Mahmoud Abdo Ashour

Zagazig University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Saada Elsayed Salama

Al-Azhar University

Maamar Ahmed Hasan

Fayroz Othman Selim

Zagazig University

Asmaa Osh

Zagazig University

Monkez Yousif

Zagazig University

Samir A. Afifi

Zagazig University

Cooperative Institutions

Zagazig University

Al-Azhar University

British Society for Antimicrobial Chemotherapy

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Colonoscopic Findings among Patients with Lower Gastrointestinal Tract Bleeding Admitted to Intensive Care Unit

The Egyptian Journal of Hospital Medicine (2022)

Monkez Yousif Mahmoud Abdo Ashour Fayroz Othman Selim Maamar Ahmed Hasan

Background: Acute lower gastrointestinal bleeding (LGIB) is an alarming indication and common disease with annual admission of 0.15% with mortality rate of 5-10%.LGIB is caused by neoplastic and non-neoplastic lesions.Objective: The aim of the present study was to evaluate frequency of patients admitted to Medical Intensive Care Unit (MICU) of Zagazig University Hospitals (ZUH) with lower gastrointestinal tract bleeding.Patients and methods: A prospective cohort study included 266 subjects and carried out at in Intensive Care Unit, Faculty of Medicine, Zagazig University.All studied population were subjected to full history taking, general examination, laboratory investigation and colonoscopy examination.Results: Age of the studied cases ranged from 18 to 75 years with mean 46.24 years and more than half of them were males (53.3%).The most frequent presentation among the studied cases was hematochezia (95%).Colonoscopic findings among the study population (n=257) showed that 5.8% had diverticular disease, 32.3% had inflammatory alteration and 2.3% had solitary ulcer. Conclusion: AcuteLGITB is a common and challenging problem in MICU of ZUH with ulcerative colitis, bleeding piles, and malignancy as the major underlying causes.Colonoscopy represents the most important diagnostic modality.

Gastrointestinal bleeding

10.21608/ejhm.2022.226162

Cite

Citations (0)

Serum Glypican-3 versus Alpha-fetoprotein in Patients with Hepatocellular Carcinoma on Top of HCV Related Liver Cirrhosis

Zagazig University Medical Journal (2024)

Mahmoud Abdo Ashour Asmaa Osh Saada Elsayed Salama Samir A. Afifi

Background: Globally, hepatocellular carcinoma (HCC) is ranked as the fourth most frequent cause of death from cancer. The creation of more precise and sensitive blood markers, like Glypican-3 (GPC-3), for the early identification of HCC may improve patient survival. So we aimed to compare the clinical significance of serum GPC-3 levels with AFP in the diagnosis of HCC on top of HCV-related liver cirrhosis. Methods: A case-control study was performed in Hepatology and Gastroenterology unit of Internal Medicine Department, Zagazig University Hospitals. Ninety subjects were divided into: Group I: proved HCC patients. Group II: liver cirrhotic patients. Group III: Normal. All participants underwent GPC-3 assessment. Results: Alpha fetoprotein (AFP) was superior on serum Glypican-3 in diagnosis of liver cirrhosis, whereas the best cutoff was (≥19.5 Vs. ≥2.25), AUC (0.945 vs. 0.859), sensitivity (93.3% vs. 83.3%), specificity (76.7% vs. 70 %), PPV (80% vs. 73.5 %), NPV (92% vs. 80.8 %), and overall accuracy (85% vs. 76.7 %) respectively. In diagnosis of HCC, Glypican-3 was superior on AFP, whereas the best cutoff of AFP vs. serum Glypican-3 was (≥32.5 Vs. ≥3.65), AUC (0.858 vs. 0.873), sensitivity (80% vs. 90%), specificity (75% vs. 76.7 %), PPV (61.5% vs. 65.9 %), NPV (88.2% vs. 93.9 %), and overall accuracy (76.7% vs. 81.1 %) respectively. Conclusion: Serum AFP alone has a low diagnostic power in diagnosing HCC. On other hand, serum GLP-3 has great sensitivity and specificity in early detection of HCC.

Glypican 3

Alpha-fetoprotein

Alpha (finance)

10.21608/zumj.2024.321552.3583

Cite

Citations (0)