Fathy El‐Taweel

Damietta University

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Synthesis of some new quinoline derivatives: new routes to synthesize polysubstituted 2(1H)-quinolone derivatives.

PubMed (2001)

Fathy El‐Taweel Diaa A. Ibrahim M. A. Hanna

Reaction of 4-hydroxyquinolines 1a,b or 1c,d with the ylidenenitriles 2b-g and 2h,c yielded pyranoquinolines 6 and 9, respectively. 4-Anilinoquinoline 10 reacted with 2a,e to give pyridoquinolines 12. Treating of 1a or 14 with SO2Cl2 gave 3-dichloroacetyl derivative 15. Compound 15 reacted with KCN/H2O and NaN3 to give furoquinoline 16 and the tetrazole 18, respectively. Reaction of 1a, b, f with a mixture of phenyl isothiocyanate and glycine gave pyranoquinoline 22. This compound reacted with chloroacetic acid to yield thiazolidinones 23. Pyranoquinolines 27 were synthesized either from the reaction of 1c,d with enamine 24 or reaction of 1e,f with hippuric acid. Condensation of 1c,d with the enamine 25 gave azlactone 28. The latter compound reacted with 4-aminoantipyrine and 2-aminopyridine to give the imidazole derivatives 30.

Enamine

Quinoline

Imidazole

Chloroacetic acid

Derivative (finance)

Hydrazone

Source

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Citations (3)

ChemInform Abstract: Synthetic Routes to Selected Heterocycles Containing Antipyrine Moiety

ChemInform (2016)

Fathy El‐Taweel Tarek Abou Elmaaty

Abstract Review: 56 refs.

Moiety

10.1002/chin.201625247

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Citations (0)

Structural, Optical, Electrical and Photoelectrical Properties of 2-Amino-4-(5-bromothiophen-2-yl)-5,6-dihydro-6-methyl-5-oxo-4H-pyrano[3,2-c] quinoline-3-carbonitrile Films

Journal of Electronic Materials (2017)

A. M. Mansour Fathy El‐Taweel R. A. N. Abu El-Enein E.M. El-Menyawy

Quinoline

Thermal Stability

10.1007/s11664-017-5739-7

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Citations (34)

Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells

Biomedicine & Pharmacotherapy (2018)

Mohammed A. El‐Magd Sara F. Khalifa Faisal A. Alzahrani Ahmed Badawy Eman S. El‐Shetry

Neurotoxicity

Bulb

BETA (programming language)

Amyloid (mycology)

10.1016/j.biopha.2018.06.014

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Citations (27)

New One Pot-synthesis of Functionally Substituted Pyridines from Enaminoketones

Journal of Heterocyclic Chemistry (2014)

Fathy El‐Taweel Tarek Abou Elmaaty

Several new pyridine derivatives were prepared via reaction of enaminoketones 1a, 1b, 1c, 1d with active hydrogen reagents. Reaction of the enaminoketones 1a, 1b, 1c with 4-acetyl-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one 2a yielded the pyridines 3a, 3b, 3c. Condensation of the enaminonitrile 1d with compounds 2b, 2c, 2d and compound 8 gave the pyridine derivatives 6a, 6b, 6c and 10 respectively. Also, (3-(dimethylamino)acryloyl)-2H-chromen-2-one 1a reacted with active methylenes in diethyl 3-oxopentanedioate 12 and 4-methyl-6-oxo-2-thioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile 15 to afford the pyridine derivatives 14 and 16 respectively.

Condensation reaction

10.1002/jhet.2291

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Citations (2)

ChemInform Abstract: Activated Nitriles in Organic Synthesis: Synthesis of Pyranoquinolinone, 6H‐2‐Benzopyrano(4,3‐c)quinolinone and Thieno(2,3‐b) pyridine.

ChemInform (1996)

Salah Zaki Ahmed Sowellim Fathy El‐Taweel A. G. A. ELAGAMEY

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.199639173

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Citations (1)

New and Facile Synthesis of Substituted Pyrrole, Pyridine, Pyrazolo[4,3-b] Pyridine, Pyrano[3,2-c] Quinoline, Napthopyran, Naphthodipyran and Coumarin Derivatives

International Journal of Organic Chemistry (2013)

Fathy El‐Taweel A. A. Elagamey

Several new pyrazolo[4,3-b] pyridines 7a, b were prepared by reacting arylidenemalononitriles 1a, c or 1i, j with 4-nitrosoantipyrine 4. Reacting 1a, b, d with 4-azidomethylcarbonylantipyrine 8 give 2-aminopyrrole 14. Pyrano[3,2-c] quinolines 20a, b and 23 were obtained by reacting 4-hydroxyquinoline 15 with 1g, h, 2b respectively. Reaction of 1 with naphthalenediols 24, 27 and 29 yield naphthodipyrans 26a, b, 28a, b and 30a,<

Quinoline

Pyrrole

10.4236/ijoc.2013.31007

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Citations (6)

ChemInform Abstract: New One Pot‐Synthesis of Functionally Substituted Pyridines from Enaminoketones.

ChemInform (2016)

Fathy El‐Taweel Tarek Abou Elmaaty

Abstract Various pyridine derivatives are obtained via the reaction of enaminoketones with active hydrogen compounds.

10.1002/chin.201611175

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Citations (0)

Therapeutic potential of bitter taste receptor agonists on amyloid β-induced rat model of Alzheimer’s disease

Egyptian Journal of Basic and Applied Sciences (2023)

Sara F. Khalifa Fathy El‐Taweel Mohamed Salama Mohammed A. El‐Magd

This study was conducted to investigate the effect of bitter taste receptor (T2R) agonists (caffeine and extracts of myrrh and Boswellia serrata) on amyloid β (Aβ)-induced Alzheimer’s disease (AD) in rats. Rats intracerebroventricularly (ICV) injected with a single dose of Aβ (3 μg/μL/rat) had significantly: 1) lower brain weight, 2) higher short-term memory impairment, 3) lower serum dopamine level, 4) higher AChE activity, 5) higher brain lipid peroxide malonaldehyde, 6) lower brain antioxidant activities of catalase, superoxide dismutase and glutathione peroxidase, 7) higher brain phosphor tau protein level, 8) higher brain levels of apoptotic markers (Bax and caspase 3), 9) lower brain level of antiapoptotic marker Bcl2, 10) downregulated brain expression of the bitter receptor (T2R4) gene, 11) upregulated brain expression of tumor necrosis factor α (TNFα) and nuclear factor κB (NF-κB) genes and 12) marked neuronal degeneration associated with severe vacuolation of neutrophils. All deteriorated effects of Aβ were restored following treatment with caffeine (20 mg/kg), myrrh aqueous extract (10 mg/kg) and Boswellia serrata aqueous extract (400 mg/kg) with best effect for myrrh aqueous extract. These data conclude that bitter taste receptor agonists (caffeine and extracts of myrrh and Boswellia serrata) had therapeutic potential on amyloid β-induced rat model of Alzheimer’s disease.

10.1080/2314808x.2023.2252635

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Citations (0)

Synthesis of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-c]-as-triazine derivatives

Collection of Czechoslovak Chemical Communications (1986)

A. G. A. ELAGAMEY Fathy El‐Taweel Fathy A. Amer

Several new pyrazolo[1,5- a ]pyrimidine and pyrazolo[1,5- c ]- as -triazine derivatives were synthesized via the reaction of 3-antipyrinyl-5-aminopyrazole or its diazonium salt with enaminonitriles, enaminoesters and active methylene reagents. The action of hydrazine hydrate on the obtained polyfunctional products was also studied.

Hydrazine (antidepressant)

Triazine

Methylene

1,3,5-Triazine

10.1135/cccc19862193

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Citations (8)