Magdalena Martínez‐Garcia

University of California, Santa Barbara

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Susanna Carmona

Centro de Investigación Biomédica en Red de Salud Mental

ÓV

Óscar Vilarroya

Universitat Autònoma de Barcelona

Manuel Desco

Universidad Carlos III de Madrid

María Paternina-Die

Hospital General Universitario Gregorio Marañón

Clara Pretus

Universitat Autònoma de Barcelona

Luis Marcos‐Vidal

Hospital Del Mar

Anna Soler

Hospital Del Mar

Darby E. Saxbe

University of Southern California

Daniel Martín de Blas

Hospital General Universitario Gregorio Marañón

Camila Servin-Barthet

Universitat Autònoma de Barcelona

Cooperative Institutions

Hospital General Universitario Gregorio Marañón

Universitat Autònoma de Barcelona

Centro de Investigación Biomédica en Red de Salud Mental

Hospital Del Mar

Instituto de Salud Carlos III

University of Southern California

Municipal Institute for Medical Research

Southern California University for Professional Studies

Centro de Investigación Biomédica en Red

Hospital del Mar Research Institute

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Sensory-to-Cognitive Systems Integration Is Associated With Clinical Severity in Autism Spectrum Disorder

Journal of the American Academy of Child & Adolescent Psychiatry (2019)

Kenia Martínez Magdalena Martínez‐Garcia Luis Marcos‐Vidal Joost Janssen F. Xavier Castellanos

Sensory Processing

10.1016/j.jaac.2019.05.033

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Citations (53)

Cover Image

Human Brain Mapping (2019)

Susanna Carmona Magdalena Martínez‐Garcia María Paternina‐Die Erika Barba‐Müller Lara M. Wierenga

COVER ILLUSTRATION This image aims to reflect the parallelism that exists between the morphometric brain changes that occur during pregnancy and those that take place during adolescence. The image has no copyright and the neurons were inspired in one of the Ramon y Cajal drawings.

10.1002/hbm.24262

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Citations (0)

Recent Neuroscience Advances in Human Parenting

Advances in neurobiology (2022)

Magdalena Martínez‐Garcia Sofia I. Cárdenas Jodi L. Pawluski Susanna Carmona Darby E. Saxbe

Biological neural network

Human brain

10.1007/978-3-030-97762-7_8

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Citations (3)

Changes in left hippocampal volume in first‐time fathers: Associations with oxytocin, testosterone, and adaptation to parenthood

Journal of Neuroendocrinology (2023)

Darby E. Saxbe Magdalena Martínez‐Garcia Sofia I. Cárdenas Yael Waizman Susanna Carmona

Abstract The parenting brain may undergo remodeling that supports the adjustment to new parenthood. Prior work on human mothers has found gray matter volume decreases from preconception to early postpartum in multiple structures, including the left hippocampus, which was the only structure to show gray matter volume recovery at 2 years postpartum. This is consistent with evidence from animal models that the hippocampus is unusually plastic across reproductive transitions. However, no studies have focused specifically on hippocampal volume changes in human fathers. Among 38 men who were scanned by magnetic resonance imaging (MRI) before and after having their first child, individual differences in left hippocampal volume changes were associated with men's prenatal oxytocin, postpartum testosterone, and postpartum adaptation to parenthood. Across the whole sample, hippocampal volumes did not change significantly from prenatal to postpartum. However, men who showed larger increases in left hippocampal volume from prenatal to postpartum reported stronger parent–child bonding and affectionate attachment and lower parenting stress. Fathers with higher levels of prenatal oxytocin showed larger left hippocampal volume increases across the transition to parenthood. In turn, greater increases in left hippocampal volume predicted lower postpartum testosterone after adjusting for prenatal testosterone. These findings did not extend to the right hippocampus. In conclusion, remodeling of the left hippocampus across the transition to new fatherhood may reflect adaptation to parenthood in human males.

10.1111/jne.13270

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Pregnancy and adolescence entail similar neuroanatomical adaptations: A comparative analysis of cerebral morphometric changes

Human Brain Mapping (2019)

Susanna Carmona Magdalena Martínez‐Garcia María Paternina‐Die Erika Barba‐Müller Lara M. Wierenga

Abstract Mapping the impact of pregnancy on the human brain is essential for understanding the neurobiology of maternal caregiving. Recently, we found that pregnancy leads to a long‐lasting reduction in cerebral gray matter volume. However, the morphometric features behind the volumetric reductions remain unexplored. Furthermore, the similarity between these reductions and those occurring during adolescence, another hormonally similar transitional period of life, still needs to be investigated. Here, we used surface‐based methods to analyze the longitudinal magnetic resonance imaging data of a group of 25 first‐time mothers (before and after pregnancy) and compare them to those of a group of 25 female adolescents (during 2 years of pubertal development). For both first‐time mothers and adolescent girls, a monthly rate of volumetric reductions of 0.09 mm 3 was observed. In both cases, these reductions were accompanied by decreases in cortical thickness, surface area, local gyrification index, sulcal depth, and sulcal length, as well as increases in sulcal width. In fact, the changes associated with pregnancy did not differ from those that characterize the transition during adolescence in any of these measures. Our findings are consistent with the notion that the brain morphometric changes associated with pregnancy and adolescence reflect similar hormonally primed biological processes.

Gyrification

Brain Development

Human brain

Brain morphometry

10.1002/hbm.24513

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Citations (80)

Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults

Journal of Attention Disorders (2022)

Luis Marcos‐Vidal Magdalena Martínez‐Garcia Daniel Martín de Blas Francisco J. Navas‐Sánchez Clara Pretus

Objective: Neuroimaging studies in children with ADHD indicate that their brain exhibits an atypical functional connectivity pattern characterized by increased local connectivity and decreased distant connectivity. We aim to evaluate if the local and distant distribution of functional connectivity is also altered in adult samples with ADHD who have never received medication before. Methods: We compared local and distant functional connectivity between 31 medication-naïve adults with ADHD and 31 healthy controls and tested whether this pattern was associated with symptoms severity scores. Results: ADHD sample showed increased local connectivity in the dACC and the SFG and decreased local connectivity in the PCC. Conclusion: Results parallel those obtained in children samples suggesting a deficient integration within the DMN and segregation between DMN, FPN, and VAN. These results are consistent with the three main frameworks that explain ADHD: the neurodevelopmental delay hypothesis, the DMN interference hypothesis, and multi-network models.

10.1177/10870547221101646

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Presence of fetal microchimerisms in the heart and effect on cardiac repair

Frontiers in Cell and Developmental Biology (2024)

Vicente Llorente Marina López‐Olañeta Elena Blázquez‐López Elena Vázquez-Ogando Magdalena Martínez‐García

Multiple complex biological processes take place during pregnancy, including the migration of fetal cells to maternal circulation and their subsequent engraftment in maternal tissues, where they form microchimerisms. Fetal microchimerisms have been identified in several tissues; nevertheless, their functional role remains largely unknown. Different reports suggest these cells contribute to tissue repair and modulate the immune response, but they have also been associated with pre-eclampsia and tumor formation. In the maternal heart, cells of fetal origin can contribute to different cell lineages after myocardial infarction. However, the functional role of these cells and their effect on cardiac function and repair are unknown. In this work, we found that microchimerisms of fetal origin are present in the maternal circulation and graft in the heart. To determine their functional role, WT female mice were crossed with male mice expressing the diphtheria toxin (DT) receptor. Mothers were treated with DT to eliminate microchimerisms and the response to myocardial infarction was investigated. We found that removal of microchimerisms improved cardiac contraction in postpartum and post-infarction model females compared to untreated mice, where DT administration had no significant effects. These results suggest that microchimerisms play a detrimental role in the mother following myocardial infarction.

Microchimerism

Diphtheria Toxin

10.3389/fcell.2024.1390533

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Women’s neuroplasticity during gestation, childbirth and postpartum

Nature Neuroscience (2024)

María Paternina-Die Magdalena Martínez‐Garcia Daniel Martín de Blas Inés Noguero-Soler Camila Servin-Barthet

Pregnancy is a unique neuroplastic period in adult life. This longitudinal study tracked brain cortical changes during the peripartum period and explored how the type of childbirth affects these changes. We collected neuroanatomic, obstetric and neuropsychological data from 110 first-time mothers during late pregnancy and early postpartum, as well as from 34 nulliparous women evaluated at similar time points. During late pregnancy, mothers showed lower cortical volume than controls across all functional networks. These cortical differences attenuated in the early postpartum session. Default mode and frontoparietal networks showed below-expected volume increases during peripartum, suggesting that their reductions may persist longer. Results also pointed to different cortical trajectories in mothers who delivered by scheduled C-section. The main findings were replicated in an independent sample of 29 mothers and 24 nulliparous women. These data suggest a dynamic trajectory of cortical decreases during pregnancy that attenuates in the postpartum period, at a different rate depending on the brain network and childbirth type.

10.1038/s41593-023-01513-2

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Fathers matter from the start: The role of expectant fathers in child development

Child Development Perspectives (2021)

Sofia I. Cárdenas Alyssa R. Morris Narcis Marshall Elizabeth C. Aviv Magdalena Martínez‐García

Abstract Extensive research has established that fathers’ engagement in parenting benefits children, but few studies have described how fathers contribute to child development even before birth. In this article, we consider both direct and indirect pathways through which expectant fathers shape child development during the prenatal period. Regarding direct pathways, we review work on expectant fathers’ contributions to child development through genetic and epigenetic processes, as well as neuroendocrine mechanisms. Regarding indirect pathways, we outline ways in which expectant fathers indirectly influence child development through the couple relationship. In so doing, we seek to provide a foundation from which to formulate future lines of inquiry on the role of expectant fathers in child development. This research can inform clinical interventions and policies geared toward improving the early caregiving environment and child development.

Child Development

Childhood development

10.1111/cdep.12436

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Citations (25)

Feto-maternal microchimerism: Memories from pregnancy

iScience (2021)

Blanca Cómitre-Mariano Magdalena Martínez‐García Bárbara García-Gálvez María Paternina-Die Manuel Desco

There is a bidirectional transplacental cell trafficking between mother and fetus during pregnancy in placental mammals. The presence and persistence of fetal cells in maternal tissues are known as fetal microchimerism (FMc). FMc has high multilineage potential with a great ability to differentiate and functionally integrate into maternal tissue. FMc has been found in various maternal tissues in animal models and humans. Its permanence in the maternal body up to decades after delivery suggests it might play an essential role in maternal pathophysiology. Studying the presence, localization, and characteristics of FMc in maternal tissues is key to understanding its impact on the woman's body. Here we comprehensively review the existence of FMc in different species and organs and tissues, aiming to better characterize their possible role in human health and disease. We also highlight several methodological considerations that would optimize the detection, quantification, and functional determination of FMc.

Microchimerism

Transplacental

10.1016/j.isci.2021.103664

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Citations (28)