/000504036

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The green tea polyphenol (−)-epigallocatechin-3-gallate ameliorates experimental immune-mediated glomerulonephritis

Kidney International (2011)

Ai Peng Ting Ye Dinesh Rakheja Yangke Tu Tao Wang

Gallate

10.1038/ki.2011.121

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The Association of Longitudinal Serum Uric Acid and All-Cause Mortality in Incident Peritoneal Dialysis Patients

Blood Purification (2018)

Wenxiu Chang Wenyu Zhang Xichao Wang Ying Liu Yingying Han

Background: Time-averaged uric acid (TA-UA) value was calculated to investigate the association of longitudinal UA and all-cause mortality in incident peritoneal dialysis (PD) patients. Methods: Three hundred PD patients were divided into 3 groups based on the serum TA-UA level (Group 1: < 6 mg/dL; Group 2: 6–8 mg/dL; Group 3: ≥8 mg/dL). Hazards ratio (HR) of all-cause mortality was calculated. Logistic regression was conducted to identify the associated clinical factors of lower and higher TA-UA level. Results: Increased HRs for death existed in Group 1 and Group 3 compared with Group 2 (HR 3.24, 95% CI 1.25–8.39, p = 0.016; HR 4.69, 95% CI 1.24–17.72, p = 0.023). Lower residual renal function, lower albumin, and higher high-density lipoprotein cholesterol were related to the lower serum TA-UA. Higher body mass index and higher C-reactive protein were associated with higher serum TA-UA in PD patients. Conclusion: Both TA-UA < 6 and ≥8 mg/dL increased the all-cause mortality in incident PD patients.

10.1159/000494987

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Citations (13)

Effects of Peritoneal Dialysis on Clinical Factors and Functional Performance

Blood Purification (2019)

Wenxiu Chang Liu Ying Ben‐Chung Cheng Wenyu Zhang Chien‐Hsing Wu

Background: We investigated the longitudinal trend of functional performance in peritoneal dialysis (PD) patients over 1 year after PD commencement and its related clinical parameters. Methods: One hundred and ninety-six PD patients were enrolled in this study. Karnofsky Performance Status Scale(KPSS) scores were used to assess functional performance. Patients were stratified into 3 groups according to the changes in KPSS from baseline to 1 year. A logistic regression analysis was performed to examine the associations of clinical parameters with KPSS changes. Results: Patients with KPSS declined showed older age and higher serum albumin concentration reduction within 1 year than those in KPSS improved and stable changes. Age was the significant risk factor for KPSS decline, while male and diabetes were significantly associated with non-declined KPSS by multivariable logistic regression analysis. Conclusion: The main determinants of KPSS trend were age, sex, and diabetes in new PD patients.

10.1159/000496081

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Citations (4)

The effects of depression and age on sleep disturbances in patients with non-dialysis stage 3–5 chronic kidney disease: a single-center study

International Urology and Nephrology (2020)

Yingying Han Xinyuan Song Ying Liu Wenyu Zhang Jinping Li

Depression

Nephrology

10.1007/s11255-020-02416-y

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Citations (14)