Congde Huo

Northwest Normal University

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i-10 index

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Xi‐Cun Wang

Northwest Normal University

Xiaodong Jia

Zhengzhou University

Yong Yuan

Northwest Normal University

Xiazhen Bao

Northwest Normal University

Zheng‐Jun Quan

Northwest Normal University

Fengjuan Chen

Lanzhou University

Haisheng Xie

South China University of Technology

Yajun Wang

Ningbo University

Yingpeng Su

Northwest Normal University

Xiaolong Xu

Shenyang Pharmaceutical University

Cooperative Institutions

Northwest Normal University

118

Chinese Academy of Sciences

Lanzhou City University

Lanzhou University

Air Force Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Ministry of Education of the People's Republic of China

Xijing Hospital

Sichuan University

Shanghai Jiao Tong University

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Friedel–Crafts alkylation of 2-naphthols with enamides and enethers induced by catalytic amount of triarylaminium salt

Tetrahedron (2014)

Congde Huo Lisheng Kang Xiaolong Xu Xiaodong Jia Xi‐Cun Wang

Friedel–Crafts reaction

Sodium salt

10.1016/j.tet.2013.12.067

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Citations (16)

Triphenylphosphine-m-sulfonate/Carbon Tetrabromide as an Efficient and Easily Recoverable Catalyst System for Friedel–Crafts Alkylation of Indoles with Carbonyl Compounds or Acetals

ACS Sustainable Chemistry & Engineering (2013)

Congde Huo Chougu Sun Cheng Wang Xiaodong Jia Wenju Chang

A solid complex, conveniently prepared from commercially available sodium triphenylphosphine-m-sulfonate (TPPMS) and carbon tetrabromide, can be used as an easily recoverable and reusable catalyst system for Friedel–Crafts alkylation of indoles with carbonyl compounds or acetals to produce bis(indolyl)alkane products (BIAs).

Friedel–Crafts reaction

Carbon fibers

Alkane

10.1021/sc400033t

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Citations (58)

ChemInform Abstract: A Novel Liquid‐Phase Strategy for Organic Synthesis Using Organic Ions as Soluble Supports

ChemInform (2010)

Congde Huo Tak Hang Chan

Abstract Review: 136 refs.

Organic Synthesis

Liquid phase

10.1002/chin.201047239

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Citations (0)

Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells

International Journal of Molecular Medicine (2010)

Andrew Davenport Michael Frezza Min Shen Yubin Ge Congde Huo

Chemotherapy remains the staple of treatment for many types of leukemia. Despite the positive impact on extending overall survival in patients with hematological malignancies, new treatment strategies are needed to reduce the nonspecific toxicity and improve the efficacy of treatment. Celastrol, derived from the ‘Thunder God Vine’ and Pro-EGCG, a pre-drug version of green tea polyphenol EGCG have shown potent biological activity in vitro and in vivo. Whether these natural products augment the efficacy of conventional chemotherapy in the treatment of leukemia cells has yet to be demonstrated. Here we demonstrate that these natural products could sensitize the effect of chemotherapy in both K-562 and Jurkat T human leukemia cells. Accordingly, this potent biological activity was associated with increased levels of leukemia cell killing, caspase 3 activation, and poly(ADP-ribose) polymerase cleavage. Furthermore, the higher levels of apoptotic indices were associated with decreased levels of Bcr-Abl oncoprotein in K-562 cells. Taken together, our findings present a compelling rationale for the development of combination strategies using natural products in the treatment of hematological malignancies.

Jurkat cells

Celastrol

10.3892/ijmm_00000366

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Citations (36)

A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid

Sensors and Actuators B Chemical (2021)

Xiazhen Bao Xuehui Cao Yong Yuan Bo Zhou Congde Huo

Hypochlorous acid

10.1016/j.snb.2021.130210

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Citations (47)

Visible-light-mediated iodine-catalyzed α-hydroxylation of α-methylene ketones under aerobic conditions

Organic Chemistry Frontiers (2018)

Jingya Yang Dong‐Tai Xie Hongyan Zhou Shuwen Chen Congde Huo

A visible-light-mediated α-hydroxylation of α-methylene ketones using atmospheric oxygen as a green oxidant has been developed with novel substrate selectivity.

Hydroxylation

Methylene

Visible spectrum

Methylene blue

10.1039/c8qo00056e

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Citations (42)

Copper-catalyzed oxidative phosphonation of 3,4-dihydro-1,4-benzoxazin-2-ones

Organic Chemistry Frontiers (2018)

Jie Wang Jun Li Yuanyuan Wei Jingya Yang Congde Huo

A straight-forward and atom-economical Cu(ii)/PBQ-catalyzed oxidative Pudovik reaction of 3,4-dihydro-1,4-benzoxazin-2-ones has been developed to construct new C_sp3–P bonds.

10.1039/c8qo01049h

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Citations (42)

Ultrafast Detection of Sulfur Dioxide Derivatives by a Distinctive “Dual-Positive-Ion” Platform that Features a Doubly Activated but Irreversible Michael Addition Site

Journal of Agricultural and Food Chemistry (2021)

Xiazhen Bao Xuehui Cao Yong Yuan Bo Zhou Congde Huo

Sulfur dioxide (SO2) is a gaseous signaling molecule and widely used as a preservative for foods, but its excessive intake is closely related to a series of diseases. Therefore, the development of a potent fluorescence probe for the detection of SO2 in foods and biological systems is of great significance. Herein, we report for the first time a "dual-positive-ion" platform-based fluorescence probe CMQ, designed by a doubly activated but irreversible strategy, which results in its ultrafast response to SO2 within 5 s in pure aqueous solution together with a low detection limit as 15.6 nM. In addition, the probe was successfully applied for imaging of SO2 in mitochondria of living cells and zebrafish and prepared as a reagent kit for convenient and instantaneous quantification of HSO3– in real food samples.

10.1021/acs.jafc.1c00797

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Citations (16)

ChemInform Abstract: A Clean and Efficient Conversion of Aldehydes into the Corresponding Nitriles Using Ionic Supported Triphenylphosphine and CBr₄.

ChemInform (2013)

Congde Huo Chen Wang Dongcheng Hu Xiaodong Jia

10.1002/chin.201348097

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Citations (0)

Base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS₂ for the synthesis of quinoline-2-thiones

Chemical Communications (2017)

Tong-Lin Wang Xiaojun Liu Congde Huo Xi‐Cun Wang Zheng‐Jun Quan

Here we show that the base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 is a powerful methodology to synthesize quinoline-2-thiones. This thio-lactamization uses inexpensive and versatile 2-(1-arylvinyl)anilines, which are easily available from the reaction of amines and alkynes. Compared to the known strategy in the literature, this method features the advantages like a short synthesis step and easily available starting materials.

Quinoline

Thio-

Base (topology)

10.1039/c7cc07633a

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Citations (32)